Reproductive cycle of the Belding ground squirrel ( Spermophilus beldingi beldingi ): seasonal and age differences

The reproductive cycle in Belding ground squirrels was studied in the Sierra Nevada Mountains at two locations, one at 2,100 m elevation, the other at 3,000 m. Adults emerged from hibernation completely prepared physiologically for reproduction. Males tended to emerge slightly ahead of females and yearlings tended to emerge later than adults. Yearling females were fertile but produced smaller litters than adults, 4.48 vs. 6.31. Yearling males were infertile. They exhibited a slight seasonal cycle in testicular growth but did not reach sexual maturity. Testicular growth and spermatogenesis were incipient in many adults and in yearlings prior to hibernation.       

Diurnal change in stature: effects of sleep deprivation in young men and middle-aged men

Summary Sleep deprivation was associated with decreased stature and it blunted the normal 24-h rhythm in young and in middle-aged men. Loss in stature was regained during the first recovery night of sleep. The 24-h rhythm in height is not an endogenous circadian rhythm but depends upon the periods of recumbency over the sleep/wake cycle.Acknowledgments. The first author was a Medical Research Council scholar; the second was supported by the Scottish Hospital Endowments Research Trust.     

Interaction of lipid transfer protein with plasma lipoproteins and cell membranes

Summary The hydrophobic lipid components of lipoproteins, cholesteryl ester and triglyceride, are transferred between all lipoproteins by a specific plasma glycoprotein, termed lipid transfer protein (LTP). LTP facilitates lipid transfer by an exchange process in which cholesteryl ester and triglyceride compete for transfer. Thus, LTP promotes remodeling of the lipoprotein structure, and plays an important role in the intravascular metabolism of these particles and in the lipoprotein-dependent pathways of cholesterol clearance from cells. The properties of LTP, its mechanisms of action, its roles in lipoprotein metabolism, and its modes of regulation are reviewed along with recent data that suggest a possible role for this protein in directly modifying cellular lipid composition.     

Synthese von 22,26-Imino-cholestan-Derivaten

Summary 3, 16-diacetoxy-5-pregnane-20-one and the analogue pregn-5-ene derivative have been converted into (22R, 25R)-22, 26-imino-5-cholestane-3, 16-diol. The configuration at C-22 and C-25 was determined by transformation into the known (22R, 25R)-5-solanidane-3-one. Application of the Ruschig method led to (25R)-22,26-imino-5-cholest-22(N)-ene-3, 16-diol.

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Solanum-Alkaloide. XVI. Mitteilung. — XV. Mitteilung:K. Schreiber undH. Ripperger, Tetrahedron Letters Nr.27, 9 (1960).