Genotoxic effects of dithane M-45 on the bone marrow cells of mice in vivo

Genotoxic effects of dithane M-45 were studied on the bone marrow cells of male albino mice (Lacca strain) in vivo. Different doses (30 mg, 40 mg and 300 mg/kg b.wt) of dithane M-45 were injected intraperitoneally and their effects were investigated after time intervals of 1, 2, 5 and 10 days. The chromosomal aberrations observed in the bone marrow cells of male mice after treatment with dithane M-45 were fragments, rings, dicentric chromosomes, terminal chromatid deletions, chromatid gaps and breaks. In addition to these chromosomal aberrations, physiological effects such as uneven stretching of chromatin material, end-to-end chromosomal associations, exchange configurations, clumping, stickiness and centromeric associations were also observed.     

Preliminary data on the chromosome cycle ofLycœides idas L.

Riassunto Nella specieLycides idas L. si osservano variazioni numeriche dei cromosomi anche nelle spermatogonie di uno stesso individuo. Questo fatto è posto in relazione con la presenza nelle femmine dei caratteri secondari dei due sessi, come risultato dell'unione tra gameti con assetti sbilanciati.