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951.
Molecular structure of r(GCG)d(TATACGC): a DNA--RNA hybrid helix joined to double helical DNA 总被引:20,自引:0,他引:20
A H Wang S Fujii J H van Boom G A van der Marel S A van Boeckel A Rich 《Nature》1982,299(5884):601-604
The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA--RNA hybrid segments surrounding a central region of double helical DNA; its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2' hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities. 相似文献
952.
J. B. Gibson A. V. Wilks G. K. Chambers 《Cellular and molecular life sciences : CMLS》1982,38(6):653-654
Summary A 3rd allele at theAdh locus,Adh
FCh.D., has been found at polymorphic frequencies in natural populations ofD. melanogaster. The ADH-FChD enzyme has properties distinct from those of the 2 more common forms of ADH. TheAdh polymorphism should now be analyzed as a triallelic system. 相似文献
953.
954.
Summary Desheathed rabbit vagus nerve has been found to form cyclic AMP when incubated with adenosine. This accumulation of cyclic AMP is inhibited by theophylline but not by antiadrenergic agents, anticholinergic agents or local anaesthetics. Depolarizing media are not able to promote cyclic AMP accumulation in this preparation.Acknowledgment. We gratefully acknowledge Mr.G. Jones for valuable discussion, MrsM. Moosmayer and Mr.S. Ferrara for expert technical assistance and Swiss National Science Foundation for grant support (Nr. 3.478.0.75). 相似文献
955.
956.
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958.
G Barchewitz F Binon A Cier H Tuchmann-Duplessis 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1980,291(4):409-411
When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation. 相似文献
959.
A relationship between the amount of available estradiol receptors in uteri of inbred mice and their H-2 genotype is suggested by study in congenic animals. 相似文献
960.
Summary 4000 rads of mixed gamma neutron radiation administered to rhesus monkeys released a significant amount of histamine into their circulation. When the monkeys were treated with a mast-cell histamine depleter (compound 48/80) for 4 days and then irradiated, no increase in circulating histamine was seen. When 48/80 was given 20 min after irradiation, only a slight increase in histamine was seen, indicating that 4000 rads had released most of the mast-cell histamine. 相似文献