美国中产阶级的“美国梦”研究——以《兔子,快跑》为例

"美国梦"的概念的出现,反映了美国人积极向上的精神,即人只要努力奋斗就能过上体面人的生活。围绕这种共识,约翰·厄普代克出版的《兔子,快跑》一书,生动地刻画了在美国梦理念下哈利·阿斯特罗姆的人生历程,折射了美国中产阶级面临的困惑与迷茫,并对美国梦进行了深刻的反思。     

浅谈变电站自动化系统调试

文章从变电站现场调试工作前的准备到设备投运的整个工作程序和调试方法及注意事项进行了详细介绍,并说明了细节问题应注意的事项。     

Incorporating textual and management factors into financial distress prediction: A comparative study of machine learning methods

Financial distress prediction (FDP) has been widely considered as a promising approach to reducing financial losses. While financial information comprises the traditional factors involved in FDP, nonfinancial factors have also been examined in recent studies. In light of this, the purpose of this study is to explore the integrated factors and multiple models that can improve the predictive performance of FDP models. This study proposes an FDP framework to reveal the financial distress features of listed Chinese companies, incorporating financial, management, and textual factors, and evaluating the prediction performance of multiple models in different time spans. To develop this framework, this study employs the wrapper-based feature selection method to extract valuable features, and then constructs multiple single classifiers, ensemble classifiers, and deep learning models in order to predict financial distress. The experiment results indicate that management and textual factors can supplement traditional financial factors in FDP, especially textual ones. This study also discovers that integrated factors collected 4 years prior to the predicted benchmark year enable a more accurate prediction, and the ensemble classifiers and deep learning models developed can achieve satisfactory FDP performance. This study makes a novel contribution as it expands the predictive factors of financial distress and provides new findings that can have important implications for providing early warning signals of financial risk.     

An eicosanoid-centric view of atherothrombotic risk factors

Cardiovascular disease is the foremost cause of morbidity and mortality in the Western world. Atherosclerosis followed by thrombosis (atherothrombosis) is the pathological process underlying most myocardial, cerebral, and peripheral vascular events. Atherothrombosis is a complex and heterogeneous inflammatory process that involves interactions between many cell types (including vascular smooth muscle cells, endothelial cells, macrophages, and platelets) and processes (including migration, proliferation, and activation). Despite a wealth of knowledge from many recent studies using knockout mouse and human genetic studies (GWAS and candidate approach) identifying genes and proteins directly involved in these processes, traditional cardiovascular risk factors (hyperlipidemia, hypertension, smoking, diabetes mellitus, sex, and age) remain the most useful predictor of disease. Eicosanoids (20 carbon polyunsaturated fatty acid derivatives of arachidonic acid and other essential fatty acids) are emerging as important regulators of cardiovascular disease processes. Drugs indirectly modulating these signals, including COX-1/COX-2 inhibitors, have proven to play major roles in the atherothrombotic process. However, the complexity of their roles and regulation by opposing eicosanoid signaling, have contributed to the lack of therapies directed at the eicosanoid receptors themselves. This is likely to change, as our understanding of the structure, signaling, and function of the eicosanoid receptors improves. Indeed, a major advance is emerging from the characterization of dysfunctional naturally occurring mutations of the eicosanoid receptors. In light of the proven and continuing importance of risk factors, we have elected to focus on the relationship between eicosanoids and cardiovascular risk factors.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

强夯碎石桩的发展及成桩机理分析

强夯置换法是８０年代才开始应用的软土地基处理方法,在我国已成功应用于多个工程,介绍强夯置换法的发展概况,用波动理论生阐述强夯置换法在成桩中桩土界面的变化,说明了夯击能量从第一击接近球状传播到柱状桩体后的接近一维传播变化过程;探讨了夯锤势能转换成使桩体向下延伸的动能、桩体压密的势能、通过桩体侧面和底面的向桩个传播的动能比例、分析结果表明：强夯法将粗颗粒料夯击到土形成柱状体;复合地基不仅奂中度大幅度提     

激光扫描淀积原位生长高TC超导薄膜

用激光束扫描淀积的方法，成功地在ＺｒＯ２（Ｙ），ＬａＡｌＯ３基片原位生长高质量的ＹＢａ２Ｃｕ３Ｏ７－ｘ高温超导薄膜，其临界温度达到９０Ｋ以上，ＳＥＭ及ＸＲＤ分析表明，薄膜沿Ｃ轴择优外延生长，其结晶性很好，表现光滑均匀。     

Discussion on the cantilever casting construction method of concrete crack prevention and control

随着我国建设高峰的来临,悬浇法施工混凝土桥梁越来越多,相伴而来的桥梁混凝土开裂事故也越来越多.通过对施工工艺不当所造成的裂纹原因分析,制定了切实可行的预防及处理措施,对以后同类桥梁施工具有指导意义.     

长江下游火山岩的二个变异趋势及其形成机制

长江下游地区若干盆地不同旋回火山岩的化学成分存在２个不同的变异趋势，即富硅趋势和富钾趋势。富硅趋势主要由分离结晶作用形成的。富钾趋势的成因较为复杂。庐枞富钾趋势的形成与分离结晶作用有关，溧水富钾趋势涉及分离结晶与混染作用。而宁芜富钾岩石是由独立的母岩浆形成的。