Clinical trials of MRI-based immune cell imaging: challenges and perspectives

Immune cell-based therapies, such as chimeric antigen receptor T cells (CAR T) therapies and dendritic cell (DC) vaccines are producing tremendous opportunities...     

Photocatalytic conversion of CO to fuels with water by B-doped graphene/g-C3N4 heterostructure

Photocatalytic reduction of carbon monoxide (CO) is a promising route to the production of high-value chemicals and fuels,as a supplement to high energy-input F...     

Hybrid memristor-CMOS neurons for in-situ learning in fully hardware memristive spiking neural networks

Spiking neural network,inspired by the human brain,consisting of spiking neurons and plastic synapses,is a promising solution for highly efficient data processi...     

Platelet-derived growth factor receptor beta identifies mesenchymal stem cells with enhanced engraftment to tissue injury and pro-angiogenic property

Mesenchymal stem cells (MSCs) are heterogeneous likely consisting of subpopulations with various therapeutic potentials. Here we attempted to acquire a subset of MSCs with enhanced effect in wound healing. We found that human placental MSCs expressing platelet-derived growth factor (PDGF) receptor (PDGFR)-β exhibited greater proliferation rates and generated more colony-forming unit-fibroblast (CFU-F), compared to PDGFR-β^? MSCs. Notably, PDGFR-β⁺ MSCs expressed higher levels of pro-angiogenic factors such as Ang1, Ang2, VEGF, bFGF and PDGF. When 10⁶ GFP-expressing MSCs were topically applied into excisional wounds in mice, PDGFR-β⁺ MSCs actively incorporated into the wound tissue, resulting in enhanced engraftment (3.92 ± 0.31 × 10⁵ remained in wound by 7 days) and accelerated wound closure; meanwhile, PDGFR-β^? MSCs tended to remain on the top of the wound bed with significantly fewer cells (2.46 ± 0.26 × 10⁵) engrafted into the wound, suggesting enhanced chemotactic migration and engraftment of PDGFR-β⁺ MSCs into the wound. Real-Time PCR and immunostain analyses revealed that the expression of PDGF-B was upregulated after wounding; transwell migration assay showed that PDGFR-β⁺ MSCs migrated eightfold more than PDGFR-β^? MSCs toward PDGF-BB. Intriguingly, PDGFR-β⁺ MSC-treated wounds showed significantly enhanced angiogenesis compared to PDGFR-β^? MSC- or vehicle-treated wounds. Thus, our results indicate that PDGFR-β identifies a subset of MSCs with enhanced chemotactic migration to wound injury and effect in promoting angiogenesis and wound healing, implying a greater therapeutic potential for certain diseases.     

Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src

Apolipoprotein CIII (ApoCIII) not only serves as an inhibitor of triglyceride hydrolysis but also participates in diabetes-related pathological events such as hyperactivation of voltage-gated Ca²⁺ (Ca_V) channels in the pancreatic β cell. However, nothing is known about the molecular mechanisms whereby ApoCIII hyperactivates β cell Ca_V channels. We now demonstrate that ApoCIII increased Ca_V1 channel open probability and density. ApoCIII enhanced whole-cell Ca²⁺ currents and the Ca_V1 channel blocker nimodipine completely abrogated this enhancement. The effect of ApoCIII was not influenced by individual inhibition of PKA, PKC, or Src. However, combined inhibition of PKA, PKC, and Src counteracted the effect of ApoCIII, similar results obtained by coinhibition of PKA and Src. Moreover, knockdown of β1 integrin or scavenger receptor class B type I (SR-BI) prevented ApoCIII from hyperactivating β cell Ca_V channels. These data reveal that ApoCIII hyperactivates β cell Ca_V1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.     

中国现代毒理学的形成与发展

毒理学是关系人类健康的一门学科,人类与毒物斗争的历史是人类文明史中重要的篇章.生物学研究的每一次进展都使得毒理学产生新飞跃,从五四运动至今的90多年内,我国现代毒理学发展经历了起步、取得阶段性成果和开拓创新三个不同的发展阶段.     

提高水泥粉磨能效的探索

水泥粉磨系统是水泥生产过程中的重要环节.在保证水泥质量的情况下,最大限度地降低粉磨系统的能耗对于节约能源及提高企业经济效益具有重要的现实意义.本文介绍了目前水泥粉磨设备的选型情况,并提出选用立磨终粉磨系统将成为水泥粉磨的发展趋势.     

河曲电厂空预器差压大的原因及处理

空预器是锅炉的重要设备之一,由于我国能源紧缺,火电厂所烧煤质越来越差,远远偏离了设计煤种,造成空预器三分仓回转式空气预热器堵灰,文章对造成烟气侧进出口差压大的原因进行了细致的分析,提供了河曲电厂空预器堵灰时空预器差压的详细资料,并介绍了采取的防范措施.     

Analysis of Ultra - wideband Wireless Communications Technology Development

超宽带无线通信技术是一种具有高速、低成本和低能耗特点的无线通信技术,该技术的发展对于解决短距离内数据高速度无线传输具有重要的意义.文章拟从概念、特点、发展等方面对之进行论述.     

Hwasun County countryside winter heating Exploration and Research

近年来,和顺县委、县政府秉持“和民心、顺民意”的发展理念,急群众所急,想群众所想,把解决乡村冬季取暖工作放在新农村建设的首位,经广大干部群众和科技人员的共同努力,截至目前,取得了非常满意的成绩.已经推广的吊炕和正在推广的农户地暖,很好地解决了乡村冬季取暖的问题,为全省乃至全国有效利用农村可再生能源、促进节能减排、改善生态环境开辟出了一条新路子.