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911.
Two careers, in industry and in university teaching at postgraduate level, have led to the development of Soft Systems Methodology (SSM) in a 30-year program of action research. The most cogent comments on SSM come from reflective practitioners, and in this symposium I have asked eight such users of SSM to reflect on their experience and to address the question of what it is that happens when the approach is used in real-world problem situations. Their responses reflect their different backgrounds, experience, and ways of working, but a broad general picture emerges. This suggests that SSM (whose process does not necessarily have to be made explicit to participants in a study) can engender a process of on-going (cyclic) coherent structured learning which feels natural, and which can surface previously unexamined assumptions, thus creating an arena in which accommodations can emerge which enable and motivate "action to improve" to be taken. 相似文献
912.
Structural change and the combination of forecasts 总被引:1,自引:0,他引:1
Forecasters are generally concerned about the properties of model-based predictions in the presence of structural change. In this paper, it is argued that forecast errors can under those conditions be greatly reduced through systematic combination of forecasts. We propose various extensions of the standard regression-based theory of forecast combination. Rolling weighted least squares and time-varying parameter techniques are shown to be useful generalizations of the basic framework. Numerical examples, based on various types of structural change in the constituent forecasts, indicate that the potential reduction in forecast error variance through these methods is very significant. The adaptive nature of these updating procedures greatly enhances the effect of risk-spreading embodied in standard combination techniques. 相似文献
913.
914.
Peter L. Jørgensen 《Cellular and molecular life sciences : CMLS》1971,27(5):527-528
Zusammenfassung Nach Uninephrektomie und bilateraler Adrenalektomie entsteht eine Dissoziation zwischen der Nierenvergrösserung und der (Na++K+)-ATPase Aktivität. Es besteht wahrscheinlich kein Zusammenhang zwischen der Nierenvergrösserung und der Induktion von (Na++K+)-ATPase. Auch in der vergrösserten Niere sind die Nebennierenhormone notwendig, um die (Na++K+)-ATPase zu erhalten.
The work was supported by a grant from P. Carl Petersen's Fund. Mrs.Birthe Bagge Hansen provided excellent technical assistance. 相似文献
The work was supported by a grant from P. Carl Petersen's Fund. Mrs.Birthe Bagge Hansen provided excellent technical assistance. 相似文献
915.
916.
917.
Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma 总被引:20,自引:0,他引:20
918.
Lambrechts D Storkebaum E Morimoto M Del-Favero J Desmet F Marklund SL Wyns S Thijs V Andersson J van Marion I Al-Chalabi A Bornes S Musson R Hansen V Beckman L Adolfsson R Pall HS Prats H Vermeire S Rutgeerts P Katayama S Awata T Leigh N Lang-Lazdunski L Dewerchin M Shaw C Moons L Vlietinck R Morrison KE Robberecht W Van Broeckhoven C Collen D Andersen PM Carmeliet P 《Nature genetics》2003,34(4):383-394
919.
920.
Klausberger T Magill PJ Márton LF Roberts JD Cobden PM Buzsáki G Somogyi P 《Nature》2003,421(6925):844-848
Neural-network oscillations at distinct frequencies have been implicated in the encoding, consolidation and retrieval of information in the hippocampus. Some GABA (gamma-aminobutyric acid)-containing interneurons fire phase-locked to theta oscillations (4-8 Hz) or to sharp-wave-associated ripple oscillations (120-200 Hz), which represent different behavioural states. Interneurons also entrain pyramidal cells in vitro. The large diversity of interneurons poses the question of whether they have specific roles in shaping distinct network activities in vivo. Here we report that three distinct interneuron types--basket, axo-axonic and oriens-lacunosum-moleculare cells--visualized and defined by synaptic connectivity as well as by neurochemical markers, contribute differentially to theta and ripple oscillations in anaesthetized rats. The firing patterns of individual cells of the same class are remarkably stereotyped and provide unique signatures for each class. We conclude that the diversity of interneurons, innervating distinct domains of pyramidal cells, emerged to coordinate the activity of pyramidal cells in a temporally distinct and brain-state-dependent manner. 相似文献