全文获取类型
收费全文 | 5291篇 |
免费 | 38篇 |
国内免费 | 42篇 |
专业分类
系统科学 | 640篇 |
丛书文集 | 388篇 |
教育与普及 | 176篇 |
理论与方法论 | 10篇 |
现状及发展 | 417篇 |
研究方法 | 679篇 |
综合类 | 3059篇 |
自然研究 | 2篇 |
出版年
2021年 | 7篇 |
2016年 | 7篇 |
2015年 | 8篇 |
2014年 | 16篇 |
2013年 | 10篇 |
2012年 | 290篇 |
2011年 | 357篇 |
2010年 | 91篇 |
2009年 | 21篇 |
2008年 | 304篇 |
2007年 | 327篇 |
2006年 | 468篇 |
2005年 | 522篇 |
2004年 | 379篇 |
2003年 | 339篇 |
2002年 | 299篇 |
2001年 | 248篇 |
2000年 | 400篇 |
1999年 | 113篇 |
1998年 | 50篇 |
1997年 | 23篇 |
1996年 | 14篇 |
1995年 | 28篇 |
1994年 | 37篇 |
1993年 | 52篇 |
1992年 | 39篇 |
1991年 | 30篇 |
1990年 | 23篇 |
1989年 | 26篇 |
1988年 | 16篇 |
1987年 | 16篇 |
1986年 | 28篇 |
1985年 | 20篇 |
1984年 | 14篇 |
1983年 | 23篇 |
1982年 | 20篇 |
1981年 | 15篇 |
1980年 | 12篇 |
1979年 | 10篇 |
1971年 | 9篇 |
1970年 | 19篇 |
1966年 | 7篇 |
1959年 | 90篇 |
1958年 | 124篇 |
1957年 | 101篇 |
1956年 | 99篇 |
1955年 | 75篇 |
1954年 | 78篇 |
1948年 | 16篇 |
1946年 | 6篇 |
排序方式: 共有5371条查询结果,搜索用时 31 毫秒
51.
Ma Runnian Lei Sheping & Liu Naigong. Telecommunication Engineering Inst. Air Force Engineering Univ. Xi’an P. R. China . Key Lab of Information Sciences Engineering Dalian Univ. Dalian P. R. China . School of Humanity Law Economics Northwestern Polytechnical Univ. Xi''''an P. R. China . Science Inst. Air Force Engineering Univ. Xi’an P. R. China 《系统工程与电子技术(英文版)》2005,16(4)
1.INTRODUCTION DiscreteHopfieldneuralnetwork(DHNN)isoneof thefamousneuralnetworkswithawiderangeofap plications,suchascontentaddressablememory,pat ternrecognition,andcombinatorialoptimiza tion[1~5].ThestabilityofDHNNmeansthatevery trajectorymustconvergetowardsanequilibrium point,oralimitcycle.Becausethestabilityof DHNNisthefoundationofthenetwork’sapplica tionsandisthemostbasicandimportantproblem,thestabilityanalysisoftheDHNNhasattractedcon siderableinterest.Manyresearchershavefocu… 相似文献
52.
Chang Wang Chongwo Li Qingzhu JiaCollege of Material Science & Chemical Engineering Tianjin University of Science & Technology Dagunan Road Tianjin City P.R. China 《天津科技大学学报》2004,19(Z2)
INTRODUCTIONPlant consists essentially of three main polymers:lignin, cellulose, and hemicellulose, which are themost abundant and renewable hydrocarbon resourceson the earth. The annual yield of rice straw, wheatstraw, bagasse, reed, and bamboo in our country hasexceeded 1 billion tons. 30% of the yield of ricestraw and wheat straw are used for papermaking, which occupy 70-80% of the raw material. However, it is the difficulty in papermaking waste liquid treatment as well as the lack of c… 相似文献
53.
由于大气气溶胶影响着地球辐射总量的平衡与能量的估算, 有机化合物作为气溶胶和云凝结核(cloud condensation nuclei, CCN)的重要组成成分, 其重要性已经越来越引起科学家们的重视. 而低分子量二元羧酸(low molecular weight dicarboxylic acids, LMWDCA)作为大气(包括云和雾)中气溶胶的重要成分,其在大气中的传输与转化过程中的作用尤其是对冰核(ice nuclei, IN)核化过程的影响已经成为当前的一个重要的前沿科学研究领域. 本研究利用麦吉尔大学的冻结核记数仪分别测量了不同pH的水溶液(超纯净水与自来水)中单纯态的与混合态的低分子量二元羧酸(C2-C6)液滴的冻结温度. 结果显示, 低分子量二元羧酸(C2-C6)自来水溶液的冻结温度明显的高于其相应的超纯净水溶液. 不同混合态的二元羧酸(C2-C6)的纯净水和自来水溶液液滴的平均冻结温度范围分别是: (-24.1±2.8)~(-21.3±3.9)℃和(-10.2±2.2)~(-9.5±2.2)℃, 而所测对照水(超纯净水与自来水)溶液液滴的平均冻结温度则分别是(-22.6±3.5)和(-11.2±2.4)℃. C2-C6二元羧酸的加入对于水溶液液滴的冻结温度增高的促进作用并不显著. 相似文献
54.
Omar K. Matar Panagiota Angeli Geoffrey F. Hewitt E. Susana Pérez de Ortiz 《清华大学学报》2006,11(2):202-206
Introduction Liquid-liquid dispersions in agitated vessels are fre-quently used in the chemical industry for conducting operations such as solvent extraction and heterogene-ous reactions. In liquid-liquid two-phase flow systems, usually consisting of an a… 相似文献
55.
影响林木种子贮藏的因素 总被引:6,自引:2,他引:4
Ben S P Wang J Dale Simpson 《南京林业大学学报(自然科学版)》2006,30(1):1-7
为了每年提供造林新需的具有生活力的种子及长期保存种质资源,贮藏种子是必要的手段。种子寿命具有遗传性,且因树种而异。种子的贮藏特性可以分成5类:正常型、亚正常型、温带顽拗型、热带顽拗型和中间型。种子含水量和贮藏温度是影响种子贮藏是否成功的两个最重要因素。但因树种及其贮藏特性不同,种子含水量和贮藏温度的最适值也不同。为了保持正常型和亚正常型种子的生活力,这类种子必须密封贮藏;但对顽拗型种子,因其需要保持种子的代谢活性及要进行有氧呼吸,则需要气体交换。 相似文献
56.
Late Cretaceous-Cenozoic exhumation history of Tiantangzhai region of Dabieshan Orogen: Constraints from (U-Th)/He and fission track analysis 总被引:9,自引:0,他引:9
ZHOUZuyi XUChanghai P.W.Reiners YANGFengli R.A.Donelick 《科学通报(英文版)》2003,48(11):1151-1156
Integrated fission track and (U-Th)/He analysis is carried out on 6 apatite and 6 zircon samples from a near vertical section in The Tiantangzhai region at the core of the present Dabieshan orogen. The result shows that the region experienced cooling/exhumation during the Late Cretaceousand Early Tertiary period. Age-elevation relationships for different dating systems and different minerals suggest a pulse of rapid exhumation at ~110 Ma before present, preserved in the structurally highest samples. At lower elevations, ages begin to decrease with decreasing elevation, suggesting lower exhumation rates since 90 Ma. Two periods of different exhumation rates are identified since 90 Ma. The average apparent exhumation rate for the period of 43.4—22.5 is 0.062 km/Ma, whereas that for the period of 76.4—47.4 Ma is 0.039 km/Ma. 相似文献
57.
Nuclear transfer into mouse zygotes 总被引:6,自引:0,他引:6
58.
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy 总被引:5,自引:0,他引:5
Delmaghani S del Castillo FJ Michel V Leibovici M Aghaie A Ron U Van Laer L Ben-Tal N Van Camp G Weil D Langa F Lathrop M Avan P Petit C 《Nature genetics》2006,38(7):770-778
Auditory neuropathy is a particular type of hearing impairment in which neural transmission of the auditory signal is impaired, while cochlear outer hair cells remain functional. Here we report on DFNB59, a newly identified gene on chromosome 2q31.1-q31.3 mutated in four families segregating autosomal recessive auditory neuropathy. DFNB59 encodes pejvakin, a 352-residue protein. Pejvakin is a paralog of DFNA5, a protein of unknown function also involved in deafness. By immunohistofluorescence, pejvakin is detected in the cell bodies of neurons of the afferent auditory pathway. Furthermore, Dfnb59 knock-in mice, homozygous for the R183W variant identified in one DFNB59 family, show abnormal auditory brainstem responses indicative of neuronal dysfunction along the auditory pathway. Unlike previously described sensorineural deafness genes, all of which underlie cochlear cell pathologies, DFNB59 is the first human gene implicated in nonsyndromic deafness due to a neuronal defect. 相似文献
59.
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency 总被引:13,自引:0,他引:13
Irwin WA Bergamin N Sabatelli P Reggiani C Megighian A Merlini L Braghetta P Columbaro M Volpin D Bressan GM Bernardi P Bonaldo P 《Nature genetics》2003,35(4):367-371
Collagen VI is an extracellular matrix protein that forms a microfilamentous network in skeletal muscles and other organs. Inherited mutations in genes encoding collagen VI in humans cause two muscle diseases, Bethlem myopathy and Ullrich congenital muscular dystrophy. We previously generated collagen VI-deficient (Col6a1-/-) mice and showed that they have a muscle phenotype that strongly resembles Bethlem myopathy. The pathophysiological defects and mechanisms leading to the myopathic disorder were not known. Here we show that Col6a1-/- muscles have a loss of contractile strength associated with ultrastructural alterations of sarcoplasmic reticulum (SR) and mitochondria and spontaneous apoptosis. We found a latent mitochondrial dysfunction in myofibers of Col6a1-/- mice on incubation with the selective F1F(O)-ATPase inhibitor oligomycin, which caused mitochondrial depolarization, Ca2+ deregulation and increased apoptosis. These defects were reversible, as they could be normalized by plating Col6a1-/- myofibers on collagen VI or by addition of cyclosporin A (CsA), the inhibitor of mitochondrial permeability transition pore (PTP). Treatment of Col6a1-/- mice with CsA rescued the muscle ultrastructural defects and markedly decreased the number of apoptotic nuclei in vivo. These findings indicate that collagen VI myopathies have an unexpected mitochondrial pathogenesis that could be exploited for therapeutic intervention. 相似文献
60.
Purification and cloning of amyloid precursor protein beta-secretase from human brain 总被引:40,自引:0,他引:40
Sinha S Anderson JP Barbour R Basi GS Caccavello R Davis D Doan M Dovey HF Frigon N Hong J Jacobson-Croak K Jewett N Keim P Knops J Lieberburg I Power M Tan H Tatsuno G Tung J Schenk D Seubert P Suomensaari SM Wang S Walker D Zhao J McConlogue L John V 《Nature》1999,402(6761):537-540
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment. Cleavage of the C-terminal fragment by gamma-secretase(s) leads to the formation of Abeta. The pathogenic mutation K670M671-->N670L671 at the beta-secretase cleavage site in APP, which was discovered in a Swedish family with familial Alzheimer's disease, leads to increased beta-secretase cleavage of the mutant substrate. Here we describe a membrane-bound enzyme activity that cleaves full-length APP at the beta-secretase cleavage site, and find it to be the predominant beta-cleavage activity in human brain. We have purified this enzyme activity to homogeneity from human brain using a new substrate analogue inhibitor of the enzyme activity, and show that the purified enzyme has all the properties predicted for beta-secretase. Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase. 相似文献