Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors

The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.     

An Adaptive Identification and Control Scheme Using Radial Basis Function Networks

1.INTaODUCTIONThemultilayerfeedforwardneuralnetworks(MFNN)hasbeenwidelyappliedinmanyfieldssuchaspatternrecognition,nonlinearoptimization,systemidentificationandcontrol.Thesimpleback-propagation(BP)learningalgorithmisusuallyadoptedtoupdateitsweights.TheBPalgorithm,however,suffersdrawbacksofslowconvergenceandunpredictablesolutionsduringlearning.Althoughmailyapproachessuchasvariablestepsize,conjugategradient,pseudo-Newtonmethods[4]andothermethods[3,10],havebeendevelopedtoovercometheproble…     

野生千层塔的人工驯化栽培研究

分析了人工栽培条件下,千层塔不同海拔、土壤类型、遮阳度、移栽密度、收获时期和收获方式等处理的产量数据,筛选出千层塔最适宜的生态环境和栽培方法,形成了千层塔林药套种人工栽培技术优化组合,其产量达到1 556.33 kg/667 m2,对千层塔药材通过人工训化栽培进行规模化生产具有重要意义.     

θ环填料塔中单乙醇胺吸收CO2传质性能研究

在乱堆θ环不锈钢填料的自制填料塔中,使用单乙醇胺(MEA)作为吸收剂,研究MEA脱除CO2的去除率和总体积传质系数KGav,考察了贫液中CO2负载量、吸收剂浓度、液体流量、吸收温度等不同参数对总体积传质系数的影响.实验结果表明,KGav随贫液中CO2负载量的增大而减小,随吸收剂浓度、液体流量的增大而增大;且进料温度在3...     

满足圆形极点、方差指标与H∞性能约束的满意容错控制

对一类具有范数有界不确定性的线性连续系统,研究了当执行器发生故障时的静态输出反馈满意容错控制问题。在更实际、更一般的执行器连续增益故障模型下,所设计的控制器确保闭环系统同时满足期望的区域极点指标、稳态方差指标和H∞范数指标约束。同时分析了容错控制中三类期望指标的相容性,并给出了静态输出反馈满意容错控制器存在的充分条件和设计方法。仿真算例验证了方法的有效性,并且通过与不考虑故障的系统比较,进一步说明对系统进行满意容错控制的必要性。     

基于车轮减速度及滑移率的ABS联合仿真研究

将多体系统动力学与智能控制理论相结合对汽车制动防抱死控制系统进行了研究,利用ADAMS/CAR建立了汽车整车的多体力学模型, 模型包含了前后悬架、动力总成,转向系统,稳定杆,制动系,轮胎力学模型以及车身,同时也考虑了轮胎、衬套、弹簧、减震器等部件的非线性,准确地表达了车辆的动态特性;利用Matlab/Simulink建立了车轮减速度及滑移率的双门限控制ABS模型,利用ADAMS/Control接口进行模型的集成、协同仿真,并将仿真结果与常规制动时的仿真结果进行了比较和分析,仿真反映出双门限值控制在整车制动防抱死控制系统上的应用效果,结果表明该控制算法实用性较强.     

Have national trends in fertility between 1986 and 2006 occurred evenly across England and Wales?

During the past 20 years fertility patterns within England and Wales have changed considerably. The total fertility rate experienced a prolonged decline during the 1990s and hit a record low in 2001. Since then the level of fertility has increased fairly rapidly. Over the two decades, fertility has been constantly increasing at ages above 30, and as a consequence the mean age of motherhood has been rising. This article explores fertility trends within statistical regions and local authorities to improve our understanding of changes in fertility at the subnational level between 1986 and 2006.     

分布式调度三级CLOS网络中交换机制的选择

以分布式调度三级Clos网络为重点,对定长信元和变长分组两种交换方式性能和实现成本进行了对比分析;通过对网络第一级负载分配原则的理论分析,给出了变长分组交换方式下网络稳定性的条件,利用仿真分析对比了两种交换方式的时延特性.给出了分布式调度三级Clos网络中交换机制的选择原则.     

GROUP-BUYING ONLINE AUCTION AND OPTIMAL INVENTORY POLICY IN UNCERTAIN MARKET

In this paper we consider a group-buying online auction (GBA) model for a monopolistic manufacturer selling novel products in the uncertain market. Firstly, we introduce the bidder's dominant strategy, after which we optimize the GBA price curve and the production volume together. Finally, we compare the GBA with the traditional posted pricing mechanism and find that the GBA is highly probable to be advantageous over the posted pricing mechanism in some appropriate market environments.     

STABILITY CRITERIA FOR A CLASS OF UNCERTAINSYSTEMS WITH TIME—DELAY

Some stability criteria are obtained for a class of uncertain systems with time-delay usingLyapunov functional and analytic techniques. It is easy to check the criteria by making use of theboundedness of the uncertainties.