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51.
人们改善环氧树脂基复合材料的脆性通常只改善环氧树脂基体和增强纤维间的界面,提高环氧树脂韧性的另一种常用方法是添加初始相容性良好的热塑性树脂如聚醚酰亚胺,在某一转化率(取决于体系的组成和反应温度)时体系发生相转变,体系最终的形态由相转变速率和环氧树脂反应速度所控制。本文作者研究了两种增强纤维(玻璃纤维和碳纤维)对不同环氧树脂/聚醚酰亚爱体系形态形成的影响,结果发现体系中纤维的存在不会影响基体相分离过程,但会改变体系的最终形态;形态的变化与纤维的品种关系不大;基体中不同组分的粘度是影响复合材料形态形成的关键因素。 相似文献
52.
A role for mitochondria in NLRP3 inflammasome activation 总被引:2,自引:0,他引:2
An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host 'danger', including infection and metabolic dysregulation. Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (ROS) derived from an uncharacterized organelle. Here we show that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome. Resting NLRP3 localizes to endoplasmic reticulum structures, whereas on inflammasome activation both NLRP3 and its adaptor ASC redistribute to the perinuclear space where they co-localize with endoplasmic reticulum and mitochondria organelle clusters. Notably, both ROS generation and inflammasome activation are suppressed when mitochondrial activity is dysregulated by inhibition of the voltage-dependent anion channel. This indicates that NLRP3 inflammasome senses mitochondrial dysfunction and may explain the frequent association of mitochondrial damage with inflammatory diseases. 相似文献
53.
LQ YingzhongInst. for Techno-Economics Energy System Analysis. P.O. Box Beijing China 《系统工程与电子技术(英文版)》1991,(1)
The long-term energy demand in China and the-Chinese share in global CO2 emission are forecasted on the basis of scenarios of population growth and economy development up to 2050 proposed in view of the interaction of energy, economy, environment and social development. The total energy demand in 2050 will reach 4.4~ 5.4 billion tce. It is shown in energy supply analysis that coal is China's major energy in primary energy supply. The share of CO2 emission in the future Chinese energy system will be out of proportion to its energy consumption share because of the high persentage of coal to be consumed. It will reach about 27%. The nuclear option which would replace 30.7% of coal in the total primary energy supply will reduce the share by 9.8%. So the policy considerations on the future Chinese energy system is of great importance to the global CO2 issues. 相似文献
54.
Lijie Zhang Jianguo Huang Yong Jin Yunshan Hou Min Jiang Qunfei Zhang .College of Marine Northwestern Polytechnical University Xi’an P.R.China .Yichang Testing Technique Research Institute Yichang 《系统工程与电子技术(英文版)》2010,21(2):186-190
A new monostatic army system taking advantage of diverse waveforms to improve the performance of underwater target localization is proposed.Unlike the coherent signals between different elements in common active array,the transmitted signals from different elements here are spatially orthogonal waveforms which allow for array processing in the transit mode and result in an extension of array aperture.The mathematical derivation of Capon estimator for this sonar system is described in detail.And the performance of this orthogonal-waveform based sonar is analyzed and compared with that of its phased-array counterpart by water tank experiments.Experimental results show that this sonar system could achieve 12 dB-15 dB additional array gain over its phased-array counterpart,which means a doubling of maximum detection range.Moreover,the angular resolution is significantly improved at lower SNR. 相似文献
55.
Bian Hongwei~ Jin Zhihua~ & Tian Weifeng~ . Dept. of Information Measurement Technology Instruments Shanghai Jiaotong Univ. Shanghai P. R. China . Dept. of Electrical Engineering of Naval Univ. of Engineering Wuhan ) 《系统工程与电子技术(英文版)》2006,17(3):502-508
1 .INTRODUCTIONInertial navigation system(INS) and Global posi-tioning system ( GPS) are two major navigationsystems now widely usedfor marine applications a-round the world. Considering both systems pos-sess complementary working characteristics , abooming attention is focused on finding effectivemethods to combine the two different systems toconstituteintegrated navigation system with higheraccuracy and better performance .Information likeGPS position and velocity are often chosen as… 相似文献
56.
Zhou XianminShanghai Research & Development Centre Guil in Road Shanghai P.R.China 《系统工程与电子技术(英文版)》1993,(4)
Computer simulation models may by used to gain further information about missile performance variability. Model validation is an important aspect of the test program for a missile system. Validation provides a basis for confidence in the model's results and is a necessary step if the model is to be used to draw inference about the behavior of the real missile. This paper is a review of methods useful for validation of computer simulation models of missile systems and provides a new method with high degree of confidence for validation of computer simulation models of missile systems. Some examples of the use of the new method in validating computer simulation models are given. 相似文献
57.
58.
Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms 总被引:15,自引:0,他引:15
Orr JC Fabry VJ Aumont O Bopp L Doney SC Feely RA Gnanadesikan A Gruber N Ishida A Joos F Key RM Lindsay K Maier-Reimer E Matear R Monfray P Mouchet A Najjar RG Plattner GK Rodgers KB Sabine CL Sarmiento JL Schlitzer R Slater RD Totterdell IJ Weirig MF Yamanaka Y Yool A 《Nature》2005,437(7059):681-686
Today's surface ocean is saturated with respect to calcium carbonate, but increasing atmospheric carbon dioxide concentrations are reducing ocean pH and carbonate ion concentrations, and thus the level of calcium carbonate saturation. Experimental evidence suggests that if these trends continue, key marine organisms--such as corals and some plankton--will have difficulty maintaining their external calcium carbonate skeletons. Here we use 13 models of the ocean-carbon cycle to assess calcium carbonate saturation under the IS92a 'business-as-usual' scenario for future emissions of anthropogenic carbon dioxide. In our projections, Southern Ocean surface waters will begin to become undersaturated with respect to aragonite, a metastable form of calcium carbonate, by the year 2050. By 2100, this undersaturation could extend throughout the entire Southern Ocean and into the subarctic Pacific Ocean. When live pteropods were exposed to our predicted level of undersaturation during a two-day shipboard experiment, their aragonite shells showed notable dissolution. Our findings indicate that conditions detrimental to high-latitude ecosystems could develop within decades, not centuries as suggested previously. 相似文献
59.
Bone marrow cells regenerate infarcted myocardium 总被引:455,自引:0,他引:455
Orlic D Kajstura J Chimenti S Jakoniuk I Anderson SM Li B Pickel J McKay R Nadal-Ginard B Bodine DM Leri A Anversa P 《Nature》2001,410(6829):701-705
Myocardial infarction leads to loss of tissue and impairment of cardiac performance. The remaining myocytes are unable to reconstitute the necrotic tissue, and the post-infarcted heart deteriorates with time. Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. This high degree of stem cell plasticity prompted us to test whether dead myocardium could be restored by transplanting bone marrow cells in infarcted mice. We sorted lineage-negative (Lin-) bone marrow cells from transgenic mice expressing enhanced green fluorescent protein by fluorescence-activated cell sorting on the basis of c-kit expression. Shortly after coronary ligation, Lin- c-kitPOS cells were injected in the contracting wall bordering the infarct. Here we report that newly formed myocardium occupied 68% of the infarcted portion of the ventricle 9 days after transplanting the bone marrow cells. The developing tissue comprised proliferating myocytes and vascular structures. Our studies indicate that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease. 相似文献
60.
Jonker JW Suh JM Atkins AR Ahmadian M Li P Whyte J He M Juguilon H Yin YQ Phillips CT Yu RT Olefsky JM Henry RR Downes M Evans RM 《Nature》2012,485(7398):391-394
Although feast and famine cycles illustrate that remodelling of adipose tissue in response to fluctuations in nutrient availability is essential for maintaining metabolic homeostasis, the underlying mechanisms remain poorly understood. Here we identify fibroblast growth factor 1 (FGF1) as a critical transducer in this process in mice, and link its regulation to the nuclear receptor PPARγ (peroxisome proliferator activated receptor γ), which is the adipocyte master regulator and the target of the thiazolidinedione class of insulin sensitizing drugs. FGF1 is the prototype of the 22-member FGF family of proteins and has been implicated in a range of physiological processes, including development, wound healing and cardiovascular changes. Surprisingly, FGF1 knockout mice display no significant phenotype under standard laboratory conditions. We show that FGF1 is highly induced in adipose tissue in response to a high-fat diet and that mice lacking FGF1 develop an aggressive diabetic phenotype coupled to aberrant adipose expansion when challenged with a high-fat diet. Further analysis of adipose depots in FGF1-deficient mice revealed multiple histopathologies in the vasculature network, an accentuated inflammatory response, aberrant adipocyte size distribution and ectopic expression of pancreatic lipases. On withdrawal of the high-fat diet, this inflamed adipose tissue fails to properly resolve, resulting in extensive fat necrosis. In terms of mechanisms, we show that adipose induction of FGF1 in the fed state is regulated by PPARγ acting through an evolutionarily conserved promoter proximal PPAR response element within the FGF1 gene. The discovery of a phenotype for the FGF1 knockout mouse establishes the PPARγ–FGF1 axis as critical for maintaining metabolic homeostasis and insulin sensitization. 相似文献