基于水-岩相互作用的富水断层破碎带隧道突涌灾害演化特征

为研究开挖卸荷和水力荷载耦合作用下富水断层破碎带隧道突涌灾害演化特征,以沈白高铁西谷隧道工程为依托,考虑不同富水破碎带构造形式及地下水赋存特征,开展隧道突涌灾害演化过程研究。基于水-岩相互作用原理,建立三维离散元粘合块体-裂隙流耦合模型,明确不同地质构造特征下的隧道突涌灾害模式,分析破碎岩体裂隙扩展和地下水渗流的时空演化规律。研究结论有:(1) 引入粘合块体模型和裂隙流组合模型,建立了富水断层破碎带水岩相互作用力学模型,再现了富水破碎带隧道突涌灾害演化过程。(2) 不同富水破碎带构造形式引起的突涌灾变模式差异显著,且具有不同的触发条件和表现形式。断层破碎带倾角为45°时,破碎岩体沿掌子面下部溜塌涌入隧道,倾角为90°时,围岩向掌子面挤出,倾角为-45°时,表现为拱顶围岩垮塌。(3)富水破碎带突涌灾害程度随着水头增大而加剧,其中倾角为-45°时,突涌灾害程度受水头高度的影响最显著,倾角为90°时,水头高度影响相对较弱,但突涌灾害程度最严重。     

基于交换式消息调度算法的FlexRay网络优化研究

汽车电子设备水平的提升对车载总线网络提出了很高的要求。而FlexRay网络因为其高速率、可靠性等特点成为了流行的车载通信协议。为满足网络发展的需求,设计了一种基于交换式FlexRay网络的调度算法,提出了一种可以准确计算静态段和动态段最坏情况响应时间的计算方法。通过仿真实验,验证了所提算法的网络传输速率提升了26%,时隙数量减少了44%,总线占用率降低了23%。从而进一步优化了FlexRay网络。     

解聚复肾宁对大鼠肾小球系膜细胞增殖和细胞周期的影响

目的 观察中药复方解聚复肾宁（JJFSN）对高耱环境下大鼠肾小球系膜细胞（mesangial cell,MC）增殖和细胞周期的影响.方法 以高糖诱导MC增殖,采用血清药理学方法制备不同浓度JJFSN舍药血清,加入培养液中,用MTT法检测细胞增殖,流式细胞技术检测细胞周期.结果 MTT显示：JJFSN含药血清可抑制高糖诱导的MC过度增殖（P＜0.05）,并且这种作用具有药物剂量和时间依赖关系.流式细胞技术分析表明：JJFSN可逆转高糖对细胞周期的影响,使G0/G1期细胞比例增加,S期细胞比例下降（P＜0.05） 在高浓度时还能促进MC细胞凋亡.结论 JJFSN可以通过调节细胞周期,促进细胞凋亡,从而抑制高糖诱导的MC过度增殖,这可能是JJFSN防治DN早期的作用杌理.     

Association analyses identify multiple new lung cancer susceptibility loci and their interactions with smoking in the Chinese population

To find additional susceptibility loci for lung cancer, we tested promising associations from our previous genome-wide association study (GWAS) of lung cancer in the Chinese population in an extended validation sample size of 7,436 individuals with lung cancer (cases) and 7,483 controls. We found genome-wide significant (P < 5.0 × 10(-8)) evidence for three additional lung cancer susceptibility loci at 10p14 (rs1663689, close to GATA3, P = 2.84 × 10(-10)), 5q32 (rs2895680 in PPP2R2B-STK32A-DPYSL3, P = 6.60 × 10(-9)) and 20q13.2 (rs4809957 in CYP24A1, P = 1.20 × 10(-8)). We also found consistent associations for rs247008 at 5q31.1 (IL3-CSF2-P4HA2, P = 7.68 × 10(-8)) and rs9439519 at 1p36.32 (AJAP1-NPHP4, P = 3.65 × 10(-6)). Four of these loci showed evidence for interactions with smoking dose (P = 1.72 × 10(-10), P = 5.07 × 10(-3), P = 6.77 × 10(-3) and P = 4.49 × 10(-2) for rs2895680, rs4809957, rs247008 and rs9439519, respectively). These results advance our understanding of lung cancer susceptibility and highlight potential pathways that integrate genetic variants and smoking in the development of lung cancer.     

Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

Schizophrenia is a severe mental disorder affecting ～1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.     

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

Through complementary application of SNP genotyping, whole-genome sequencing and imputation in 38,384 Icelanders, we have discovered a previously unidentified sick sinus syndrome susceptibility gene, MYH6, encoding the alpha heavy chain subunit of cardiac myosin. A missense variant in this gene, c.2161C>T, results in the conceptual amino acid substitution p.Arg721Trp, has an allelic frequency of 0.38% in Icelanders and associates with sick sinus syndrome with an odds ratio = 12.53 and P = 1.5 × 10?2?. We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant.     

亚微米工艺流程研究

介绍了在中国华晶中央研究所１．０微米工艺线上所开发的亚微米（０．８μｍ）工艺流程,重点介绍了０．８μｍ器件结构、工艺流程图、关键工艺设计以及用此流程制造出的０．８μｍ器件的各项ＰＣＭ参数。     

脉动流条件下圆柱绕流特性研究

该文数值研究了脉动流条件下圆柱绕流场特性,对涡量分布、升阻力系数、升力系数频谱特性等进行了分析。结果表明,脉动流作用会使圆柱尾涡剪切层变薄,提高脉动频率使尾涡长度变短、脱离加快,提高无量纲脉动振幅使主导涡的脱落速度降低,使旋涡生成区域更靠近圆柱表面;脉动频率与无量纲脉动振幅的增大使升、阻力系数的振幅均增大,而且与升力系数相比,阻力系数的振幅更大,变化更快;升力系数频谱图存在多个主频,包括旋涡脱落频率和相位叠加频率,其中旋涡脱落频率的振幅随着脉动频率的增加而减小,随着无量纲脉动振幅的增加而增加。     

全尾砂新型充填胶凝材料开发及其水化机理探讨

针对司家营铁矿全尾砂,利用石灰、脱硫石膏、矿渣等固体废弃物开展替代水泥的新型充填胶凝材料试验研究,并通过电镜扫描(SEM)和X射线衍射(XRD)分析,研究新型充填胶凝材料激发剂的水化机理,确定激发剂优化配比。研究表明,当料浆质量分数为68%、胶砂比为1∶8、石灰质量分数为3.5%、脱硫石膏质量分数为16.0%时能够满足司家营铁矿南区嗣后充填法采矿对充填体强度的要求。结果显示,新型充填胶凝材料胶砂体与水泥胶砂体相比,结构更致密、产状更粗大,水化产物主要为AFt晶体和无定型C-S-H凝胶,从而大幅度提高了新型充填胶凝材料胶砂体的龄期强度。