兽药添加剂喹乙醇对水生生物的毒理学研究

兽药添加剂喹乙醇是一种在畜禽及水产养殖中应用广泛的促生长剂 ,但其安全性仍存在较大争议 ,使用不当或过量使用会对环境构成潜在危害 .采用斑马鱼和鲤鱼作为生物材料 ,分别研究了兽药添加剂喹乙醇对斑马鱼的急性毒性、对斑马鱼胚胎发育的影响及对鲤鱼肾细胞DNA的损伤 .急性毒性试验表明 ,96hrLC50 为 1 996.87mg/L ;胚胎发育试验实验结果表明 ,96hrEC50 为2 2 1 .2 0mg/L ;单细胞凝胶电泳试验结果表明 ,喹乙醇能引起较大的DNA损伤 ,与空白对照相比有极显著性差异 (P <0 .0 1) ,并在设定的剂量范围内呈现一定的剂量效应关系     

三车道元胞自动机交通流模型研究

在Nagel-Schrekenberg（NS）元胞自动机交通流模型的基础上，提出了一种高速公路三车道元胞自动机交通流模型．该模型中所有的车辆均遵循相同的演化规则，并允许车辆以一定概率换道．根据计算机数值模拟．研究了车辆减速概率、换道概率对车流量、车道利用率影响关系，结果表明，在相同情况下，此模型所得到的基本图显示出交通流量比单车道NS模型大，并且发现减少不必要的车辆换道行为可以使驾驶更安全．这些研究为管理三车道的道路系统提供了一定的参考依据．     

P-RC APMP PULPING OF THE TRIPLOID OF POPULUS TOMENTOSA

The technology parameters of P-RC APMP process of the triploid of populus tomentosa and the the comparison of P-RC APMP with one and two stage f pretreatment were investigated in this paper. The results showed that in the chemical pretreatment the s that affected the pulp qualities. The charge of NaOH,y in the first stage of chemical pretreatment,was related to pulp strength. The charge of H2O2 tant pulp.In addition, the ratio of NaOH to H2O2 and the on of chemicals in the first and second stage of impregnation also affected the pulp qualities. The and two-stage P-RC APMP pulp illustrated that the ulp had better brightness and breaking length, lower light scatting coefficient and opacity.     

林白小说中的女妖原型及其文化意义

用原型批评的方法解读女作家林白的小说，分析归纳了女妖神话在其作品中的四种移植类型，分别是“沙街”女妖、都市复仇女神、乡村性爱女妖和“银角”变异女妖。这四种类型代表她不同时期的创作理念的变化：从早期的唯美的女性独语，到中期创作表现出激进的女性主义写作，再到新世纪以来民间女性立场的确立和对消费文化下女性存在的独特思考。因此，原型及其演变的追踪可看出林白作品独特的艺术魅力以及创作轨迹的变迁。     

中尼公路卡如滑坡成因分析和治理工程措施

以中尼公路卡如滑坡为例,详细地分析了该滑坡的变形特征及成因机制。研究表明,地形及滑坡体的物质组成特征是滑坡的地质基础,大量降雨是滑坡的促进因素,公路修建对滑坡前部的开挖是滑坡的直接诱发因素。针对卡如滑坡的特点,提出了相应的治理工程措施。     

激光相变热处理对TC４电子束焊缝残余应力的影响

利用CO２激光相变热处理技术对TC４钛合金电子束焊缝进行了处理,研究了激光功率、光斑直径、 辅助气体等激光工艺参数对电子束焊缝残余应力分布的影响。实验结果表明,激光相变热处理改善了焊缝残余 应力的分布,使焊缝表面残余应力由拉应力转变为压应力,其压应力值随着激光功率的增加而增大,随着激光 光斑直径的减小而增加;辅助气体为O２时残余压应力值比辅助气体为N２大３０～４０MPa,激光相变热处理显著 提高了TC４钛合金电子束焊缝的残余压应力及其使用寿命。     

均匀棒纯纵向运动初值问题混合有限元方法的H(div)模误差估计

笔者继续考虑均匀棒纯纵向运动初值问题的混合有限元方法[1],利用广义混合椭圆投影的误差估计,给出了H(div)模最优误差估计,使得该问题得到进一步的解决.     

Rolling-induced microstructure change in Zr_（65）Al_（7.5）Ni_（10）Cu_（12.5）Ag_5 bulk metallic glass

The microstructures and free-volume evolutions of as-cast and pre-annealed Zr65Al7.5Ni10Cu12.5Ag5 bulk metallic glasses during rolling deformation have been investigated. No phase transformation is detected in the as-cast/rolled specimen. However,the structural stability of the glass against plastic deformation is worse after pre-annealing,indicated by nanocrystallization in preannealed/rolled specimens with large deformation degrees. Moreover,with increasing deformation degree,the free-volume content in a pre-annealed/rolled specimen increases at a lower average rate than that in an as-cast/rolled specimen.     

Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor

The ubiquitylation of cell-cycle regulatory proteins by the large multimeric anaphase-promoting complex (APC/C) controls sister chromatid segregation and the exit from mitosis. Selection of APC/C targets is achieved through recognition of destruction motifs, predominantly the destruction (D)-box and KEN (Lys-Glu-Asn)-box. Although this process is known to involve a co-activator protein (either Cdc20 or Cdh1) together with core APC/C subunits, the structural basis for substrate recognition and ubiquitylation is not understood. Here we investigate budding yeast APC/C using single-particle electron microscopy and determine a cryo-electron microscopy map of APC/C in complex with the Cdh1 co-activator protein (APC/C(Cdh1)) bound to a D-box peptide at ～10 ? resolution. We find that a combined catalytic and substrate-recognition module is located within the central cavity of the APC/C assembled from Cdh1, Apc10--a core APC/C subunit previously implicated in substrate recognition--and the cullin domain of Apc2. Cdh1 and Apc10, identified from difference maps, create a co-receptor for the D-box following repositioning of Cdh1 towards Apc10. Using NMR spectroscopy we demonstrate specific D-box-Apc10 interactions, consistent with a role for Apc10 in directly contributing towards D-box recognition by the APC/C(Cdh1) complex. Our results rationalize the contribution of both co-activator and core APC/C subunits to D-box recognition and provide a structural framework for understanding mechanisms of substrate recognition and catalysis by the APC/C.