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51.
S Peña-Llopis S Vega-Rubín-de-Celis A Liao N Leng A Pavía-Jiménez S Wang T Yamasaki L Zhrebker S Sivanand P Spence L Kinch T Hambuch S Jain Y Lotan V Margulis AI Sagalowsky PB Summerour W Kabbani SW Wong N Grishin M Laurent XJ Xie CD Haudenschild MT Ross DR Bentley P Kapur J Brugarolas 《Nature genetics》2012,44(9):1072
52.
RK Koenekoop H Wang J Majewski X Wang I Lopez H Ren Y Chen Y Li GA Fishman M Genead J Schwartzentruber N Solanki EI Traboulsi J Cheng CV Logan M McKibbin BE Hayward DA Parry CA Johnson M Nageeb;Finding of Rare Disease Genes 《Nature genetics》2012,44(9):1035-1039
Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder. 相似文献
53.
Windus LC Chehrehasa F Lineburg KE Claxton C Mackay-Sim A Key B St John JA 《Cellular and molecular life sciences : CMLS》2011,68(19):3233-3247
Axons of primary olfactory neurons are intimately associated with olfactory ensheathing cells (OECs) from the olfactory epithelium until the final targeting of axons within the olfactory bulb. However, little is understood about the nature and role of interactions between OECs and axons during development of the olfactory nerve pathway. We have used high resolution time-lapse microscopy to examine the growth and interactions of olfactory axons and OECs in vitro. Transgenic mice expressing fluorescent reporters in primary olfactory axons (OMP-ZsGreen) and ensheathing cells (S100ß-DsRed) enabled us to selectively analyse these cell types in explants of olfactory epithelium. We reveal here that rather than providing only a permissive substrate for axon growth, OECs play an active role in modulating the growth of pioneer olfactory axons. We show that the interactions between OECs and axons were dependent on lamellipodial waves on the shaft of OEC processes. The motility of OECs was mediated by GDNF, which stimulated cell migration and increased the apparent motility of the axons, whereas loss of OECs via laser ablation of the cells inhibited olfactory axon outgrowth. These results demonstrate that the migration of OECs strongly regulates the motility of axons and that stimulation of OEC motility enhances axon extension and growth cone activity. 相似文献
54.
55.
Reported are 105 species of Scolytidae (Coleoptera) from Idaho. About one-third of these are rarely collected, of which 22 species are known from a single locality each. Twelve species reported from Idaho for the first time are: Carphoborus carri Swaine, C. sansoni Swaine, Phloeosinus hoferi Blackman, Conophthorus monophyllae Hopkins, Dryocoetes betulae Hopkins, Ips confuses (LeConte), Pityophthorus absonus Blackman, P. aquilus Blackman , P. blandus Blackman, P. deletus LeConte, P. sculptor Blackman, and Xyleborinus saxeseni (Ratzeburg). Significant extensions of the known distributions in Idaho are reported for seven other scolytids; Alniphagus aspericollis (LeConte), Dendroctonus murrayanae Hopkins, Phloeotribus lecontei Schedl, Procryphalus mucronatus (LeConte), Trypophloeus populi Hopkins, Xyleborus dispar (Fabricius), and X. intrusus Blandford. Xyleborus dispar especially needs study in anticipation that it may become increasingly important in Idaho fruit trees and other woody plants including ornamentals and shade trees. 相似文献
56.
Seedling size and survival in relation to summer drought were examined for Chrysothamnus nauseosus growing under field and greenhouse conditions. In the field, summer survival rates were less than 2% annually for the three years monitored. The effect of initial seedling height on subsequent survival was examined in both the field and greenhouse by grouping seedlings into live and dead categories on each census date and comparing initial heights for seedlings in these categories. For a majority of the census dates, the initial height of surviving seedlings was greater than the initial height of those that subsequently died (significant differences ranged from 1 to 8 mm), indicating that seedlings that were taller at the initiation of the drought period had a higher probability of survival. In the greenhouse, taller seedlings had greater shoot and root biomass and rooting depth. Seedlings that are larger (i.e., taller and have greater aboveground biomass) in late spring appear to have a higher probability of surviving summer drought due to greater rooting depth and hence increased access to moisture in deeper soil layers. Seed availability and safe sites for germination were probably not limiting since large numbers of seedlings successfully germinated in a patchy pattern during the study period. Seedling size and probability of survival were not related to either seedling density or the distance to nearest seedling neighbor. Survival through summer drought appears to be the main limitation to seedling recruitment in this population. 相似文献
57.
Mapping units were developed based on landform, soils, and plant communities for the 40,000 ha of salt desert vegetation located below the maximum level of pluvial Lake Gilbert in Grass Valley, Nevada. Lake plain, beach, and bar features of the pluvial lake provide the dominant landforms. Fine textured lake sediments have produced salt- and Na-affected soils. The distribution and structure of plant communities are related to depth of the groundwater table, fluctuations in this depth, and the salt content of the groundwater. Wind and water erosion combine to continually evolve new environments for colonization by plants in this ecosystem. 相似文献
58.
Two canids, Vulpes vulpes and Canis lupus , are recorded from shoreline deposits of Lake Bonneville in north central Utah. Both species are new records in the Pleistocene sediments of Utah and add to our scarce knowledge of the large carnivores that inhabited the shoreline environments of Lake Bonneville. 相似文献
59.
James E. Johnson 《西北部美国博物学家》2011,46(4)
Crayfish distribution and composition in Utah are poorly documented. Based upon limited collections, the native Pacifastacus gambelii is widespread and often abundant in the Bear and Weber river drainages and is occasionally represented in smaller tributaries to the Great Salt Lake and to the Raft River. Pacifastacus leniusculus was collected from Utah County and Procambarus clarkii from Tooele County; the origin of these populations is not known. The nonnative crayfish Orconectes virilis is currently abundant in the Virgin, Price, and Duchesne river basins and the Glen Canyon, Flaming Gorge, Deer Creek, and Starvation reservoirs; it is expanding in Huntington North, Scofield, and Willard reservoirs. Further work is required to develop a more complete inventory and monitor the impacts on aquatic ecosystems of expanding nonnative crayfish populations. Surreptitious stockings can be dealt with only if the public is made aware of the adverse consequences of ill-conceived introductions. 相似文献
60.
Timothy D. Hatten Norm Merz James B. Ding Johnson Chris Looney Travis Ulrich Scott Soults Roland Capilo Dwight Bergerone Paul Anders Philip Tanimoto Bahman Shafii 《西北部美国博物学家》2011,70(4)
The parasitic wasp Mymaromella pala Huber and Gibson (Hymenoptera: Mymarommatidae) was collected at 4 sites within a canyon reach of the Kootenai River in Lincoln County, Montana. This minute species has only recently been described, but it appears to have a large distribution throughout the United States and to be associated with upland and riparian forests. La avispa parasitaria Mymaromella pala Huber y Gibson (Hymenoptera: Mymarommatidae) se recolectó en cuatro sitios a lo largo de un cañón del Río Kootenai en Lincoln Co., MT. Hace poco que se describió esta especie diminuta, pero parece tener una distribución extensa en los EE.UU. y estar asociada con bosques altos y ribereños. 相似文献