Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

We developed a series of interrelated locus-specific databases to store all published and unpublished genetic variation related to hemoglobinopathies and thalassemia and implemented microattribution to encourage submission of unpublished observations of genetic variation to these public repositories. A total of 1,941 unique genetic variants in 37 genes, encoding globins and other erythroid proteins, are currently documented in these databases, with reciprocal attribution of microcitations to data contributors. Our project provides the first example of implementing microattribution to incentivise submission of all known genetic variation in a defined system. It has demonstrably increased the reporting of human variants, leading to a comprehensive online resource for systematically describing human genetic variation in the globin genes and other genes contributing to hemoglobinopathies and thalassemias. The principles established here will serve as a model for other systems and for the analysis of other common and/or complex human genetic diseases.     

基于干涉相位的虚假目标鉴别算法

以具有地面动目标指示(ground moving target indication, GMTI)能力的三天线合成孔径雷达(synthetic aperture radar, SAR)系统为对象,研究了虚假目标的鉴别问题。在虚假目标干扰原理和动目标检测技术的基础上,分析了目标信号和干扰信号的干涉相位特征;利用真假目标的干涉相位特征差异,提取了两种稳健的鉴别特征量,提出了一种基于干涉相位的虚假目标鉴别算法,给出了鉴别处理流程、算法的应用条件及计算量和复杂度;最后进行了仿真实验验证。理论分析和仿真实验均表明该鉴别算法的可行性和有效性。     

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets

We present the first analysis of the human proteome with regard to interactions between proteins. We also compare the human interactome with the available interaction datasets from yeast (Saccharomyces cerevisiae), worm (Caenorhabditis elegans) and fly (Drosophila melanogaster). Of >70,000 binary interactions, only 42 were common to human, worm and fly, and only 16 were common to all four datasets. An additional 36 interactions were common to fly and worm but were not observed in humans, although a coimmunoprecipitation assay showed that 9 of the interactions do occur in humans. A re-examination of the connectivity of essential genes in yeast and humans indicated that the available data do not support the presumption that the number of interaction partners can accurately predict whether a gene is essential. Finally, we found that proteins encoded by genes mutated in inherited genetic disorders are likely to interact with proteins known to cause similar disorders, suggesting the existence of disease subnetworks. The human interaction map constructed from our analysis should facilitate an integrative systems biology approach to elucidating the cellular networks that contribute to health and disease states.     

浅谈高校图书馆新馆建设的馆藏布局

以康大教育园图书馆为例,详细介绍了新馆建设中如何选择科学、实用的馆藏布局方案。     

从数学的特点看如何提升中学生学习数学的兴趣

著名数学家华罗庚在其《数学的用场与发展》一文中说“宇宙之大，粒子之微，火箭之速，华工之巧。地球之变，生物之谜，日用之繁，无处不用数学。”莫里斯·克菜园说：“数学是人类最高超的智力成就，也是人类心灵最独特的创作。音乐能激发或抚慰情怀，绘画使人赏心悦目，诗歌能扣人心弦，哲学使人获得智慧。科学可以改善物质生活，但数学却能提供以上的一切。”这就是数学独特的魅力所在。     

教育部有色及贵金属隐伏矿床勘查工程研究中心建设探索

针对有色及贵金属隐伏矿床勘查工程研究中心建设目标，对其建设进行探索研究。提出工程中心的建设应坚持研发特色，强化自主创新能力的提高；应以产-学-研基地建设为纽带，带动成果的工程转化与推广应用；应以灵活的人才流动体制与人才培养机制，以及科学的信息化项目管理与评价制度确保工程中心高效运行；应以多元化融资，改善中心软硬件环境，以此全面带动工程中心建设。     

井壁超热中子测井MC模拟

在 MCNP的基础上 ,开发了井壁超热中子时间谱测井蒙特卡罗 (Monte Carlo)模拟软件包 .裸眼井、井眼里无下井仪器、淡水饱和砂岩地层、井眼注淡水 ;油饱和砂岩地层、井眼注油 ;油饱和砂岩地层、井眼注淡水 ;淡水饱和灰岩地层、井眼注淡水与淡水饱和白云岩地层、井眼注淡水 ,及裸眼井、井眼里有下井仪器、淡水饱和砂岩地层、井眼注淡水等条件下 ,计算井壁超热中子时间谱随孔隙度的变化 ,同时可得到井壁超热中子总通量随孔隙度的变化 ,结果证明井壁超热中子时间谱测井或井壁超热中子测井是确定地层孔隙度最有效的方法 .在此基础上 ,再研究井壁超热中子时间谱测井仪或井壁超热中子测井仪的工程参数 .     

带观测器的模糊-线性复合控制

本文提出了带观测器的模糊-线性复合控制系统的一般结构形式,研究了模糊-Robust控制系统,文中用观测器来估计闭环系统的误差状态,将模糊控制器用于高阶系统的控制,拓广了现有模糊控制器的应用范围。