全文获取类型
收费全文 | 15635篇 |
免费 | 202篇 |
国内免费 | 381篇 |
专业分类
系统科学 | 377篇 |
丛书文集 | 949篇 |
教育与普及 | 671篇 |
理论与方法论 | 92篇 |
现状及发展 | 623篇 |
研究方法 | 1000篇 |
综合类 | 12501篇 |
自然研究 | 5篇 |
出版年
2023年 | 114篇 |
2022年 | 129篇 |
2021年 | 148篇 |
2020年 | 127篇 |
2019年 | 147篇 |
2018年 | 169篇 |
2017年 | 69篇 |
2016年 | 112篇 |
2015年 | 135篇 |
2014年 | 379篇 |
2013年 | 287篇 |
2012年 | 797篇 |
2011年 | 970篇 |
2010年 | 516篇 |
2009年 | 391篇 |
2008年 | 901篇 |
2007年 | 991篇 |
2006年 | 907篇 |
2005年 | 848篇 |
2004年 | 829篇 |
2003年 | 766篇 |
2002年 | 593篇 |
2001年 | 555篇 |
2000年 | 683篇 |
1999年 | 375篇 |
1998年 | 294篇 |
1997年 | 293篇 |
1996年 | 284篇 |
1995年 | 258篇 |
1994年 | 227篇 |
1993年 | 189篇 |
1992年 | 185篇 |
1991年 | 208篇 |
1990年 | 177篇 |
1989年 | 145篇 |
1988年 | 81篇 |
1987年 | 93篇 |
1986年 | 87篇 |
1985年 | 93篇 |
1984年 | 91篇 |
1983年 | 72篇 |
1982年 | 74篇 |
1981年 | 68篇 |
1980年 | 52篇 |
1959年 | 135篇 |
1958年 | 225篇 |
1957年 | 183篇 |
1956年 | 155篇 |
1955年 | 139篇 |
1954年 | 178篇 |
排序方式: 共有10000条查询结果,搜索用时 109 毫秒
981.
Dunham A Matthews LH Burton J Ashurst JL Howe KL Ashcroft KJ Beare DM Burford DC Hunt SE Griffiths-Jones S Jones MC Keenan SJ Oliver K Scott CE Ainscough R Almeida JP Ambrose KD Andrews DT Ashwell RI Babbage AK Bagguley CL Bailey J Bannerjee R Barlow KF Bates K Beasley H Bird CP Bray-Allen S Brown AJ Brown JY Burrill W Carder C Carter NP Chapman JC Clamp ME Clark SY Clarke G Clee CM Clegg SC Cobley V Collins JE Corby N Coville GJ Deloukas P Dhami P Dunham I Dunn M Earthrowl ME Ellington AG 《Nature》2004,428(6982):522-528
Chromosome 13 is the largest acrocentric human chromosome. It carries genes involved in cancer including the breast cancer type 2 (BRCA2) and retinoblastoma (RB1) genes, is frequently rearranged in B-cell chronic lymphocytic leukaemia, and contains the DAOA locus associated with bipolar disorder and schizophrenia. We describe completion and analysis of 95.5 megabases (Mb) of sequence from chromosome 13, which contains 633 genes and 296 pseudogenes. We estimate that more than 95.4% of the protein-coding genes of this chromosome have been identified, on the basis of comparison with other vertebrate genome sequences. Additionally, 105 putative non-coding RNA genes were found. Chromosome 13 has one of the lowest gene densities (6.5 genes per Mb) among human chromosomes, and contains a central region of 38 Mb where the gene density drops to only 3.1 genes per Mb. 相似文献
982.
983.
The electronic properties of many materials can be controlled by introducing appropriate impurities into the bulk crystal lattice in a process known as doping. In this way, diamond (a well-known insulator) can be transformed into a semiconductor, and recent progress in thin-film diamond synthesis has sparked interest in the potential applications of semiconducting diamond. However, the high dopant activation energies (in excess of 0.36 eV) and the limitation of donor incorporation to (111) growth facets only have hampered the development of diamond-based devices. Here we report a doping mechanism for diamond, using a method that does not require the introduction of foreign atoms into the diamond lattice. Instead, C60 molecules are evaporated onto the hydrogen-terminated diamond surface, where they induce a subsurface hole accumulation and a significant rise in two-dimensional conductivity. Our observations bear a resemblance to the so-called surface conductivity of diamond seen when hydrogenated diamond surfaces are exposed to air, and support an electrochemical model in which the reduction of hydrated protons in an aqueous surface layer gives rise to a hole accumulation layer. We expect that transfer doping by C60 will open a broad vista of possible semiconductor applications for diamond. 相似文献
984.
985.
The role of barren stalk1 in the architecture of maize 总被引:4,自引:0,他引:4
Gallavotti A Zhao Q Kyozuka J Meeley RB Ritter MK Doebley JF Pè ME Schmidt RJ 《Nature》2004,432(7017):630-635
The architecture of higher plants is established through the activity of lateral meristems--small groups of stem cells formed during vegetative and reproductive development. Lateral meristems generate branches and inflorescence structures, which define the overall form of a plant, and are largely responsible for the evolution of different plant architectures. Here, we report the isolation of the barren stalk1 gene, which encodes a non-canonical basic helix-loop-helix protein required for the initiation of all aerial lateral meristems in maize. barren stalk1 represents one of the earliest genes involved in the patterning of maize inflorescences, and, together with the teosinte branched1 gene, it regulates vegetative lateral meristem development. The architecture of maize has been a major target of selection for early agriculturalists and modern farmers, because it influences harvesting, breeding strategies and mechanization. By sampling nucleotide diversity in the barren stalk1 region, we show that two haplotypes entered the maize gene pool from its wild progenitor, teosinte, and that only one was incorporated throughout modern inbreds, suggesting that barren stalk1 was selected for agronomic purposes. 相似文献
986.
Hydrogenosomes are double-membraned ATP-producing and hydrogen-producing organelles of diverse anaerobic eukaryotes. In some versions of endosymbiotic theory they are suggested to be homologues of mitochondria, but alternative views suggest they arose from an anaerobic bacterium that was distinct from the mitochondrial endosymbiont. Here we show that the 51-kDa and 24-kDa subunits of the NADH dehydrogenase module in complex I, the first step in the mitochondrial respiratory chain, are active in hydrogenosomes of Trichomonas vaginalis. Like mitochondrial NADH dehydrogenase, the purified Trichomonas enzyme can reduce a variety of electron carriers including ubiquinone, but unlike the mitochondrial enzyme it can also reduce ferredoxin, the electron carrier used for hydrogen production. The presence of NADH dehydrogenase solves the long-standing conundrum of how hydrogenosomes regenerate NAD+ after malate oxidation. Phylogenetic analyses show that the Trichomonas 51-kDa homologue shares common ancestry with the mitochondrial enzyme. Recruitment of complex I subunits into a H2-producing pathway provides evidence that mitochondria and hydrogenosomes are aerobic and anaerobic homologues of the same endosymbiotically derived organelle. 相似文献
987.
Evidence for cultivar adoption and emerging complexity during the mid-Holocene in the La Plata basin
Iriarte J Holst I Marozzi O Listopad C Alonso E Rinderknecht A Montaña J 《Nature》2004,432(7017):614-617
Multidisciplinary investigations at the Los Ajos archaeological mound complex in the wetlands of southeastern Uruguay challenge the traditional view that the La Plata basin was inhabited by simple groups of hunters and gatherers for much of the pre-Hispanic era. Here we report new archaeological, palaeoecological and botanical data indicating that during an increasingly drier mid-Holocene, at around 4,190 radiocarbon (14C) years before present (bp), Los Ajos became a permanent circular plaza village, and its inhabitants adopted the earliest cultivars known in southern South America. The architectural plan of Los Ajos during the following Ceramic Mound Period (around 3,000-500 14C yr bp) is similar to, but earlier than, settlement patterns demonstrated in Amazonia, revealing a new and independent architectural tradition for South America. 相似文献
988.
989.
Mechelli A Crinion JT Noppeney U O'Doherty J Ashburner J Frackowiak RS Price CJ 《Nature》2004,431(7010):757
Humans have a unique ability to learn more than one language--a skill that is thought to be mediated by functional (rather than structural) plastic changes in the brain. Here we show that learning a second language increases the density of grey matter in the left inferior parietal cortex and that the degree of structural reorganization in this region is modulated by the proficiency attained and the age at acquisition. This relation between grey-matter density and performance may represent a general principle of brain organization. 相似文献
990.