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121.
Kévin Baranger Yannick Marchalant Amandine E. Bonnet Nadine Crouzin Alex Carrete Jean-Michel Paumier Nathalie A. Py Anne Bernard Charlotte Bauer Eliane Charrat Katrin Moschke Mothoharu Seiki Michel Vignes Stefan F. Lichtenthaler Frédéric Checler Michel Khrestchatisky Santiago Rivera 《Cellular and molecular life sciences : CMLS》2016,73(1):217-236
122.
Antipredatory defense of pronghorn ( Antilocapra americana ) neonates (≤1 month old) by adult females (>18 months old) is well documented throughout the geographic range of this species. However, reports of male pronghorn defending neonates against predators are limited to a single study in northwestern Wyoming where occurrences were documented of adult males assisting female pronghorn in defending neonates against coyotes ( Canis latrans ). To our knowledge, defense of neonatal pronghorn by yearling males (12–18 months old) has not been reported previously for this species. We report occurrences of antipredatory defense of neonatal pronghorn by yearling males in southwestern South Dakota. La defensa antidepredadora de los neonatos (≤30 días de edad) del berrendo ( Antilocapra americana ) por hembras adultas (>18 meses de edad) está bien documentada en toda la distribución geográfica de esta especie. Sin embargo, no se había reportado la defensa de neonatos contra depredadores por parte de berrendos machos con excepción de un solo estudio en el noroeste de Wyoming, donde documentaron algunos casos en los que machos adultos ayudaron a los berrendos hembras a defender los neonatos contra coyotes ( Canis latrans ). Hasta donde sabemos, la defensa de berrendos neonatales por machos de alrededor de un año de edad (de 12–18 meses de edad) no se había reportado previamente. Reportamos casos de defensa antidepredadora de berrendos neonatales por parte de machos de un año de edad en el suroeste de Dakota del Sur. 相似文献
123.
Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause DNA damage. Ethanol, which is metabolised to acetaldehyde, is both carcinogenic and teratogenic in humans. Here we find that the Fanconi anaemia DNA repair pathway counteracts acetaldehyde-induced genotoxicity in mice. Our results show that the acetaldehyde-catabolising enzyme Aldh2 is essential for the development of Fancd2(-/-) embryos. Nevertheless, acetaldehyde-catabolism-competent mothers (Aldh2(+/-)) can support the development of double-mutant (Aldh2(-/-)Fancd2(-/-)) mice. However, these embryos are unusually sensitive to ethanol exposure in utero, and ethanol consumption by postnatal double-deficient mice rapidly precipitates bone marrow failure. Lastly, Aldh2(-/-)Fancd2(-/-) mice spontaneously develop acute leukaemia. Acetaldehyde-mediated DNA damage may critically contribute to the genesis of fetal alcohol syndrome in fetuses, as well as to abnormal development, haematopoietic failure and cancer predisposition in Fanconi anaemia patients. 相似文献
124.
Pryor WR Rymer AM Mitchell DG Hill TW Young DT Saur J Jones GH Jacobsen S Cowley SW Mauk BH Coates AJ Gustin J Grodent D Gérard JC Lamy L Nichols JD Krimigis SM Esposito LW Dougherty MK Jouchoux AJ Stewart AI McClintock WE Holsclaw GM Ajello JM Colwell JE Hendrix AR Crary FJ Clarke JT Zhou X 《Nature》2011,472(7343):331-333
Although there are substantial differences between the magnetospheres of Jupiter and Saturn, it has been suggested that cryovolcanic activity at Enceladus could lead to electrodynamic coupling between Enceladus and Saturn like that which links Jupiter with Io, Europa and Ganymede. Powerful field-aligned electron beams associated with the Io-Jupiter coupling, for example, create an auroral footprint in Jupiter's ionosphere. Auroral ultraviolet emission associated with Enceladus-Saturn coupling is anticipated to be just a few tenths of a kilorayleigh (ref. 12), about an order of magnitude dimmer than Io's footprint and below the observable threshold, consistent with its non-detection. Here we report the detection of magnetic-field-aligned ion and electron beams (offset several moon radii downstream from Enceladus) with sufficient power to stimulate detectable aurora, and the subsequent discovery of Enceladus-associated aurora in a few per cent of the scans of the moon's footprint. The footprint varies in emission magnitude more than can plausibly be explained by changes in magnetospheric parameters--and as such is probably indicative of variable plume activity. 相似文献
125.
Hartogh P Lis DC Bockelée-Morvan D de Val-Borro M Biver N Küppers M Emprechtinger M Bergin EA Crovisier J Rengel M Moreno R Szutowicz S Blake GA 《Nature》2011,478(7368):218-220
For decades, the source of Earth's volatiles, especially water with a deuterium-to-hydrogen ratio (D/H) of (1.558?±?0.001)?×?10(-4), has been a subject of debate. The similarity of Earth's bulk composition to that of meteorites known as enstatite chondrites suggests a dry proto-Earth with subsequent delivery of volatiles by local accretion or impacts of asteroids or comets. Previous measurements in six comets from the Oort cloud yielded a mean D/H ratio of (2.96?±?0.25)?×?10(-4). The D/H value in carbonaceous chondrites, (1.4?±?0.1)?×?10(-4), together with dynamical simulations, led to models in which asteroids were the main source of Earth's water, with ≤10 per cent being delivered by comets. Here we report that the D/H ratio in the Jupiter-family comet 103P/Hartley 2, which originated in the Kuiper belt, is (1.61?±?0.24)?×?10(-4). This result substantially expands the reservoir of Earth ocean-like water to include some comets, and is consistent with the emerging picture of a complex dynamical evolution of the early Solar System. 相似文献
126.
127.
128.
Summary Diameters of mitochondria of the external zona fasciculata of the adrenal cortex of 4 female and 4 male Sprague-Dawley-rats are determined with the image analyzing computer Quantimet 720. On the average females have significantly larger mitochondria. The mitochondria show an ellipsoid deformation, the long axes are orientated parallel to the columns of the zona fasciculata. 相似文献
129.
Summary Valium® anaesthesia significantly reduces the effect of large single doses of X-rays on the mouse foot skin as compared with Nembutal® anaesthesia. The radioprotective action of Valium may be attributed to a direct effect on the cells of the skin.Supported by the Swiss National Science Foundation (Grant no. 3.682-0.75).Acknowledgments. The authors wish to thank Miss F.T. Josuran, Miss U. Schärer and Mr P.P. Binz for their excellent technical assistance with the experiments. 相似文献
130.
Bowler C Allen AE Badger JH Grimwood J Jabbari K Kuo A Maheswari U Martens C Maumus F Otillar RP Rayko E Salamov A Vandepoele K Beszteri B Gruber A Heijde M Katinka M Mock T Valentin K Verret F Berges JA Brownlee C Cadoret JP Chiovitti A Choi CJ Coesel S De Martino A Detter JC Durkin C Falciatore A Fournet J Haruta M Huysman MJ Jenkins BD Jiroutova K Jorgensen RE Joubert Y Kaplan A Kröger N Kroth PG La Roche J Lindquist E Lommer M Martin-Jézéquel V Lopez PJ Lucas S Mangogna M McGinnis K 《Nature》2008,456(7219):239-244
Diatoms are photosynthetic secondary endosymbionts found throughout marine and freshwater environments, and are believed to be responsible for around one-fifth of the primary productivity on Earth. The genome sequence of the marine centric diatom Thalassiosira pseudonana was recently reported, revealing a wealth of information about diatom biology. Here we report the complete genome sequence of the pennate diatom Phaeodactylum tricornutum and compare it with that of T. pseudonana to clarify evolutionary origins, functional significance and ubiquity of these features throughout diatoms. In spite of the fact that the pennate and centric lineages have only been diverging for 90 million years, their genome structures are dramatically different and a substantial fraction of genes ( approximately 40%) are not shared by these representatives of the two lineages. Analysis of molecular divergence compared with yeasts and metazoans reveals rapid rates of gene diversification in diatoms. Contributing factors include selective gene family expansions, differential losses and gains of genes and introns, and differential mobilization of transposable elements. Most significantly, we document the presence of hundreds of genes from bacteria. More than 300 of these gene transfers are found in both diatoms, attesting to their ancient origins, and many are likely to provide novel possibilities for metabolite management and for perception of environmental signals. These findings go a long way towards explaining the incredible diversity and success of the diatoms in contemporary oceans. 相似文献