Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans

Identification of the genes underlying complex phenotypes and the definition of the evolutionary forces that have shaped eukaryotic genomes are among the current challenges in molecular genetics. Variation in gene copy number is increasingly recognized as a source of inter-individual differences in genome sequence and has been proposed as a driving force for genome evolution and phenotypic variation. Here we show that copy number variation of the orthologous rat and human Fcgr3 genes is a determinant of susceptibility to immunologically mediated glomerulonephritis. Positional cloning identified loss of the newly described, rat-specific Fcgr3 paralogue, Fcgr3-related sequence (Fcgr3-rs), as a determinant of macrophage overactivity and glomerulonephritis in Wistar Kyoto rats. In humans, low copy number of FCGR3B, an orthologue of rat Fcgr3, was associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus. The finding that gene copy number polymorphism predisposes to immunologically mediated renal disease in two mammalian species provides direct evidence for the importance of genome plasticity in the evolution of genetically complex phenotypes, including susceptibility to common human disease.     

智能控制系统智能水平评价的软件系统

在“一种智能控制系统智能水平的评价方法”提出方法的基础上,提出一种新的评价算法,并设计开发出智能控制系统智能水平评价的软件系统。给出了系统的功能模块设计、数据库设计等,最后列举了两个模拟评价的例子。     

集料粒径与体积分数对水稳碎石材料抗裂性能的影响

为了研究集料粒径和体积分数对水稳碎石材料抗裂性能的影响,借助离散元法构建了具有相同集料轮廓与位置、不同集料粒径与含量的圆形劈裂数值试件.通过虚拟间接拉伸试验模拟了水稳碎石细观开裂过程,并进一步研究了集料粒径与体积分数对结构细观开裂行为的影响.结果 表明:集料粒径和体积分数对数值试件的力学性能有着显著影响,降低集料体积分...     

铁路运输动态车流组织的策略优化模型研究

基于我国铁路网络规模大、列车组织形式多样化以及按图行车的特点,设计了与物理时空网络有所区别的服务时空网络.时空网是研究铁路动态车流组织的一种有效方法.借助于服务时空网,构建了我国铁路运输动态车流组织的策略优化模型,该模型将重空车运输联合考虑,并兼顾站点装卸能力、解编能力、输送能力以及政策性运输任务等对优化目标的影响.基于模型的特点,设计了能解决大规模网络问题的基于整数编码的改进遗传算法.最后以实例显示了该算法的有效性.     

计算机联锁系统的通信可靠性研究

分析了计算机联锁系统中存在的3部分通信及其对联锁系统的不同影响,描述了通过相互隔离的网络结构,避免不同通信间的相互干扰以提高通信的可靠性,并具体阐述了通过容错技术、软件处理提高联锁系统内部通信的可靠性.     

南宁市酸雨影响因素分析

根据南宁市环保监测站的酸雨监测资料和南宁市气象局的气象观测资料,分析南宁市本地污染源排放、大气颗粒物缓冲能力、大气中H2O2含量以及气象因素对南宁市酸雨的影响,提出南宁市的自然地理环境和气象气候条件有利于酸雨的形成,其形成与冷空气关系密切;影响南宁市的大气环流主要是东路、中路冷空气,这两股冷空气南下时容易形成酸雨且降水酸性明显增强。南宁市的酸雨受外来的影响非常明显。     

Fair Resource Allocation in Networks with Coexisting Unicast and Multirate Multicast Flows

To maximize the aggregate user utility in networks with both multirate multicast and unicast traffic, a unified convex program formulation of the problem is used to integrate multicast and unicast sessions into a common framework, which also takes into account the heterogeneity of multicast receivers. By applying a penalty function approach, a heuristic rate control algorithm is derived. In the distributed implementation of the algorithm in IP networks, core routers employ Random Early Detection (RED) to mark packets in the case of congestion; end-users analyze congestion feedback information and update their rates to calculated optimal values. With an appropriate choice of utility functions and parameters, multicast and unicast sessions can share network resources in the proportional fair manner. Simulation results prove the algorithm‘ s effectiveness. Study is also done on the effect of bandwidth discretization density upon resource allocation fairness in a layered multicast scenario.     

生物技术改良膨胀土探讨

将生物技术引入膨胀土改良问题中．根据不同类型的膨胀土筛选出生命力强、能消除或显著减弱土的胀缩性．且能促进自然生态环境良性发展的菌种．通过调查发现可以利用某些微生物的助滤、疏水作用或改变粘土矿物表而电荷电性的特性,削减结合水膜的厚度。提高膨胀土的抗剪强度．     

高新技术产品人-机系统的模糊综合评价法

通过对高新技术产品人一机系统的全面分析,建立了其系统的模糊综合评判的指标体系,给出了模糊系统评价模型和模糊评价方法,介绍了运用择优比较法确定权重的方法,并进行了实例分析。     

酸碱改性活性炭吸附水中乙酰水杨酸的行为与机理

采用硝酸(HNO_3)和氢氧化钠(Na OH)对活性炭表面进行改性,并考察其对乙酰水杨酸(ASP)的吸附性能。借助傅里叶红外光谱(FTIR)和扫描电镜(SEM)对改性活性炭结构特性进行表征,考察孔隙结构和官能团与吸附性能的关系,推断改性活性炭中对ASP起主要作用的官能团是含氧官能团。结果表明,两种改性活性炭对ASP均有良好的吸附效果;与Freundlich方程相比,吸附过程更适合用Langmuir方程来进行描述;也表明了活性炭对ASP的吸附属于单分子层吸附。改性后活性炭的最大吸附量可达到96.129 8 mg/g,且吸附过程更符合二级动力学方程。