基于收益-风险模型分析高校学生在线健康咨询服务使用意愿的影响因素

目的:研究高校学生在线健康咨询服务使用意愿的影响因素.方法:采用方便抽样,使用"问卷星"设计和制作调查问卷,并对成都市两所大学的500名大学生进行问卷调查,使用结构方程模型对在线健康咨询服务使用意愿的影响因素进行分析.结果:问卷回收443份,回收率为88.40%,有效442份,有效率为99.77%.感知收益(β=0.368,P0.001)、网络信任(β=0.147,P0.05)和医生信任(β=0.129,P0.05)正向影响使用意愿;感知风险(β=-0.018,P0.05)、平台信任(β=0.141,P0.05)对使用意愿的直接影响未得到支持;网络信任和医生信任在感知风险与使用意愿的关系间具有完全中介作用,在感知收益与使用意愿的关系间发挥部分中介作用.结论:增加公众对网络环境和网上医生的信任以及提高患者潜在的利益是提高在线健康咨询服务的使用意愿的关键.     

Trends in A8 migration to the UK during the recession

A substantial proportion of contemporary migration flows to the UK are made by nationals from countries which have recently joined the EU. The nature of A8 migration during the recession is examined in this paper, mainly using data from the Worker Registration Scheme. The recession has seen a decline in new A8 migrants entering the UK labour market, but the decline has been sectorally uneven, with demand for migrant labour being most persistent in the agricultural sector, raising questions about why this part of the UK economy is so different.     

广义Γ分布的Pearson-x2距离及其渐近性

利用Pearson-x2距离和最大距离的定义,首次探讨了广义Γ分布的Pearson-x2距离及其渐近性,并作为特例得到了Γ分布、Weibull分布、指数分布的Pearson-x2距离及其渐近性.     

Short Report： Cyclic patterns of incidence rate for skin malignant melanoma： association with heliogeophysical activity

Background： Our previous studies revealed cyclicity in the incidence rate of skin malignant melanoma （SMM; ICD9, Dx： 172） in the Czech Republic （period T=7.50～7.63 years）, UK （T= 11.00 years） and Bulgaria （T= 12.20 years）. Incidences com- pared with the sunspot index Rz （lag-period dT=＋2, ＋4, ＋6, ＋ 10 or ＋ 12 years） have indicated that maximal rates are most likely to appear on descending slopes of the ;ll-year solar cycle, i.e., out of phase. We summarized and explored more deeply these cyclic variations and discussed their possible associations with heliogeophysical activity （HGA） components exhibiting similar cyclicity. Methods： Annual incidences of SMM from 5 countries （Czech Republic, UK, Bulgaria, USA and Canada） over various time spans during the years 1964-1992 were analyzed and their correlations with cyclic Rz （sunspot number） and aa （planetary geomagnetic activity） indices were summarized. Periodogram regression analysis with trigonometric approximation and phase-correlation analysis were applied. Results： Previous findings on SMM for the Czech Republic, UK and Bulgaria have been validated, and cyclic patterns have been revealed for USA （T=8.63 years, P〈0.05） and Canada （Ontario, T=9.91 years, P〈0.10）. Also, various ＇hypercycles＇ were established （T=45.5, 42.0, 48.25, 34.5 and 26.5 years, respectively） describing long-term cyclic incidence patterns. The association of SMM for USA and Canada with Rz （dT=＋6 and ＋7 years, respectively） and aa （dT=-10 and ＋9 years, respectively） was described. Possible interactions of cyclic non-photic influences （UV irradiation, Schumann resonance signal, low-frequency geomagnetic fluctuations） with brain waves absorbance, neuronal calcium dynamics, neuro-endocrine axis modulation, melatonin/serotonin disbalance and skin neuro-immunity impairment as likely causal pathways in melanoma appearance, were also discussed. Conclusion： The above findings on cyclicity and temporal assoc     

逆高斯分布的Pearson-x2距离及其渐近性

利用Pearson-x2最大距离的定义,讨论了逆高斯分布的Pearson-x2最大距离及其渐近性.     

大学物理网络教学平台设计与实践

应用ASP脚本语言作为开发环境,选择3DS MAX动画制作软件、Photoshop图形编辑软件、Word 2000文档编辑软件及Access 2000数据库编辑软件制作了<大学物理>网络教学系统.这是一个集成了在线学习交流、专题讨论、作业系统、资料上传与下载、在线测试等功能为一体的、交互式的、动态的可视化网络教学系统.该系统是为促进大学物理学习而开发的,它既可以作为教学之用,同时也可以作为相关专业人员自学和专业培训使用.     

混合有限元，相容性条件及应用

本书是斯普林格出版公司的系列丛书《数学讲座》的第1939卷,汇集了2006年6月26日～7月1日在意大利Cetraro举办的与本书同名的C．I．M．E夏季学校的讲稿。早在上世纪70年代,混合有限元就已成为数学和工程界广泛深入的研究课题,这个方法对于许多应用领域的基础性作用获得全球范围的公认,并被引进若干商用编码中。由于理论与应用间的相互影响,使该领域的发展前景更为令人注目。一方面,许多实际应用模式已被置于严格的数学框架中;另一方面,     

字宙和原子

这是一部高级科普读物,作者是一位著名的粒子物理理论家。在本书中,他深入浅出地对于最大的和最小的世界,从做为整体的宇宙到人类无法直接感知的亚原子物理学给出了简明扼要的介绍。内容涉及到了宇宙学、天体物理学、牛顿力学、量子力学、相对论、原子物理学、核物理学、基本粒子物理学直至大爆炸、元素合成和暗物质与暗能量,     

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

Copper is a cofactor for many cellular enzymes and transporters. It can be loaded onto secreted and endomembrane cuproproteins by translocation from the cytosol into membrane-bound organelles by ATP7A or ATP7B transporters, the genes for which are mutated in the copper imbalance syndromes Menkes disease and Wilson disease, respectively. Endomembrane cuproproteins are thought to incorporate copper stably on transit through the trans-Golgi network, in which ATP7A accumulates by dynamic cycling through early endocytic compartments. Here we show that the pigment-cell-specific cuproenzyme tyrosinase acquires copper only transiently and inefficiently within the trans-Golgi network of mouse melanocytes. To catalyse melanin synthesis, tyrosinase is subsequently reloaded with copper within specialized organelles called melanosomes. Copper is supplied to melanosomes by ATP7A, a cohort of which localizes to melanosomes in a biogenesis of lysosome-related organelles complex-1 (BLOC-1)-dependent manner. These results indicate that cell-type-specific localization of a metal transporter is required to sustain metallation of an endomembrane cuproenzyme, providing a mechanism for exquisite spatial control of metalloenzyme activity. Moreover, because BLOC-1 subunits are mutated in subtypes of the genetic disease Hermansky-Pudlak syndrome, these results also show that defects in copper transporter localization contribute to hypopigmentation, and hence perhaps other systemic defects, in Hermansky-Pudlak syndrome.