Small myelinated perikarya in the cerebellar granular layer of mammals including man

Zusammenfassung Kleinzellen mit perikarieller Markscheide wurden in der Körnerschicht des Kleinhirns verschiedener Säuger und des Menschen gefunden. Diese Zellen treten bei der Maus erst am 8. Tag nach der Geburt auf und wurden nur in der Körnerschicht, offenbar als Körnerzellen, beobachtet.     

Starvation and gastrin storage in the pyloric antral mucosa of male rabbits

Résumé Parmi les lapins mâles privés de nourriture pendant une période de 72 h au maximum, la quantité de gastrine brutte par gramme fut la plus élevée chez les sujets soumis à ce test pendant 12 h et la moins élevée chez ceux qui l'ont subit pendant 72 h au maximum. L'activité gastrique de l'extrait brut n'était pas affectée par la privation de nourriture et aucune corrélation ne put être établie entre le taux de la glucose sanguine et la gastrine accumulée chez les lapins affamés.

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Acknowledgments. I am grateful to the M. R. C. London for the synthetic human gastrin I used. This work was supported by fund from University of Ibadan Senate Research Grant.     

Studies on the quaternary structure of the first enzyme for histidine biosynthesis

Resumen Se han realizado estudios de asociación-disociación por filtración en gel con el primer enzima de la biosíntesis de histidina enEscherichia coli, en presencia de sustratos y ligandos. Se observa una interconversión reversible entre las formas dímero, tetrámero y exámero, y una agregación irreversible de orden superior.     

The properties of neuraminidase-treated crystalline ceruloplasmin

Résumé On sait que la plasmine céruléenne crystalline rétroplacentaire humaine ainsi qua la plasmine apocérulécnne empêchent l'hémaglutination virale. Cet effet pourrait être attribué aux résidus d'acide sialique, car l'action préventive disparaît après traitement de la plasmine céruléenne par la neuraminidase.     

An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice

Inflammation influences iron balance in the whole organism. A common clinical manifestation of these changes is anemia of chronic disease (ACD; also called anemia of inflammation). Inflammation reduces duodenal iron absorption and increases macrophage iron retention, resulting in low serum iron concentrations (hyposideremia). Despite the protection hyposideremia provides against proliferating microorganisms, this 'iron withholding' reduces the iron available to maturing red blood cells and eventually contributes to the development of anemia. Hepcidin antimicrobial peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption and macrophage iron release. Hamp is part of the type II acute phase response and is thought to have a crucial regulatory role in sequestering iron in the context of ACD. Mice with deficiencies in the hemochromatosis gene product, Hfe, mounted a general inflammatory response after injection of lipopolysaccharide but lacked appropriate Hamp expression and did not develop hyposideremia. These data suggest a previously unidentified role for Hfe in innate immunity and ACD.     

The knockout mouse project

Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.