基于CFD的液压滑阀多学科优化设计

为了降低滑阀开启和关闭过程中瞬态液动力的影响,提高液压滑阀换向稳定性和可靠性,以典型的三位四通换向滑阀为对象,利用计算流体动力学方法(CFD)对滑阀开启过程进行了动态模拟,可视化地解析了流道结构参数对瞬态液动力的影响.针对滑阀阀芯、阀座沉槽、阀芯间流道结构,建立了参数化模型,借助于CFD解析、试验设计、近似模型技术,对滑阀动态解析过程进行了一体化集成,并以二阶响应面函数的形式表达了开启瞬间瞬态液动力与流道结构参数之间的响应面模型.最后,对流道结构参数进行了优化设计,为提高滑阀性能提供了定量化再设计依据.     

复合式缆索吊机在落布溪大桥钢管拱肋吊装施工中的应用

文章详细介绍了复合式缆索吊机在落布溪大桥拱肋吊装中的应用,并简单介绍了线形控制的原理和方法.     

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), MDS/MPN overlap syndromes including chronic myelomonocytic leukaemia (CMML), acute myeloid leukaemias (AML) and secondary AML (sAML). We show here that TET2 mutations associated with myeloid malignancies compromise catalytic activity. Bone marrow samples from patients with TET2 mutations displayed uniformly low levels of 5hmC in genomic DNA compared to bone marrow samples from healthy controls. Moreover, small hairpin RNA (shRNA)-mediated depletion of Tet2 in mouse haematopoietic precursors skewed their differentiation towards monocyte/macrophage lineages in culture. There was no significant difference in DNA methylation between bone marrow samples from patients with high 5hmC versus healthy controls, but samples from patients with low 5hmC showed hypomethylation relative to controls at the majority of differentially methylated CpG sites. Our results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis. Measurement of 5hmC levels in myeloid malignancies may prove valuable as a diagnostic and prognostic tool, to tailor therapies and assess responses to anticancer drugs.     

容县基本农田划定与保护研究

摘要：分析了广西容县土地利用情况,包括耕地现状以及上级下达的土地利用总体规划确定的基本农田,划定前的基本农田的数量情况、质量情况和分布情况,划出划人情况,其中划出的基本农田包括不可调整的农用地、建设用地、坡度大于25°的耕地、不稳定耕地、土规预留范围内农保、零散分布图斑、零星达不到上图面积的村庄。     

Corrosion inhibition of stainless steel by a sulfate-reducing bacteria biofilm in seawater

Corrosion inhibition of stainless steel due to a sulfate-reducing bacteria (SRB) biofilm in seawater was studied. By atomic force microscopy, a layer of fish-scale-like biofilm was found to form as stainless steel coupons were exposed to the culture media with SRB, and this biofilm grew more and more compact. As a result, coupons' surface under the biofilm turned irregular less slowly than that exposed to the sterilized culture media. Then, physicoelectric characteristics of the electrode/biofilm/solution interface were investigated by electrochemical impedance spectroscopy (EIS), and the coverage of the biofilm as well as the relative irregularity of coupons' surface was also recorded by EIS spectra. Finally, anodic cyclic polarization results further demonstrated the protective property of the biofilm. Therefore, in estimation of SRB-implicated corrosion of stainless steel, not only the detrimental SRB metabolites but also the protective SRB biofilm as well should be taken into account.     

基于SEIR模型视角的重大公共卫生事件中伪科学网络谣言的传播治理：以新冠肺炎疫情为例

 新型冠状病毒肺炎防疫工作进入关键时期,而期间大量滋生的伪科学网络谣言导致各地广泛出现盲目抢购、囤货等不良社会事件,严重影响疫情防控与社会正常秩序。以新冠肺炎疫情为例,在总结梳理国内外学者对伪科学、网络谣言等定义的基础上,给出适用本文的伪科学网络谣言的定义;选取本次疫情中影响较大的4个伪科学网络谣言,收集其在新浪微博传播过程中的数据,分析伪科学网络谣言在疫情中的传播特点;以SEIR模型为基础,综合考虑政府干预滞后性、个体信息接受从众效应、谣言传播特点等对模型进行合理改进,并通过数值实验对重大公共卫生事件中的伪科学网络谣言传播机制进一步研究;最后,基于前文分析从不同角度对重大公共卫生事件中伪科学网络谣言的传播治理提出针对性对策建议。     

基于遗传算法的室内装饰材料色彩合理搭配方法

为了解决传统方法计算过程极为复杂对专业知识的采集信息不完整,无法覆盖整个色彩搭配领域,无唯一最优解的弊端,通过遗传算法研究了室内装饰材料色彩合理搭配方法。通过三维部件与色彩构成遗传算法中染色体进行遗传编码。将RGB转变成HSL,计算色彩不和谐系数,充分分析了室内装饰材料色彩搭配时的调和度,求出视觉舒适度。通过色彩搭配和谐度、色彩搭配调和度和视觉舒适度三部分加权组成室内装饰材料色彩搭配适应度函数。利用遗传算法的选择、交叉和变异操作获取适应度最高的个体,设置停止迭代条件,得到室内装饰材料色彩合理搭配结果。结果表明:所提方法色彩搭配结果有更好的色彩舒适性;通过色彩搭配结果评价调查发现,大部分顾客对采用所提方法得到的室内装饰材料色彩搭配方案的评价结果为非常满意或满意,方法操作简单。可见所提方法搭配色彩合理,性能优越。     

铜阳极泥碱性加压氧化浸出渣的硫酸浸出过程

针对铜阳极泥碱性加压氧化浸出渣开展硫酸浸出过程研究,考察硫酸浓度、温度、时间、液固比、搅拌速度和氧化方式等因素对浸出渣渣率和金属浸出率的影响.研究结果表明:金属浸出率随硫酸浓度的增加而提高,银的溶解尤为明显;硫酸浸出渣中未溶解的铜主要以单质存在,采用空气氧化方式可以提高铜的浸出率;在最佳条件即硫酸浓度为2.7 mol/L,温度为85℃,液固比为5∶1,时间为2h,空气压力为0.1～0.2 MPa和搅拌速度为300 r/min下,硫酸浸出渣率为60.0％,Cu和Te的浸出率分别为97.65％和77.53％,Ag和Sb的浸出率分别为8.95％和2.0％.     

FIDIC施工合同条件下变更与索赔的比较研究

变更和索赔是国际工程中经常出现的现象,也是国内外工程合同管理的重点和难点,处理上容易造成混淆．通过分析FIDIC施工合同条件下变更与索赔在定义、范围、性质、原因、处理原则、计价支付、处理程序上的区别以及两者的联系,系统研究了两者的关系,提出承发包双方在合同处理上既要区别又要善于把握联系．