对我国体育双语教学科研状况的探讨

双语教学是当前学校教学改革的重要举措之一,体育课程又是学校教学的重要组成部分,所以理应去适应学校教学改革和发展,本文对学校体育实施双语教学的科研现状进行了分析,指出当前体育双语教学科研存在的问题和不足,以求促进我国体育双语教学科研整体水平的不断提高.     

兰州石化AEB型催化剂在液相分子筛制乙苯中的工业化应用

回顾了工业制乙苯发展历程,分析了苯和乙烯液相法制乙苯的反应机理;利用催化剂机理并结合生产实践,得出了液相分子筛制乙苯催化剂的影响因素和保养方法。     

刷式密封迟滞特性的数值研究

采用非线性接触模型对刷式密封的迟滞特性及其影响因素进行了研究.采用点-面接触、梁-梁相交接触和梁-梁平行接触模拟了刷式密封中刷丝端部与转子表面接触、刷丝与背板边缘接触以及刷丝之间的接触,建立了刷式密封的非线性接触模型,并通过试验研究的刷式密封迟滞特性的数据验证了所建立模型的有效性.研究分析了刷丝径向刚度一定时,刷丝直径、刷丝长度和刷丝角度对刷式密封迟滞特性的影响规律,结果表明,刷丝端部压力计算值与理论值的比值可以更好地评定刷式密封迟滞特性的强弱.当刷丝直径保持不变时,随着刷丝角度的增加和刷丝长度的减小,刷式密封的迟滞特性越来越弱;当刷丝长度一定时,随着刷丝角度和刷丝直径的增加,刷丝的迟滞特性越来越弱;当刷丝角度一定时,不同刷丝直径和刷丝长度的刷式密封表现出相近的迟滞特性;当刷丝径向刚度一定时,刷式密封的迟滞特性强弱主要由刷丝角度决定.     

钢管拱横撑管单面焊双面成型工艺研究

文章重点阐述了京沪高铁柳泉镇后八丁特大桥钢管拱横撑管单面焊双面成型焊接工艺,根据结构特点和设计要求,从单面焊双面成型焊接的主要施工特点和难点、焊接方法、工艺的对比以及单面焊双面成型焊接存在的问题、采取的工艺措施以及单面焊双面成型的焊接工艺进行了详细的分析、研究,改善了外观成型,提高了生产效率,对确保钢管拱桥横撑管的焊接质量和外形尺寸精度,提高工效,缩短工期,降低制造成本有着重要的意义。     

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

Infections by the Ebola and Marburg filoviruses cause a rapidly fatal haemorrhagic fever in humans for which no approved antivirals are available. Filovirus entry is mediated by the viral spike glycoprotein (GP), which attaches viral particles to the cell surface, delivers them to endosomes and catalyses fusion between viral and endosomal membranes. Additional host factors in the endosomal compartment are probably required for viral membrane fusion; however, despite considerable efforts, these critical host factors have defied molecular identification. Here we describe a genome-wide haploid genetic screen in human cells to identify host factors required for Ebola virus entry. Our screen uncovered 67 mutations disrupting all six members of the homotypic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, which is involved in the fusion of endosomes to lysosomes, and 39 independent mutations that disrupt the endo/lysosomal cholesterol transporter protein Niemann-Pick C1 (NPC1). Cells defective for the HOPS complex or NPC1 function, including primary fibroblasts derived from human Niemann-Pick type C1 disease patients, are resistant to infection by Ebola virus and Marburg virus, but remain fully susceptible to a suite of unrelated viruses. We show that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport. Our findings uncover unique features of the entry pathway used by filoviruses and indicate potential antiviral strategies to combat these deadly agents.     

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Editing of the human genome to correct disease-causing mutations is a promising approach for the treatment of genetic disorders. Genome editing improves on simple gene-replacement strategies by effecting in situ correction of a mutant gene, thus restoring normal gene function under the control of endogenous regulatory elements and reducing risks associated with random insertion into the genome. Gene-specific targeting has historically been limited to mouse embryonic stem cells. The development of zinc finger nucleases (ZFNs) has permitted efficient genome editing in transformed and primary cells that were previously thought to be intractable to such genetic manipulation. In vitro, ZFNs have been shown to promote efficient genome editing via homology-directed repair by inducing a site-specific double-strand break (DSB) at a target locus, but it is unclear whether ZFNs can induce DSBs and stimulate genome editing at a clinically meaningful level in vivo. Here we show that ZFNs are able to induce DSBs efficiently when delivered directly to mouse liver and that, when co-delivered with an appropriately designed gene-targeting vector, they can stimulate gene replacement through both homology-directed and homology-independent targeted gene insertion at the ZFN-specified locus. The level of gene targeting achieved was sufficient to correct the prolonged clotting times in a mouse model of haemophilia B, and remained persistent after induced liver regeneration. Thus, ZFN-driven gene correction can be achieved in vivo, raising the possibility of genome editing as a viable strategy for the treatment of genetic disease.     

一种分类机械手的研制与开发

提出了一种用在晶体角分类机上替代工人来完成卸料及分类工作的机械手.该分类机械手是机械、电气传动、气动控制、嵌入式微控制器和微电子器件相结合的产物.机械部分构成了分类机械手的骨架;步进电机等使分类机械手实现了准确运动;气动元件使分类机械手变得灵巧、简捷.借助于系统状态变换等方法,以微控制器C8051F206为核心的分类机械手控制器的软件给予了分类机械手某些简单的人工智能,使其能准确无误地重复完成卸料及分类任务.分类机械手的基准定位与步进电机步进计数控制的结合可使其长期运行无积累误差.经在工业现场的长期使用证明,该分类机械手设计合理、工作可靠.     

K2NaH[Cr3O(OOCCH3)6(H2O)3][α-CoW12O40]·10H2O离子晶体的合成与晶体结构

合成了K2NaH[Cr3O(OOCCH3)6(H2O)3][α-CoW12O40].10H2O离子晶体,并用X射线单晶衍射、元素分析、红外光谱和固体漫反射电子光谱对晶体的结构进行了表征.该晶体属于单斜晶系;C2/c空间群,a=4.190 5(8)nm,b=1.615 8(3)nm,c=2.983 4(6)nm,β=123.67(3)°,V=16.812(6)nm3,Z=14,F(000)=13 200,R1=0.076 3,wR2=0.142 7.在该晶体的结构中,带相反电荷的多阴离子簇和大阳离子簇在空间交替排列,通过离子键及抗衡阳离子K 和Na 的弱配位键连接形成了具有一维孔洞的三维开放式结构,孔洞尺寸为1.31 nm×1.09 nm.     

BESⅢ主触发系统VME机箱快控制插件的设计

提出了“可预置计数限的计数逻辑”和“有暂停控制的双向计数器逻辑”,解决了VME总线主板所能处理的中断的频率与输入信号脉冲的频率不匹配的难题,消除了某些信号与系统时钟异步造成的准稳态;所设计的插件实现了VME总线程控流水线式发中断的功能．