ON THE ORDERING OF A CLASS OF HEXAGONAL CHAINS WITH RESPECT TO MERRIFIELD-SIMMONS INDEX

A hexagonal system is regarded as a 2-connected plane graph in which every finite region is aregular hexagon of unit side length. Hexagonal systems are of great importance for theoreticalchemistry because they are the natural graph representation of benzenoid hydrocarbonsll].Merrifield-Simmons index of a hexagonal system was extensively studied in connection withcertain topological problems of chemistry[']. A hexagonal chain is a hexagonal system with theproperties that (a) it has no vertex be…     

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases.     

氯苯处理下小麦幼根生理学指标的变化及活性炭对氯苯毒性缓解作用的研究

以小麦幼根为材料,研究了不同浓度氯苯(1％,2％,3％,4％,5％)对小麦幼根生理学指标的影响及活性炭对小麦幼根的保护作用.结果显示,氯苯造成了小麦幼根生物量(根长、鲜重和干重)的下降,同时升高了小麦幼根细胞死亡水平、可溶性蛋白含量、丙二醛含量、活性氧含量以及抗氧化酶活性.表明氯苯对小麦幼根造成生长抑制,增加了氧化压力...     

价值工程方法在矿用链条加工中的应用研究

运用价值分析法对矿用高强度圆环链的加工过程进行诊断分析,通过对象选择、功能系统分析、功能评价,提出优化方案,降低了原材料成本,从而提高链条企业的经济效益.     

石家庄市多年降水分析及雨水利用研究

主要介绍了石家庄市的水资源短缺情况,通过对该市54年降水资料的分析,指出了实施城市雨水资源利用的重大意义和可行性,并结合雨水水质分析提出了石家庄市雨水利用的方法,即雨水初期弃流后,经过滤、沉淀、消毒进入储水池,用于绿化、洗车及喷洒路面等,该工艺可首先用在生活小区和机关事业单位。     

可重构智能表面辅助大规模MIMO通信波束成形设计

可重构智能表面(reconfigurable intelligent surface, RIS)在无线通信系统中能够提高信道性能。为了降低传统波束成形方案中功率分配的复杂度,结合毫米波(millimeter wave, mmWave)特点建立信道模型,提出一种基于正交匹配追踪(orthogonal matching pursuit, OMP)和统一信道分解(uniform channel decomposition, UCD)的RIS辅助mmWave多输入多输出(multiple input multiple output, MIMO)系统混合波束成形设计方案。利用视距(line of sight, LoS)信道的到达角(angle of arrival, AoA)和离开角(angle of departure, AoD)设计了RIS的反射矩阵。该方法不需要复杂的功率分配,能够使得多个并行数据流具有相同的信道增益。仿真结果表明,该混合波束成形方案具有更好的误比特率(bit error rate, BER)性能及频谱效率。     

数值逆吊法创建的自由曲面结构形态及稳定性分析

应用数值逆吊法,创建多种力与形和谐统一的自由曲面结构形态,并与传统规则曲面结构进行了稳定性能的对比分析.以薄壳找形为例,将原始结构的几何条件和物理条件转化为参数化数值,输入ANSYS中进行建模和迭代找形,然后将平衡后的模型进行翻转,得到数值逆吊法创建的薄壳结构模型,然后改变不同工况下的荷载分布,进行静力分析和稳定性分析...     

具有钙钛矿结构的分子铁电体研究进展

铁电材料是一类重要的功能性材料,由于其特殊的可翻转的自发极化,铁电材料在能源、信息、传感、医学等领域都有着广泛的应用.自20世纪以来,具有钙钛矿结构的铁电材料由于其优异的性质一直活跃在应用的舞台上,而其中应用较为广泛的几乎都是无机钙钛矿材料.近年来,随着科学技术的发展,人们发现了众多具有钙钛矿结构的分子铁电体.这些新型的分子铁电体具有较低的声阻抗、容易进行结构设计和调控、容易实现多种功能特性等优点,有望在柔性电子学、薄膜器件等应用中成为无机钙钛矿铁电材料的有益补充.本文结合分子钙钛矿铁电体的设计思路,对近年来其在压电、能隙调控、光电等功能特性方面取得的进展进行了介绍.     

超细Fe-ZSM-5分子筛的原位合成及其甲醇制丙烯性能

采用干凝胶法原位合成出颗粒粒径约为50～120 nm且含骨架杂原子的超细Fe-ZSM-5分子筛,利用X射线衍射(XRD)、扫描电镜(SEM)、透射电镜(TEM)、紫外-可见光光谱仪(UV-Vis)、氨的程序升温脱附(NH₃-TPD)、吡啶吸附红外光谱(Py-FT-IR)和N₂吸附-脱附等手段对样品进行表征。结果表明：原位添加的Fe源不仅可以降低分子筛颗粒粒径,还能降低分子筛酸强度;原位合成的Fe-ZSM-5分子筛中Fe物种主要以四配位骨架Fe³⁺存在,其余以低聚的FeO_x以及Fe₂O₃颗粒存在,而浸渍法制备的Fe/ZSM-5分子筛中Fe物种主要以后2种形式存在;Fe改性调变了ZSM-5分子筛的酸性质,从而提高了MTP反应产物丙烯的选择性;与负载型Fe/ZSM-5分子筛催化剂相比,原位改性的含骨架杂原子超细Fe-ZSM-5分子筛催化剂由于具有更小的晶粒粒径和适宜的酸性质,从而进一步提高了丙烯选择性。     

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

We present an approximate conditional and joint association analysis that can use summary-level statistics from a meta-analysis of genome-wide association studies (GWAS) and estimated linkage disequilibrium (LD) from a reference sample with individual-level genotype data. Using this method, we analyzed meta-analysis summary data from the GIANT Consortium for height and body mass index (BMI), with the LD structure estimated from genotype data in two independent cohorts. We identified 36 loci with multiple associated variants for height (38 leading and 49 additional SNPs, 87 in total) via a genome-wide SNP selection procedure. The 49 new SNPs explain approximately 1.3% of variance, nearly doubling the heritability explained at the 36 loci. We did not find any locus showing multiple associated SNPs for BMI. The method we present is computationally fast and is also applicable to case-control data, which we demonstrate in an example from meta-analysis of type 2 diabetes by the DIAGRAM Consortium.