单纯及丙泊酚联合电休克对抑郁大鼠海马TNF—α表达的影响

目的探讨单纯电休克及丙泊酚联合电休克对抑郁大鼠电休克治疗效果及海马内TNF-α表达的影响。方法50只成年Wistar大鼠随机分为5组（n=10）：正常对照组（C组）、抑郁组（D组）、单纯丙泊酚组（DP组）、单纯电休克组（E组）、丙泊酚联合电休克组（M组）。C组正常饲养,其余采用经典的慢性不可预见性应激法建立抑郁模型。建模成功后,E组直接行电休克治疗,M组腹腔注射丙泊酚90mg／kg,麻醉产生效应后行电休克治疗,每日进行以上处理1次,连续7日。以Open—field法和糖水消耗实验进行行为学评分。实验完成后处死大鼠,用免疫组化染色法检测TNF—α受体蛋白的表达;ELISA法海马TNF-α的含量,RT-PCR法测海马TNF—α mRNA表达。结果E组和M组大鼠的行为学评分高于D组和DP组,且M组高于E组（P〈0．05）;D组和DP组海马内TNF-α含量以及mRNA的表达高于其它各组（P〈0．05）,M组海马内TNF—α含量以及mRNA的表达低于E组（P〈0．05）,与C组差异无统计学意义（P〉0．05）;D组和DP组海马区TNF-α受体表达量低于C组（P〈0．05）,M组的表达量接近于C组,但高于E组（P〈0．05）。结论慢性应激使大鼠海马内TNF—α含量升高及其受体表达下调,从而产生抑郁症。丙泊酚可以改善电休克抑郁症状可能与进一步下调抑郁大鼠海马内TNF—α的含量和上调其受体表达有关。     

Feature network-driven quadrant mapping for summarizing customer reviews

With the rapid growth of e-commerce, customers increasingly write online reviews of the product they purchase. These customer reviews are one of the most valuable sources of information affecting selection of products or services. Summarizing these customer reviews is becoming an interesting area of research, inspiring researchers to develop a more condensed, concise summarization for users. However, most of the current efforts at summarization are based on general product features without feature’s relationship. As a result, these summaries either ignore feedback from customers or do a poor job of reflecting the opinions expressed in customer reviews. To remedy this summarization shortcoming, we propose a feature network-driven quadrant mapping that captures and incorporates opinions from customer reviews. Our focus is on construction of a feature network, which is based on co-occurrence and sematic similarities, and a quadrant display showing the opinions polarity of feature groups. Moreover, the proposed approach involves clustering similar product features, and thus, it is different from standard text summarization based on abstraction and extraction. The summarized results can help customers better understand the overall opinions about a product.     

New results on the robust stability analysis of neural networks with discrete and distributed time delays

Delay-dependent robust stability of cellular neural networks with time-varying discrete and distributed time-varying delays is considered. Based on Lyapunov stability theory and the linear matrix inequality （LMIs） technique, delay-dependent stability criteria are derived in terms of LMIs avoiding bounding certain cross terms, which often leads to conservatism. The effectiveness of the proposed stability criteria and the improvement over the existing results are illustrated in the numerical examples.     

液基细胞学检查技术在临床肿瘤筛查的研究进展

液基细胞学检查技术是目前脱落细胞检查技术中的最优质的制片技术,对脱落细胞进行液基细胞学检查制片并观察诊断,可以提高对脱落细胞的恶性肿瘤检出率.本文通过对目前我国正在采用的各种液基细胞学检查技术的原理及其特点进行阐述,并对宫颈脱落细胞、体腔积液、尿液、痰液、纤支镜、细针穿刺及肛管直肠脱落细胞的应用及其前景提出改进,供临床细胞学病理检查工作者进行参考选择,以进一步普及液基细胞学检查的应用,提高时恶性肿瘤的早期诊断.     

Analysis on Influential Factors of Corporate Environmental Management Level Based on ISM

Environmental problem is one of complicated social problems. According to the level of corporate environmental management, there are many influential factors, and their relations are also complicated. In this paper, we analyzed influential factors of corporate environmental management through consultation of experts. And based on the analysis, we applied interpretative structural modeling（ISM） to classify 13 influential factors into 3 levels. We hope it will be useful for the subsequent research and evaluation of corporate environmental management level.     

风机振动分析与故障诊断

应用振动分析方法、数据采集技术及诊断理论对某乙烯厂Ｅ－ＧＢ１０９风机进行了现场振动测量、信号的采集与分析诊断,找出了风机振动的原因。     

Φ180TCM三辊连轧管机组隧道机座焊接工艺研究

Φ180TCM三辊连轧管机组成套设备是太重集团自主研发的新型轧管设备,打破了欧美企业在该领域对市场的垄断。该成套设备中包含有千吨以上的焊接毛坯,而在焊接毛坯中,隧道机座的焊接尤为重要,不仅因其要求精度高,关键是其在整套设备中起着支撑起整套设备的作用,有些关键部位由于加工难度高,需要焊接保证最终的尺寸要求,对焊接工艺要求苛刻。     

基于FPGA的交流伺服系统电流环带宽扩展

在电流环的数学模型基础上,分析了电流环带宽与电流环路延时的关系,比较了几种典型电流环时序下产生的延时,对电流采样和PWM占空比更新时序进行了改进,并在FPGA中得到了具体的验证和实现.实验结果表明:这种改进的电流环时序克服了原有电流环时序的问题,能在不改变功率器件开关频率和不损失输出电压能力的基础上减小电流环路延时,从而提高电流环带宽,改善电流环和速度环的控制性能.     

基于创新人才培养的学科文化建设

学科文化是指在特定时期内学科本身所具有的价值观念、知识体系及其成员特有的精神风貌和相应行为的总和.学科文化在创新人才培养中具有塑造创新人格、培养创新思维、提升创新技能和营造创新环境功能,基于创新人才培养的学科文化建设要注重学科精神文化的提炼与创新,遴选学科带头人,凝聚学科力量,以激励创新为目的,逐步完善学科制度建设,做好学科物质文化的规划与建设.     

浅议马克思主义的自由观

自由,是人类永恒追求的真理之一.在人类对自由的历史探索中,不同的思想家对自由的理解各有不同.其中较重要的就是以西方文化为代表的新自由主义.随着新自由主义在经济领域的应用而生成的自由市场至上主义思想的发展,显然,对当今全球金融危机的发生负有不可推卸的责任.所以,此时重申马克思主义自由观,对于我们理解、把握这个时代具有重大意义.