基于智能体模拟的结构性疏散计划设计研究

展示了一个基于Agent模拟方法的框架方法,用于为危急中的复杂技术系统设计结构性的疏散计划.该计划利用复杂自适应系统的模拟方式,并采用基于智能体模拟的方法作为认知工具来设计整体系统的疏散方案.结构化的疏散计划应用文中提出的整体性技术框架,没有采用标准化的常规方法.提出了一个使疏散人群能够更加适应的调整危机时刻的紧急情况和减少无效疏散的建议性方案.本框架方法在一个典型的复杂自适应系统一地铁火灾中得到应用.     

三维地学建模技术与Kriging方法在固体矿产储量计算中的应用

结合Kriging方法在计算机上的实现和应用,介绍了运用三维地学建模技术生成矿体的三维品位模型的原理流程以及关键技术,并在此基础上进行矿产资源储最计算.其基本流程为:根据实际地质勘探数据生成矿体三维实体模型;在实体tin模型内部应用块模型方法进行划分,建立矿体块体模型;利用Kriging方法进行插值,生成矿体的品位模型...     

施工企业防范经营风险初探

施工企业经营风险是指企业在经营中对未来经营环境中的不确定因素与多变性无法全部或精确预测所造成预计支出与收益偏离实际的风险。企业经营风险是在经营过程中产生的,因此,经营风险贯穿于企业生产经营的全过程。     

混合方法优化的自适应引力搜索算法

针对引力搜索算法存在的易早熟收敛、易陷入局部最优、搜索精度有待提高等缺陷,提出一种混合方法优化的自适应引力搜索算法（gravitational search algorithm,GSA）。首先利用Sobol序列初始化种群,增强算法全局搜索能力;其次引入Hamming贴进度计算种群成熟度,判断种群是否早熟;然后引入Logistic混沌对种群作混沌搜索,变异已陷入局部最优的粒子位置;最后基于早熟收敛判断因子改进引力系数,并为粒子位置公式添加收缩因子,促使种群加快脱离局部最优。对9个不同类型的基准测试函数做仿真实验,结果表明新算法能有效改善种群的早熟问题,具备更好的寻优性能。     

同时存在导体和电介质的边界时电像法问题研究

讨论了导体与电介质同时存在情况下的电像法问题,指出了文献[1-2]中关于这一问题所出现的一些错误,并给出了正确的解答.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

Game-theoretic approach to power and admission control in hierarchical wireless sensor networks

Power efficiency and link reliability are of great importance in hierarchical wireless sensor networks (HWSNs),especially at the key level,which consists of sensor nodes located only one hop away from the sink node called OHS.The power and admission control problem in HWSNs is comsidered to improve its power efficiency and link reliability.This problem is modeled as a non-cooperative game in which the active OHSs are considered as players.By applying a double-pricing scheme in the definition of OHSs’ utility function,a Nash Equilibrium solution with network properties is derived.Besides,a distributed algorithm is also proposed to show the dynamic processes to achieve Nash Equilibrium.Finally,the simulation results demonstrate the effectiveness of the proposed algorithm.     

一维双极粘滞量子流体力学模型解的存在性

研究了一类一维稳态双极半导体方程的粘滞量子流体力学模型.该模型包含关于粒子浓度和电流密度的连续方程以及电势Poisson方程的耦合方程组,其中含有三阶量子修正项和二阶粘滞项.该问题在有界区间(0,1)中讨论,并通过边界条件的假设将原方程组变形为常见的形式,得到原问题的等价问题.用截断方法将等价问题正则化,并得到正则化问题解的先验估计.利用Leray-Schauder不动点定理证明正则化问题解的存在性,最后通过L∞估计证明正则化问题的解即为原问题的解,从而证明了原双极粘滞量子流体力学模型存在稳态解.     

中国经济增长的动因分析与政府作用

分析了中国经济快速发展的原因,认为经济增长源于资本、劳动力等要素的不断积累和资源的优化配置,而技术进步和制度的改革与完善则强化了这一过程,在这个过程中,政府起到很大作用。