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191.
运用自然坐标法研究了空间4-UPU(万向铰-移动铰-万向铰)并联机器人的运动学正解问题.通过共用并联机器人两两构件间的公共点或公共向量的笛卡尔坐标减少自然坐标的数量,从而简化了整个分析过程.在用自然坐标法处理多体机器人系统时,由于变量仅仅引进了末端执行器上关键点的笛卡尔坐标,因此,约束方程或者是二次的或者是线性的,这就使得并联机器人的运动学分析中不会出现任何超越函数.该建模过程方法简单、统一,非常有利于计算机编程处理. 相似文献
192.
193.
在车体产品数据模块和数据库功能分析的基础上,建立以SQL Server 2000为后台数据库,以Java为W eb Service开发工具的工程数据库系统,完成前台功能化查询、可视化查询和参数化查询的功能设计.数据库内存储所有已建CAD模型和CAE模型的一般信息、分析结果信息及模型指针.该数据库系统管理设计过程、图纸文件、设计结果和分析结果,支持产品的设计变更、审批和发布,实现快速设计信息的检索与查询.实际应用表明,该系统能有效地管理车体开发中的产品数据. 相似文献
194.
给出了证券组合模型, 在其使对称矩阵与对角矩阵合同的可逆阵的一般规律基础上, 推导出证券投资组合给合权数的解析表达式, 并给出实例验证. 相似文献
195.
通过增加车辆预留能力系数,保证在避免货物重新排列的情况下完成取送货.充分考虑物流运输行业的现状,重点研究相关参数模糊且各取货节点动态随机出现的问题.在求解方法上,首先为车辆路线中每一个节点、车辆以及相邻节点间的路径建立标签,并建立初始路径;其次,通过标签插入方法求解模糊动态问题;最后给出了方案应用失败后的处理方法.仿真实例验证了所提方法的有效性. 相似文献
196.
RK Koenekoop H Wang J Majewski X Wang I Lopez H Ren Y Chen Y Li GA Fishman M Genead J Schwartzentruber N Solanki EI Traboulsi J Cheng CV Logan M McKibbin BE Hayward DA Parry CA Johnson M Nageeb;Finding of Rare Disease Genes 《Nature genetics》2012,44(9):1035-1039
Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder. 相似文献
197.
The TFT‐LCD (thin‐film transistor–liquid crystal display) industry is one of the key global industries with products that have high clock speed. In this research, the LCD monitor market is considered for an empirical study on hierarchical forecasting (HF). The proposed HF methodology consists of five steps. First, the three hierarchical levels of the LCD monitor market are identified. Second, several exogenously driven factors that significantly affect the demand for LCD monitors are identified at each level of product hierarchy. Third, the three forecasting techniques—regression analysis, transfer function, and simultaneous equations model—are combined to forecast future demand at each hierarchical level. Fourth, various forecasting approaches and disaggregating proportion methods are adopted to obtain consistent demand forecasts at each hierarchical level. Finally, the forecast errors with different forecasting approaches are assessed in order to determine the best forecasting level and the best forecasting approach. The findings show that the best forecast results can be obtained by using the middle‐out forecasting approach. These results could guide LCD manufacturers and brand owners on ways to forecast future market demands. Copyright 2008 John Wiley & Sons, Ltd. 相似文献
198.
Tan L Li X Liu F Sun X Li C Zhu Z Fu Y Cai H Wang X Xie D Sun C 《Nature genetics》2008,40(11):1360-1364
The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication. 相似文献
199.
Chan TL Yuen ST Kong CK Chan YW Chan AS Ng WF Tsui WY Lo MW Tam WY Li VS Leung SY 《Nature genetics》2006,38(10):1178-1183
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy. 相似文献
200.
建立内生增长模型研究金融系统资源配置功能如何促进经济增长 .结论 :通过提高“创新平均成功概率”,增加“创新投资比例”、“储蓄转化比例”和储蓄率 ,金融系统能够促进经济快速稳定增长 .另外本文还得到产出 -资本比“阶跃”增长图象. 相似文献