全文获取类型
收费全文 | 17337篇 |
免费 | 42篇 |
国内免费 | 55篇 |
专业分类
系统科学 | 254篇 |
丛书文集 | 487篇 |
教育与普及 | 36篇 |
理论与方法论 | 50篇 |
现状及发展 | 7973篇 |
研究方法 | 724篇 |
综合类 | 7762篇 |
自然研究 | 148篇 |
出版年
2012年 | 206篇 |
2011年 | 409篇 |
2010年 | 97篇 |
2009年 | 97篇 |
2008年 | 271篇 |
2007年 | 346篇 |
2006年 | 290篇 |
2005年 | 298篇 |
2004年 | 273篇 |
2003年 | 327篇 |
2002年 | 261篇 |
2001年 | 609篇 |
2000年 | 609篇 |
1999年 | 344篇 |
1992年 | 328篇 |
1991年 | 254篇 |
1990年 | 298篇 |
1989年 | 271篇 |
1988年 | 262篇 |
1987年 | 276篇 |
1986年 | 284篇 |
1985年 | 338篇 |
1984年 | 242篇 |
1983年 | 219篇 |
1982年 | 200篇 |
1981年 | 238篇 |
1980年 | 261篇 |
1979年 | 569篇 |
1978年 | 463篇 |
1977年 | 469篇 |
1976年 | 351篇 |
1975年 | 374篇 |
1974年 | 583篇 |
1973年 | 455篇 |
1972年 | 413篇 |
1971年 | 510篇 |
1970年 | 656篇 |
1969年 | 573篇 |
1968年 | 493篇 |
1967年 | 528篇 |
1966年 | 439篇 |
1965年 | 330篇 |
1964年 | 86篇 |
1959年 | 209篇 |
1958年 | 318篇 |
1957年 | 208篇 |
1956年 | 181篇 |
1955年 | 180篇 |
1954年 | 177篇 |
1948年 | 94篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Marth G Yeh R Minton M Donaldson R Li Q Duan S Davenport R Miller RD Kwok PY 《Nature genetics》2001,27(4):371-372
There is a concerted effort by a number of public and private groups to identify a large set of human single-nucleotide polymorphisms (SNPs). As of March 2001, 2.84 million SNPs have been deposited in the public database, dbSNP, at the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/SNP/). The 2.84 million SNPs can be grouped into 1.65 million non-redundant SNPs. As part of the International SNP Map Working Group, we recently published a high-density SNP map of the human genome consisting of 1.42 million SNPs (ref. 3). In addition, numerous SNPs are maintained in proprietary databases. Our survey of more than 1,200 SNPs indicates that more than 80% of TSC and Washington University candidate SNPs are polymorphic and that approximately 50% of the candidate SNPs from these two sources are common SNPs (with minor allele frequency of > or =20%) in any given population. 相似文献
992.
Grimm DR Colter MB Braunschweig M Alexander LJ Neame PJ Kim HK 《Cellular and molecular life sciences : CMLS》2001,58(1):148-159
Factor V is a plasma protein essential for blood coagulation. This protein is involved in activated protein C resistance,
the most common inherited thrombotic disorder known. We utilized the polymerase chain reaction to clone the porcine factor
V gene by generating overlapping clones amplified with primers chosen by comparison with known nucleotide sequences. The porcine
factor V cDNA contig encodes a predicted 2258-amino acid protein, making it the largest in comparison to the bovine, human,
and murine proteins. Porcine factor V has the highest level of homology with bovine factor V, but also has high levels of
conservation of important residues with all the species. Radiation hybrid mapping assigned the porcine factor V gene to chromosome
4. Three-dimensional models of factor V were generated and used to analyze membrane-binding sites in terms of conserved, and
therefore likely important residues.
Received 3 October 2000; revised 23 November 2000; accepted 6 December 2000 相似文献
993.
Larbalestier DC Cooley LD Rikel MO Polyanskii AA Jiang J Patnaik S Cai XY Feldmann DM Gurevich A Squitieri AA Naus MT Eom CB Hellstrom EE Cava RJ Regan KA Rogado N Hayward MA He T Slusky JS Khalifah P Inumaru K Haas M 《Nature》2001,410(6825):186-189
The discovery of superconductivity at 39 K in magnesium diboride, MgB2, raises many issues, a critical one being whether this material resembles a high-temperature copper oxide superconductor or a low-temperature metallic superconductor in terms of its behaviour in strong magnetic fields. Although the copper oxides exhibit very high transition temperatures, their in-field performance is compromized by their large anisotropy, the result of which is to restrict high bulk current densities to a region much less than the full magnetic-field-temperature (H-T) space over which superconductivity is found. Moreover, the weak coupling across grain boundaries makes transport current densities in untextured polycrystalline samples low and strongly sensitive to magnetic field. Here we report that, despite the multiphase, untextured, microscale, subdivided nature of our MgB2 samples, supercurrents flow throughout the material without exhibiting strong sensitivity to weak magnetic fields. Our combined magnetization, magneto-optical, microscopy and X-ray investigations show that the supercurrent density is mostly determined by flux pinning, rather than by the grain boundary connectivity. Our results therefore suggest that this new superconductor class is not compromized by weak-link problems, a conclusion of significance for practical applications if higher temperature analogues of this compound can be discovered. 相似文献
994.
995.
Simulating the amplification of orbital forcing by ocean feedbacks in the last glaciation 总被引:2,自引:0,他引:2
According to Milankovitch theory, the lower summer insolation at high latitudes about 115,000 years ago allowed winter snow to persist throughout summer, leading to ice-sheet build-up and glaciation. But attempts to simulate the last glaciation using global atmospheric models have failed to produce this outcome when forced by insolation changes only. These results point towards the importance of feedback effects-for example, through changes in vegetation or the ocean circulation-for the amplification of solar forcing. Here we present a fully coupled ocean-atmosphere model of the last glaciation that produces a build-up of perennial snow cover at known locations of ice sheets during this period. We show that ocean feedbacks lead to a cooling of the high northern latitudes, along with an increase in atmospheric moisture transport from the Equator to the poles. These changes agree with available geological data and, together, they lead to an increased delivery of snow to high northern latitudes. The mechanism we present explains the onset of glaciation-which would be amplified by changes in vegetation-in response to weak orbital forcing. 相似文献
996.
997.
998.
999.
Understanding the relative timings of climate events in the Northern and Southern hemispheres is a prerequisite for determining the causes of abrupt climate changes. But climate records from the Patagonian Andes and New Zealand for the period of transition from glacial to interglacial conditions--about 14.6-10 kyr before present, as determined by radiocarbon dating--show varying degrees of correlation with similar records from the Northern Hemisphere. It is necessary to resolve these apparent discrepancies in order to be able to assess the relative roles of Northern Hemisphere ice sheets and oceanic, atmospheric and astronomical influences in initiating climate change in the late-glacial period. Here we report pollen records from three sites in the Lake District of southern Chile (41 degrees S) from which we infer conditions similar to modern climate between about 13 and 12.2 14C kyr before present (BP), followed by cooling events at about 12.2 and 11.4 14C kyr BP, and then by a warming at about 9.8 14C kyr BP. These events were nearly synchronous with important palaeoclimate changes recorded in the North Atlantic region, supporting the idea that interhemispheric linkage through the atmosphere was the primary control on climate during the last deglaciation. In other regions of the Southern Hemisphere, where climate events are not in phase with those in the Northern Hemisphere, local oceanic influences may have counteracted the effects that propagated through the atmosphere. 相似文献
1000.
Most interpretations of early hominin phylogeny recognize a single early to middle Pliocene ancestral lineage, best represented by Australopithecus afarensis, which gave rise to a radiation of taxa in the late Pliocene. Here we report on new fossils discovered west of Lake Turkana, Kenya, which differ markedly from those of contemporary A. afarensis, indicating that hominin taxonomic diversity extended back, well into the middle Pliocene. A 3.5 Myr-old cranium, showing a unique combination of derived facial and primitive neurocranial features, is assigned to a new genus of hominin. These findings point to an early diet-driven adaptive radiation, provide new insight on the association of hominin craniodental features, and have implications for our understanding of Plio-Pleistocene hominin phylogeny. 相似文献