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991.
DENGShenghui YANGXiaoju ZHOUZhiyan 《科学通报(英文版)》2004,49(16):1774-1776
Ginkgo is a very important gymnospermous genus that has only one surviving species, Ginkgo biloba L. As a so-called “living fossil“, wild Ginkgo was found only in China, but it once flourished well and had a world-wide distribution in the Mesozoic. The earliest Ginkgo has been known from the Middle Jurassic, based on ovule-bearin gorgans. In the Jurassic and Early Cretaceous, Ginkgo was one of the dominant gymnosperms in floras and possibly one of the coal-forming plants in North China. During the Early Tertiary, it reduced to a circumpolar distribution in the North Hemisphere; only a few reported from the South Hemisphere. From the Pliocene onwards, the Ginkgoales has been represented by the extant monotypic “living fossil“ Ginkgo biloba. 相似文献
992.
LIUShiyong ZHANGZhiyuan SONGYechun QIUKejun ZHANGKecheng ANNing ZHOUZheng CAIWenqin YANGHui 《科学通报(英文版)》2004,49(11):1126-1136
The neural stem cells in the anterior subventricular zone (SVZa) mainly generate the progenitors that will differentiate into neurons, and along a highly circumscribed migratory access Rostral migratory stream (RMS), they migrate to the olfactory bulbs (OB). To understand the effects of BMPs on SVZa neural stem cells, in this study BMP4 at various concentrations was used to induce SVZa neural stem cells, and the living cell labeling using BMP4 promotor conjugated with red fluorescence protein showed the expression of BMP4 dynamically. The results demonstrated that low BMP4 doses (1-5 ng/mL) promoted while high doses (10-100 ng/mL) inhibited the proliferation of SVZa neural stem cells, and BMP4 promotedneuron differentiation in the early stage (1-3 d), howeverm, it inhibited the neuron commitment after 4 d. Noggin, the antagonist of BMP4, blocked the physiological effects of BMP4. In OB, BMP4 is mainly to accelerate the progenitors to withdraw from the cell cycle and trigger the differentiation, and in RMS, it promotes the proliferation of committed progenitors and not differentiation, further in SVZa, BMP4 enhances astrocyte commitment. 相似文献
993.
HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains 总被引:4,自引:0,他引:4
Jiang JL Chan HC Zhou Q Yu MK Yao XY Lam SY Zhu H Ho LS Leung KM Chen ZN 《Cellular and molecular life sciences : CMLS》2004,61(16):2083-2091
HAb18G/CD147 is a heavily glycosylated protein containing two immunoglobulin superfamily domains. Our previous studies have indicated that overexpression of HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca2+ entry by nitric oxide (NO)/cGMP. In the present study, we investigated the structure-function of HAb18G/CD147 by transfecting truncated HAb18G/CD147 fragments into human 7721 hepatoma cells. The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721C and T7721N cells, respectively. The potential effect of HAb18G/CD147 on metastatic potentials, both adhesion and invasion capacities, of hepatoma cells was abolished in T7721C cells, but not affected in T7721N cells. Release and activation of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, were found to be enhanced by the expression of HAb18G/CD147, and this effect was abolished by both truncations. Thapsigargin significantly enhanced release and activation of MMPs (MMP-2 and MMP-9) in non-transfected 7721 cells, and this effect was negatively regulated by SNAP. However, no effects of thapsigargin or SNAP were observed in T7721 cells, and expression of HAb18G/CD147 enhanced secretion and activation of MMPs at a stable and high level. Taken together, these results suggest that both ectodomain and intracellular domains of HAb18G/CD147 are required to mediate the effect of HAb18G/CD147 on the secretion and activation of MMPs and metastasis-related processes in human hepatoma cells by disrupting the regulation of NO/cGMP-sensitive intracellular Ca2+ mobilization although each domain may play different roles.Received 1 April 2004; received after revision 15 June 2004; accepted 22 June 2004 相似文献
994.
HeChun-yan ZhouXin LiXiao-ming YuHong HongJia-ling 《武汉大学学报:自然科学英文版》2004,9(1):120-124
The present study was undertaken to investigate the effect of oxidized low density lipoprotein (oxLDL) on the expression of maerophage matrix metalloproteinase-12 (MMP-12), and the possible mechanisms. Activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was detected by Western blot analysis.Enzymatic activity of MMP-12 was determined by β-casein zymography. RT-PCR analysis was used to measure the mRNA expression level of MMP-12. OxLDL-stimulated macrophages produced increased casein-degrading activities and oxLDL also significantly increased the mRNA level of MMP-12 in a dose-dependent manner.OxLDL stimulated the phosphorylation of ERK1/2 in macrophages. The use of the specific inhibitor indicated that the ERK1/2 signaling pathway was required for the induction of MMP-12.These data demonstrated that oxLDL induced MMP-12 expression in macrophages through an ERK1/2-dependent pathway. 相似文献
995.
Science Letters:Synergetic effects for p-nitrophenol abatement using a combined activated carbon adsorption-electrooxidation process 总被引:1,自引:0,他引:1
A novel fluidized electrochemical reactor that integrated advanced electrochemical oxidation with activated carbon (AC) fluidization in a single cell was developed to model pollutant p-nitrophenol (PNP) abatement. AC fluidization could enhance COD removal by 22%-30%. In such a combined process, synergetic effects on PNP and COD removal was found, with their removal rate being enhanced by 137.8% and 97.8%, respectively. AC could be electrochemically regenerated and reused, indicating the combined process would be promising for treatment of biorefractory organic pollutants. 相似文献
996.
通过对皖西学院计算机系专业学生上网情况的深入调查,以班会的形式来教育学生,以“网络给我们带来了什么”这个主题来展开讨论,让学生在讨论中提高认识。同时我们系教师主动出击,挺进网络阵地,开拓了德育教育的新天地。在看到网络文化给我们计算机系学生德育工作带来挑战与冲击的同时,也看到了它作为一个新的育人环境,新的教育模式,新的工作手段和新的工作栽体的巨大潜力,充分发挥网络的优势,用丰富的德育内容,健康的班级文化,独具一格的班级网页,直接快捷的共同聊天室和班主任电子信箱,将网络转化为培养学生健康成长的前沿阵地,成为熏陶学生思想健康发展的崭新领域,正是我们高等学校学生德育工作者与时俱进、开拓进取,探索德育最佳途径的新目标和努力方向。 相似文献
997.
本文利用系统动力学的方法对安微省农户的生产、消费和积累三方面的经济行为进行研究。探讨了农户在现有的生产条件和政策环境下生产、消费和积累的特点及其发展趋势,并提出了应该采取的对策。 相似文献
998.
A long-tailed,seed-eating bird from the Early Cretaceous of China 总被引:23,自引:0,他引:23
The lacustrine deposits of the Yixian and Jiufotang Formations in the Early Cretaceous Jehol Group in the western Liaoning area of northeast China are well known for preserving feathered dinosaurs, primitive birds and mammals. Here we report a large basal bird, Jeholornis prima gen. et sp. nov., from the Jiufotang Formation. This bird is distinctively different from other known birds of the Early Cretaceous period in retaining a long skeletal tail with unexpected elongated prezygopophyses and chevrons, resembling that of dromaeosaurids, providing a further link between birds and non-avian theropods. Despite its basal position in early avian evolution, the advanced features of the pectoral girdle and the carpal trochlea of the carpometacarpus of Jeholornis indicate the capability of powerful flight. The dozens of beautifully preserved ovules of unknown plant taxa in the stomach represents direct evidence for seed-eating adaptation in birds of the Mesozoic era. 相似文献
999.
Qiuli?Li Shuguang?LiEmail author Hongying?Zhou Huimin?Li Ji’an?Hong Qingchen?Wang H.?J.?Massonne 《科学通报(英文版)》2002,47(1):62-65
The U-Pb isotope compositions of rutile, omphacite and garnet in the eclogite from the Jinheqiao area in the Southern Dabie ultrahigh-pressure metamorphic zone were analyzed. The consistent high precision U-Pb age (218 ± 1.2) Ma of rutile in eclogite from the Dabie Mountains was obtained by two ways of isochron and common Pb correction based on the composition of omphacite. This proves that the omphacite in eclogite has a U/Pb ratio (m = 2.8) low enough to be used for common Pb correction in the analyses of rutile. Under the rapid cooling condition (40℃/Ma) the closure temperature for U-Pb diffusion in rutile is about 470℃. Thus, this U-Pb age of rutile proves that 218 Ma should be the cooling age of eclogite at 470℃ instead of the peak metamorphic age. 相似文献
1000.
非线性单纯形的修改算法 总被引:5,自引:0,他引:5
提出了非线性单纯形算法的修改算法。在原单纯形算法的基础上增加了一种新的反射方向的计算方法;用“映射单纯形”方法代替“单纯形顶点代换”方法;有选择地采用“单纯形压缩”计算。修改单纯形算法对初值的适应范围更亮、能有效加快收敛速度。 相似文献