A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://highwire.stanford.edu/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates.     

基于人性技术化与技术人性化的哲学思考

人性技术化和技术人性化是技术与人性关系的两极,也是技术双刃剑特性基于人性的重要表现.对其深层解读和哲学思考,以揭示人性技术化与技术人性化的本质,及其对人性的影响,进而探索由人性技术化的社会现实向技术人性化的理论构想进行转变的路径,对于技术的当代发展有重要意义.     

煤气管道服役期预估神经网络模型的建立与应用

神经网络模型具备的针对大量无规则数据自学习的能力,适于解决城镇煤气管道布局复杂、影响因素众多、服役期限难以计算的问题。基于BP神经网络算法建立的煤气管道年限模型,经过训练对比,选择了最优的BP网络模型,结合共轭梯度法,改进了该算法收敛慢、易出现震荡的问题,实现了对城镇管道漏损的定量分析,结合某市煤气管道漏损的实际案例验证其可行性,满足预估管道服役期限的工程要求。     

Recognition and sensing of anions through synergistic effects using simple benzimidazolium-urea receptors

Benzimidazolium-based receptors 1-3 were designed and synthesized. On the basis of fluorescence, UV-Vis, and 1H NMR spectroscopic studies, and X-ray single crystal structure analysis, it was confirmed that the receptor 1 displays strong (C-H)+···X, N-H···X hydrogen bonds and charge-charge interactions with anions. More importantly, these investigations demonstrated that the charged (C-H)+ benzimidazolium and urea moieties play a synergistic role in anion recognition.     

Synthesis process of Ba-ferrites from α-FeOOH and γ-FeOOH and investigation of magnetic properties

The claviform BaFe₁₂O₁₉ crystals were synthesized by the precipitation-toptactic reaction method using α-FeOOH and γ-FeOOH as raw materials respectively. The synthesis processes of BaFe₁₂O₁₉, studied by XRD, SEM, EDS, FT-IR, and TG-DTA techniques, included preparations of precursor γ and precursor α, formations of α-Fe₂O₃ and BaFe₂O₄, and production of rod-like BaFe₁₂O₁₉ through dehydroxylation of pod-like FeOOH, followed by reactions of α-Fe₂O₃ with BaCO₃ and BaFe₂O₄. The crystallinity of α-Fe₂O₃ and BaCO₃ from precursor α was better than from precursor γ due to the direct dehydroxylation of α-FeOOH, resulting in a lower nucleation rate and better crystallinity of BaFe₂O₄. BaFe₁₂O₁₉ prepared from precursor α showed lower crystallinity and purity with a higher length-diameter ratio than from precursor γ. The VSM results proved that the appearance of final products had an important influence on magnetic properties.     

Radon-Nikodym theorem in signed Loeb space

This paper gives the Radon-Nikodym theorem in signed Loeb space under 1-saturated nonstandard model. First,the nonstandard characterization of absolute continuity is discussed,on which Radon-Nikodym theorem in signed Loeb space is obtained. Then,some facts about a finite signed Loeb measure and its variation are shown.     

Birds of a Feather Protest Together: Theorizing Self-Organizing Political Protests with Flock Theory

The current research theorizes decentralized and self-organized political protests via flock theory (Rosen 2002), a theory of emergent self-organization in communicative human interaction. Flock theory draws from a theoretical basis of emergence and self-organizing systems, and is presented as a theory of decentralized communication structures. Focusing on the optimization of decentralized networks and roadmap based coordination of organizationally homopholous foci; the current theory poses a model of human interaction that captures the potentially egalitarian effects of cooperative evolution and collective action. Case studies of two separate decentralized political protests against Korean government and FARC are offered as evidences of such phenomena.     

Effect of intermittent aeration on the treatment performance in a submerged membrane bioreactor

In order to improve removal for nitrogen in a pilot-scale submerged membrane bioreactor (SMBR), intermittent aeration was conducted, and the effect on the treatment performance under four kinds of operation condition (run 1, continuous aeration; run 2, 60/60 min aeration on/off time; run 3, 60/90 min aeration on/off time; run 4, 60/75 min aeration on/off time) was evaluated. The results showed that depending on the specific on/off of the aeration time ratio, removal efficiency of nitrogen could be improved significantly, and the removal rates of total nitrogen (TN) under different operation conditions were 28.0%, 59.5%, 66.8% and 70.7%, respectively. There were no obvious differences for removal rates for COD_Cr and ammonia among different operation conditions. In general, intermittent aeration could be used as a feasible way to improve treatment performance for nitrogen in the SMBR.     

Viability criteria for differential inclusions

A method of verifying the viability criterion at a given point for a region with nonsmooth boundary, which is expressed by a quasidifferentiabl function, under a differential inclusion which is a convex hull of finitely many functions, is proposed. By this method, determining the viability is transformed into solving a number of systems of linear inequalities, or equivalently solving a number of linear programming problems. For the other differential inclusion, called the generalized convex process, it is shown that viability condition holds for a polytope if and only if it holds at all of its vertices. This result is an extension of corresponding one for a linear control system.