基于维基语义的多文档文摘研究

多文档文摘作为自然语言处理领域的重要技术之一,能从不同角度辅助用户实现高效的信息获取.由于文档集合内的内容往往来自不同的信息源,文本之间通常存在丰富而复杂的语义关系.常用的基于词的文档表示法,难以为文摘的语义分析过程提供充足而准确的数据信息.为此,我们提出使用维基百科——当今世界最大的在线概念语料库——为多文档文摘的提取提供语义支持.一方面,我们通过提取文档中的维基概念,生成准确一致的句子表示形式.另一方面,在计算句子特征时,我们利用维基词条的首段指导机器文摘的提取.我们首先通过计算概念在维基中的全局相关性和当前文档集内的局部相关性,获取概念的权重.然后在维基概念表示的基础上,为文档中的句子提取多种基于维基的特征,并最后用于文摘生成.在实验中,我们依次用各个维基特征独立生成文摘,并使用ROUGE(Recall-Oriented Understudy for Gisting Evaluation,面向召回率的要点评估)指标评价文摘质量.通过比较,实验验证了维基词条首段能较好的提升文摘质量.     

The ribosome uses two active mechanisms to unwind messenger RNA during translation

The ribosome translates the genetic information encoded in messenger RNA into protein. Folded structures in the coding region of an mRNA represent a kinetic barrier that lowers the peptide elongation rate, as the ribosome must disrupt structures it encounters in the mRNA at its entry site to allow translocation to the next codon. Such structures are exploited by the cell to create diverse strategies for translation regulation, such as programmed frameshifting, the modulation of protein expression levels, ribosome localization and co-translational protein folding. Although strand separation activity is inherent to the ribosome, requiring no exogenous helicases, its mechanism is still unknown. Here, using a single-molecule optical tweezers assay on mRNA hairpins, we find that the translation rate of identical codons at the decoding centre is greatly influenced by the GC content of folded structures at the mRNA entry site. Furthermore, force applied to the ends of the hairpin to favour its unfolding significantly speeds translation. Quantitative analysis of the force dependence of its helicase activity reveals that the ribosome, unlike previously studied helicases, uses two distinct active mechanisms to unwind mRNA structure: it destabilizes the helical junction at the mRNA entry site by biasing its thermal fluctuations towards the open state, increasing the probability of the ribosome translocating unhindered; and it mechanically pulls apart the mRNA single strands of the closed junction during the conformational changes that accompany ribosome translocation. The second of these mechanisms ensures a minimal basal rate of translation in the cell; specialized, mechanically stable structures are required to stall the ribosome temporarily. Our results establish a quantitative mechanical basis for understanding the mechanism of regulation of the elongation rate of translation by structured mRNAs.     

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

Epithelial integrity in metazoan organs is maintained through the regulated proliferation and differentiation of organ-specific stem and progenitor cells. Although the epithelia of organs such as the intestine regenerate constantly and thus remain continuously proliferative, other organs, such as the mammalian urinary bladder, shift from near-quiescence to a highly proliferative state in response to epithelial injury. The cellular and molecular mechanisms underlying this injury-induced mode of regenerative response are poorly defined. Here we show in mice that the proliferative response to bacterial infection or chemical injury within the bladder is regulated by signal feedback between basal cells of the urothelium and the stromal cells that underlie them. We demonstrate that these basal cells include stem cells capable of regenerating all cell types within the urothelium, and are marked by expression of the secreted protein signal Sonic hedgehog (Shh). On injury, Shh expression in these basal cells increases and elicits increased stromal expression of Wnt protein signals, which in turn stimulate the proliferation of both urothelial and stromal cells. The heightened activity of this signal feedback circuit and the associated increase in cell proliferation appear to be required for restoration of urothelial function and, in the case of bacterial injury, may help clear and prevent further spread of infection. Our findings provide a conceptual framework for injury-induced epithelial regeneration in endodermal organs, and may provide a basis for understanding the roles of signalling pathways in cancer growth and metastasis.     

体育比赛终点运动图像数字处理技术的研究

在竞技体育比赛中,运动成绩的确认,靠已往的手工计时无法满足要求,根据国际田联的规定,大型体育赛会都要求采用电动终点计时系统.目前,国内的研制水平仍然停留在黑白图像判定水平上,本文将高速彩色线阵CCD技术应用于径赛终点电动计时系统,对彩色图像采集后期处理中影响图像质量的各种因素进行了深入地分析,详尽描述了在数字图像处理中如何运用灰度、彩色平衡、直方图均衡化等数字图像处理技术,得到清晰的、高质量的彩色图像数据.     

基于幂函数控制指令的垂直飞行仿真性能分析

基于模态直接切换的飞行高度控制方法,在输入控制指令后,存在控制量输出震荡,甚至发散的问题。幂函数符合飞行高度指令变化规律,以此为原型函数,推导给定高度,当前高度和垂直速度之间的关系,将这一变换关系作为垂直速度控制回路的输入指令,设计了平稳控制系统,该系统不需要进行控制模态切换,就可以实现飞行高度保持,以及飞行高度的改变。通过A320飞行仿真平台对设计的平稳控制系统进行性能分析,结果表明该系统可以实现高度的平稳控制,且稳态误差得到了很好抑制。     

知识库系统的知识表示方法及其在移动学习领域的应用

本文主要讨论的问题是知识表示,探讨关于不同知识类型、知识表示发展的不同阶段,所运用的知识表示方式.以及联系现在与计算机技术相关的无线通讯技术,来探讨知识库系统在教育领域发展趋势.     

1961-2014年西安市秋淋气候特征分析

利用1961-2014年8-10月西安市7个气象站逐日降水资料,采用降水强度指数分析了西安市秋淋天气气候变化特征.结果表明,20世纪90年代是近50年来西安市秋季9~10月降水量最少的阶段.1961年以来西安市共有23 a出现秋淋多雨时段,20世纪60年代至80年代中期较多,1983年和1984年出现强秋淋;20世纪80年代中期至21世纪10年代初期,只有1992年出现了1次秋淋天气;2011年以来,秋淋呈明显上升、增强趋势.1961-2014年秋淋天气过程平均降水量呈上升趋势,偏多年份主要出现在20世纪80年代初中期和21世纪.厄尔尼诺使秋季9~10月降水量减少,与秋淋天气存在明显的负相关关系.近54年西安市秋淋没有发生显著的气候突变,存在4~6 a、10 a和24 a左右的长振荡周期.     

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.     

移动拟合法在煤层界面插值中的应用研究

为了在构建三维矿床模型过程中,形成最佳逼近的煤层界面模型,将移动拟合法引入到煤层界面插值中。根据煤层的赋存条件以及原始采样数据的分布特点提出了参数优化选择的有效方法及适用条件,并通过数学方法改善病态矩阵,使待估区域中的插值结果精度更高。以某矿的煤层界面数据为样本,通过交叉检验确定权函数,进行空间插值以及三维可视化,比较真实地反映了矿床的基本特征,为矿床地质模型的建立提供了有力的数据支撑。     

基于共形阵的角度和极化信息联合估计算法

针对复杂载体上共形阵列存在多极化接收和遮挡效应的问题,本文提出一种基于方向图矩阵重构导向矢量的改进极化多重信号分类(multiple signal classification, MUSIC)算法。首先对共形天线阵列进行建模,在获取各个阵元的方位和俯仰分量方向图数据后,将方向图数据分解并重构阵列的导向矢量矩阵,最后结合极化MUSIC算法进行波达方向(direction of arrival, DOA)和极化参数联合估计。相对于理论导向矢量的极化MUSIC算法,本文所提改进算法在解决了遮挡效应的同时具有更高的估计精度,并可有效降低运算量。仿真实验结果验证了这一结论。