拟终鞅

本文引入并讨论拟终鞅序列,关于鞅和终鞅的一些基本结果被明显地改进。     

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Tumour-associated ligands of the activating NKG2D (natural killer group 2, member D; also called KLRK1) receptor-which are induced by genotoxic or cellular stress-trigger activation of natural killer cells and co-stimulation of effector T cells, and may thus promote resistance to cancer. However, many progressing tumours in humans counter this anti-tumour activity by shedding the soluble major histocompatibility complex class-I-related ligand MICA, which induces internalization and degradation of NKG2D and stimulates population expansions of normally rare NKG2D+CD4+ T cells with negative regulatory functions. Here we show that on the surface of tumour cells, MICA associates with endoplasmic reticulum protein 5 (ERp5; also called PDIA6 or P5), which, similar to protein disulphide isomerase, usually assists in the folding of nascent proteins inside cells. Pharmacological inhibition of thioreductase activity and ERp5 gene silencing revealed that cell-surface ERp5 function is required for MICA shedding. ERp5 and membrane-anchored MICA form transitory mixed disulphide complexes from which soluble MICA is released after proteolytic cleavage near the cell membrane. Reduction of the seemingly inaccessible disulphide bond in the membrane-proximal alpha3 domain of MICA must involve a large conformational change that enables proteolytic cleavage. These results uncover a molecular mechanism whereby domain-specific deconstruction regulates MICA protein shedding, thereby promoting tumour immune evasion, and identify surface ERp5 as a strategic target for therapeutic intervention.     

A Message-Level Security Model Consisting of Multiple Security-Tokens Mechanism

0 Introduction Because of the advantage of Web service, the quick expansion of Web service in the Internet will cause more data and applications exposure to hackers and informa- tion burglars, so the information security threat that business enterprise fa…     

一种内疏水型透水混凝土的研制

将疏水剂引入透水混凝土中,研制一种内疏水型透水混凝土.采用正交试验,以28 d抗压强度和透水系数为试验指标,研究孔隙率、水灰比、疏水剂种类3个因素及不同水平对内疏水型透水混凝土性能的影响;通过极差分析及综合平衡法,分析各因素影响的主次关系,得出最优方案为孔隙率20%,水灰比0.28,荷叶疏水剂;通过对比试验可知,在最优方案下,掺入4%疏水剂较不掺入疏水剂混凝土强度提高28.9%.     

柴油机缸内机油消耗量的仿真计算及影响因素分析

为了降低发动机的机油消耗量,分析了发动机缸内机油消耗的4种主要模式,并以某柴油机为例,通过仿真的方法对某些常用工况下这4种模式的机油消耗量进行了计算,发现其中缸壁蒸发的机油量占了大部分.然后分析了柴油机不同运行工况、第2道活塞环闭口间隙及各道活塞环切向弹力对机油消耗的4种模式的影响规律.结果表明,缸壁蒸发量主要由发动机运行工况决定;第2道环闭口间隙的增大会降低顶环开口窜油量和增大漏气量;活塞环弹力的增加会减小剩余油膜厚度,进而降低顶环甩油及活塞顶刮油量,但同时会增大活塞环与缸套之间的摩擦损失.最后进行了柴油机台架机油消耗量实验,一定程度上验证了仿真计算结果的正确性.