基于中间件的企业应用集成

在企业的信息化发展过程中，形成的信息孤岛已成为现代企业信息共享的一个制约因素。笔者对当前企业应用集成的现状、方法及存在的问题进行了分析和讨论，通过结合中间件技术和Web技术特点，探讨了一个基于中间件技术的企业应用集成框架。该集成框架以中间件系统为核心构建分布式应用平台，克服了传统应用集成方法的不足，有效地解决了企业内部的跨平台应用间的集成问题，并为企业发展电子商务提供支持。     

Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system

The human adenovirus type 5 E1A, a tumor- suppressor gene[1], codes for two major related proteins of 243 amino acids (12S) and 289 amino acids (13S) by al-ternative splicing in two exons[2]. Studies have been shown that E1A can regulate expression of many genes and cell cycle[3]. Both in vitro and in vivo experiments indicated that E1A could induce tumor cells differentia-tion, convert tumor cells into an epithelial phenotype, in-hibit tumor cell growth and metastasis and strongly en-ha…     

空气水两相段塞流的跟踪模拟及试验研究

分析了前人提出的段塞跟踪模拟方法的优缺点 ,根据液塞头部的加速压降和入口液塞长度分布特征对段塞跟踪模型进行了改进。采用面向对象技术 ,实现了水平和倾斜管道段塞流的跟踪模拟 ,并与多相流试验环道的空气水试验数据进行了对比。模拟结果表明 ,当不考虑加速压降时 ,用跟踪模型预测的压降低于实测值 ;当考虑加速压降时 ,用跟踪模型预测的压降高于实测值。在管道上固定位置测出的压力信号符合正态分布 ,管道上某一固定点处液塞头部和尾部的速度分布也符合正态分布。当不考虑气泡尾波作用时 ,液塞长度沿管线增长较慢 ,分布形状无变化 ;但是考虑气泡尾波作用时 ,在入口附近液塞长度平均值增长较快 ,统计分布沿管轴向呈对数正态分布。     

在系统可编程模拟器件在智能雷预处理电路中的应用

在系统可编程模拟器件是近期出现的新型可编程模拟器件，它的问世将在系统可编程技术的应用由数字电路领域拓展至模拟电路领域。介绍了在系统可编程模拟器件的结构特点和工作原理，并利用isp—PAC10设计出智能雷探测系统的预处理电路。仿真结果表明，采用ispPAC10设计的预处理电路频率特性比较理想，系统的稳定性与可靠性高。ispPAC还可反复编程，电路修改方便。     

舟桥丙丁接头接触分析的计算机模拟

深入考察接触行为的特点，并以舟桥纵向连接件丙丁接头为例，建立了两种接触计算模型。采用大型通用有限元程序进行分析，模拟丙丁接头受力时的应力应变。与经验合成计算结果和常规有限元分析的结果进行对比，证明接触分析方法对连接件塑性变形、疲劳分析和优化设计有重要的指导意义。     

数字化天气雷达强度标定方法

数字化天气雷达的组网观测是天气雷达发展的必然趋势，现有数字化天气雷达提供的强度场必须经过强度标定后再用于组网，因此迫切要求制定数字化天气雷达标定方法。指出了使用标定方程时应注意的量纲问题，针对有关文献中存在的问题提出了解决方法。     

TiCl2-NH3·H2O液体发烟剂红外衰减性能实验

烟幕技术是现代战场效费比最高的光电对抗手段，其干扰效果依赖于烟幕的组成成分。对基于四氯化钛-氨水体系液体发烟剂布设的烟幕的红外衰减性能进行了研究，发现在适宜条件下，烟雾呈中性，同时对3～5μm和8～12μm红外辐射的衰减率可分别达到65％和90％。当靶温在34℃～73℃之间变化时，烟幕对8～12μm红外辐射的衰减率均高于90％，对3～5μm红外辐射的衰减率随靶温升高而降低。     

Evolution of the South China Sea and monsoon history revealed in deep-sea records

As the third summary report of ODP Leg 184 to the South China Sea (SCS), this paper discusses the evolution of the East Asian monsoon and the SCS basin. A multi-proxy approach, involving geochemistry, micropale-ontology, pollen and other analyses, was adopted for reconstructing the evolutionary history of the East Asian monsoon, which was characterized by a series of paleo-climate events especially at 8, 3.2, 2.2 and 0.4 Ma. The new record indicates similar stages in the development of the East and South Asian monsoons, with an enhanced winter monsoon over East Asia being the major difference. The rich spectrums of monsoon variability from the southern SCS also reveal other characteristic features of the low latitude ocean. Evidence for the evolution of the SCS includes the hemipelagic Oligocene sediments, implying the existence of deep water environments during the early seafloor spreading stage of the SCS basin. The four major unconformities and some remarkabl ediagenetic features in upper Oligocene deposits indicate the strongest tectonic events in the region. From a careful comparison of lithologies and sedimentation rates, we conclude that the prominent differences in sedimentary environments between the southern and northern SCS were established only by ～3 Ma.     

Inhibitory effect of the adenovirus type 5 E1A protein expressed in the yeast system of the human tumor cell growth

Adenovirus 5 type E1A as a tumor suppressor gene can inhibit tumor growth and enhance the censitivity of chemotherapy and radiotherapy.E1A have the ability to integrate into the host genome,resulting in long-time expres-sion that induces Rb gene inactivation and animal cells im-mortalization.This prompted us to select the E1A protein for treatment of cancer in order to overcome the limitations of E1A gene therapy.Thus,we firstly comstructed E1A eu-caryotic expression vector (pPIC9/E1A),transformated the pichia pastoris yeast cells(GS115) and screened the high-expressing recombinant strains.The positive yeast strains were cultured in the shake flask,and induced for 3d.The crude E1A protein was purified using two steps of col-umu chromatography on HiTrap Q and HiTrap SP.The pu-rified E1A protein was identified by SDS-PAGE and Western blot.E1A protein was mostly located at cellular unclear when Cheriot delivered E1A protein into cells.The analysis in vitro indicated that the E1A protein arrested LN686 cell cycle at G2/M phase,and significantly inhibited the growth of LN686 tumor cells.The current studies firstly provided an experimental basis to further develop E1A protein for tumor treatment.     

改变水分子簇的结构及诱发的生物效应研究

概述了水分子簇理论研究的基本状况,以及改变水分子团簇结构的4种方法,包括外加磁场、外加电场、激光辐射以及直接加热法;最后简要介绍了改变水分子团簇结构所诱发的生物效应.