Fe(CN)_6~(3-/4-)在铂电极上氧化还原过程的表面拉曼光谱研究(英文)

本文运用共聚焦显微拉曼仪结合特殊的电极表面粗糙方法首次获得了Fe(CN)_6~(3-/4-)在铂电极表面氧化还原过程的拉曼光谱图。研究结果表明Fe(CN)_6~(3-)在电极表面的吸附能力比Fe(CN)~(4-)强,它们都是通过CN上的N原子和电极表面成键而发生化学吸附的。     

钢板-砼组合加固钢筋砼梁的研究及应用进展

钢板-混凝土组合加固技术是钢筋混凝土梁加固的一种的新方法.简介了目前关于钢板-混凝土组合加固梁抗弯和抗剪承载力研究的成果,分析考虑界面滑移、二次受力等因素对于承载能力影响的研究现状,探讨了该加固技术试验研究方法及工程应用情况.通过对现有研究成果的归纳和总结,分析了该技术的主要特点与不足,并指出了有关钢板-混凝土组合加固方面值得进一步研究的问题.     

缺帧环境下遮挡图像的特征优化提取方法研究

针对缺帧环境下图像的遮挡问题,提出一种新的特征优化提取方法。建立缺帧环境下遮挡图像采集模型,在此基础上,利用正方形网格建立立体模型,实现图像采集。通过阈值降噪法完成对遮挡图像的降噪滤波处理。DCS-LBP算子通过梯度方向上变化的灰度值实现编码,效果不佳,通过GCS-LDP算子对其进行优化,将二者结合在一起对缺帧环境下遮挡图像施行编码,获取最后的直方图,将该直方图看作遮挡图像的特征,完成遮挡图像特征的优化提取。实验结果表明,所提方法能够有效对缺帧环境下遮挡图像进行预处理,且识别效率高,计算量少。     

Protein arginine deiminase 4: a target for an epigenetic cancer therapy

The recent approvals of anticancer therapeutic agents targeting the histone deacetylases and DNA methyltransferases have highlighted the important role that epigenetics plays in human diseases, and suggested that the factors controlling gene expression are novel drug targets. Protein arginine deiminase 4 (PAD4) is one such target because its effects on gene expression parallel those observed for the histone deacetylases. We demonstrated that F- and Cl-amidine, two potent PAD4 inhibitors, display micromolar cytotoxic effects towards several cancerous cell lines (HL-60, MCF7 and HT-29); no effect was observed in noncancerous lines (NIH 3T3 and HL-60 granulocytes). These compounds also induced the differentiation of HL-60 and HT29 cells. Finally, these compounds synergistically potentiated the cell killing effects of doxorubicin. Taken together, these findings suggest PAD4 inhibition as a novel epigenetic approach for the treatment of cancer, and suggest that F- and Cl-amidine are candidate therapeutic agents for this disease.     

A Note on the Property of ψ-Function

About the accurate value of ψ ( x ) = Γ′ ( x ) / Γ ( x), we know only ψ (1)and ψ (1/ 2).In this paper, by calculating the accurate values of some series expansion of a function and applying some skills of complex analysis, we prove that the expression of the ψ-function admits a finite expression in elementary function for rational number z. As an application, some examples are given.     

构造裂隙对巷道稳定性影响的评价方法

地下岩石工程中，构造裂隙分布状况与发育程度对巷道的稳定性影响很大。结合潞安矿区3个矿井的构造理解隙实测结果，提出裂隙因素巷道稳定性的评价方法，为裂隙岩体巷道稳定性的定量化评价奠定了基础。     

2000年问题与计算机教学

2000年问题说到底是在把资源无限的人脑中的数字转换到资源有限的计算机系统中的数字时使用方法不当而造成的问题,因而并不是一个特别的问题,而是一个普遍的问题。本文试图从教学的角度讨论怎样教好学生从本质上认清计算机系统中的信息、特别是数字的定义和处理,使学生能更加深刻地理解计算机和计算机系统,避免在今后的工作中再犯类似2000年的问题的错误。     

高稳定度电源设计的关键因素

通过传递函数，从7个方面系统分析了影响电源高稳定度的各种因素，讨论了电源基本参数及它们之间的关系，得出影响电源稳定度的直接因素是基准电压的稳定度、分流器阻值随温度的变化、放大器输入端电压的漂移，间接因素是放大器本身参数的变化、放大器输入端内阻漂移、负载电阻随温度的变化、交通电网的波动以便为研制和设计高稳定度电源提供理论依据。     

X线双能量骨密度仪模拟研究

双能量Ｘ线吸收骨密度测量仪是对骨质疏松症进行诊治的重要手段。由于Ｘ线源通常具有一个较宽的能谱，因而骨密度测量值的计算比较复杂。对如何在仪器研制中获得足够高的测量精度问题，本文进行了详细的计算机模拟工作，给出了模拟计算的方法及定量的结果。     

The role of endosomal-recycling in long-term potentiation

Long-term potentiation (LTP) defines persistent increases in neurotransmission strength at synapses that are triggered by specific patterns of neuronal activity. LTP, the most widely accepted molecular model for learning, is best characterised at glutamatergic synapses on dendritic spines. In this context, LTP involves increases in dendritic spine size and the insertion of glutamate receptors into the post-synaptic spine membrane, which together boost post-synaptic responsiveness to neurotransmitters. In dendrites, the material required for LTP is sourced from an organelle termed the endosomal-recycling compartment (ERC), which is localised to the base of dendritic spines. When LTP is induced, material derived from the recycling compartment, which contains α-amino-3-hydroxy-5-methyl-4-isoxazole propionate-type glutamate receptors (AMPARs), is mobilised into dendritic spines feeding the increased need for receptors and membrane at the spine neck and head. In this review, we discuss the importance of endosomal-recycling and the role of key proteins which control these processes in the context of LTP.