浅谈新时期雷锋精神

雷锋精神在神州大地上熠熠生辉已整整40年。雷锋精神对当今社会仍有着积极的现实意义,其意义体现为“八性”,即：民族性、时代性、实践性、群众性、统一性、一致性、国际性与文学性。     

Notch1 functions as a tumor suppressor in mouse skin

Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is associated with tumorigenesis. The role of Notch signaling in mammalian skin is less well characterized and is mainly based on in vitro studies, which suggest that Notch signaling induces differentiation in mammalian skin. Conventional gene targeting is not applicable to establishing the role of Notch receptors or ligands in the skin because Notch1-/- embryos die during gestation. Therefore, we used a tissue-specific inducible gene-targeting approach to study the physiological role of the Notch1 receptor in the mouse epidermis and the corneal epithelium of adult mice. Unexpectedly, ablation of Notch1 results in epidermal and corneal hyperplasia followed by the development of skin tumors and facilitated chemical-induced skin carcinogenesis. Notch1 deficiency in skin and in primary keratinocytes results in increased and sustained expression of Gli2, causing the development of basal-cell carcinoma-like tumors. Furthermore, Notch1 inactivation in the epidermis results in derepressed beta-catenin signaling in cells that should normally undergo differentiation. Enhanced beta-catenin signaling can be reversed by re-introduction of a dominant active form of the Notch1 receptor. This leads to a reduction in the signaling-competent pool of beta-catenin, indicating that Notch1 can inhibit beta-catenin-mediated signaling. Our results indicate that Notch1 functions as a tumor-suppressor gene in mammalian skin.     

CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

To maintain genome stability, DNA replication is strictly regulated to occur only once per cell cycle. In eukaryotes, the presence of 'licensing proteins' at replication origins during the G1 cell-cycle phase allows the formation of the pre-replicative complex. The removal of licensing proteins from chromatin during the S phase ensures that origins fire only once per cell cycle. Here we show that the CUL-4 ubiquitin ligase temporally restricts DNA-replication licensing in Caenorhabditis elegans. Inactivation of CUL-4 causes massive DNA re-replication, producing cells with up to 100C DNA content. The C. elegans orthologue of the replication-licensing factor Cdt1 (refs 2, 3) is required for DNA replication. C. elegans CDT-1 is present in G1-phase nuclei but disappears as cells enter S phase. In cells lacking CUL-4, CDT-1 levels fail to decrease during S phase and instead remain constant in the re-replicating cells. Removal of one genomic copy of cdt-1 suppresses the cul-4 re-replication phenotype. We propose that CUL-4 prevents aberrant re-initiation of DNA replication, at least in part, by facilitating the degradation of CDT-1.     

杨树不同杂交组合苗期性状遗传变异

对T120×S3107等8个杂交组合及各组合内无性系间的苗高、胸径、分枝情况等性状变异进行了研究。结果表明,组合间和无性系间在各性状上存在着显著的变异,苗高、胸径、侧枝的广义遗传力分别为77.75%,52.64%,56.96%。各杂交组合苗高和胸径平均值均超过对照T120和I 69。I 69×S3244,I 69×I 63组合的苗高和胸径性状表现都较好。因此,从这批材料中选出优良无性系是有可能的。     

Coupling and feedback between iron and sulphur in air-sea exchange

Iron in surface seawater has been demonstrated to be the limiting nutrient factor for primary productivity in certain oceanic regions where other major nutrients are abundant[1—5]. The available Fe to the phytoplankton in seawater is related to the uptake of carbon dioxide through the ocean and, in turn, to the global greenhouse effect[6—11]. Recent reports showed that the available Fe in the seawater is closely correlative to nitrogen fixation in the ocean[12—17]. Understanding which Fe s…     

基于改进BP算法的刚框架连接损伤识别方法

运用权值、阈值同步学习BP算法(简称为改进BP算法)对钢框架连接损伤进行识别,并且选用由结构正则化的频率变化率和少数点的振型模态分量构成的组合参数作为网络输入参数.通过对一个4层钢框架数值模拟,比较了改进算法和传统算法测试结果,从而证明改进算法更加精确、优越.     

非比例阻尼隔震结构平扭耦联地震反应分析

根据非比例阻尼隔震结构的动力特性,提出了非比例阻尼隔震结构平扭耦联振动的运动方程.分析了地震作用下,非比例阻尼隔震结构平扭耦联振动反应,并讨论了隔震层和上部结构的偏心及质量偏心对结构动力响应的影响.     

异方差的检验比较和修正

异方差是计量经济工作中线性回归模型经常遇到的问题,异方差的存在对线性回归分析有很强的破坏作用.通过对异方差产生的原因和后果进行分析,利用异方差的戈德菲尔特-夸特检验、拉格朗日乘数(LM)检验、怀特检验方法,判断线性回归模型异方差的存在性.通过加权最小二乘法或可行广义最小二乘法进行修正,建立能够真正反映经济规律的经济模型,实现对经济的正确指导作用.     

数学建模在创新型人才培养中的作用

介绍了数学建模的发展及数学建模的思想方法,论述创新型人才的特征,阐述了数学建模教学与数学建模竞赛对培养创新型人才的作用,进行了工科数学教学及教学改革适应于创新型人才培养的研究与探讨.     

ω-超广义函数的卷积运算

讨论ω-超广义函数间中的卷积运算，并且给出了一些超广义函数卷积运算的公式。