Ca2+ release induced by inositol 1,4,5-trisphosphate is a steady-state phenomenon controlled by luminal Ca2+ in permeabilized cells.

Low concentrations of inositol 1,4,5-trisphosphate (InsP3) evoke a very rapid mobilization of intracellular Ca2+ stores in many cell types, which can be followed by a further, much slower efflux. Two explanations have been suggested for this biphasic release. The first proposes that the Ca2+ stores vary in their sensitivity to InsP3, and each store releases either its entire contents or nothing (all-or-none release); the second proposes instead that the stores are uniformly sensitive to the effects of InsP3, but that they can release only a fraction of their Ca2+ before their sensitivity is somehow attenuated (steady-state release). Experiments using purified InsP3 receptor molecules reconstituted into lipid vesicles have shown heterogeneity of the receptors in their response to InsP3 under conditions in which the total Ca2+ level at both sides of the receptor is held constant. We now report that in permeabilized A7r5 smooth-muscle cells incubated in Ca(2+)-free medium, the amount of 45Ca2+ remaining in the stores after the rapid transient phase of release is independent of their initial Ca2+ levels, indicating that partially depleted stores are less sensitive to InsP3. Moreover, if the stores are reloaded with 40Ca2+ after the first stimulus, reapplication of the same low concentration of InsP3 will release further 45Ca2+. This recovery of InsP3 sensitivity is almost complete. Under these conditions, Ca2+ release must thus occur by a steady-state mechanism, in which the decreasing Ca2+ content of the stores slows down further release.     

聚醚型脂肪族聚氨酯预聚体的制备

以ＨＤＩ为异氰酸酯组分，制备聚醚型脂肪族聚氨酯预聚体。对聚醚脱水条件，反应温度和时间，以及预聚体的一些性能进行了探索。     

Resistant orthogonal procrustes analysis

In this paper two alternative loss criteria for the least squares Procrustes problem are studied. These alternative criteria are based on the Huber function and on the more radical biweight function, which are designed to be resistant to outliers. Using iterative majorization it is shown how a convergent reweighted least squares algorithm can be developed. In asimulation study it turns out that the proposed methods perform well over a specific range of contamination. When a uniform dilation factor is included, mixed results are obtained. The methods also yield a set of weights that can be used for diagnostic purposes.     

矩阵极坐标的应用

该文应用矩阵极坐标方法,对文献[1]中出现的几个重要定积分作了重新处理,并运用古典的Andreief-Stieltjes公式,将其复杂的多维定积分化为简单的行列式计算。所得结果,结构简单,计算方便。     

环氧乙烷四氢呋喃共聚醚[P(E-CO-T)]的研制

研究了环氧乙烷与四氢呋喃的共聚.使用BF_3络合物为催化剂,1,4-丁二醇为共催化剂.找到了溶液聚合和本体聚合适宜的工艺条件.在此条件下,环齐聚物的生成量为8％左右.找到了方便易行的纯化方法,通过纯化可把聚醚的环齐聚物含量降到1％以下,有效地提高了产品的质量。     

非马尔科夫多值噪声驱动下系统的平均第一通过时间

本文把Weiss等发展的计算平均第一通过时间(简称MFPT)的新方法推广到由非马尔科夫多值噪声驱动的过程.为了简化,本文只限于研究矩形分布这一情形.通过一个重要实例,对MFPT进行了具体计算,并得到了显式解析表示.     

再议网络图的逻辑同构变换

图对同一个逻辑问题可有不同的表达方式，在必要时需进行逻辑同构变换＾［１］。本文对“节点型网络向箭线型网络的逻辑风构变换”的研究进行了补充，增加了三种情况的图开有子模，进一步谁了逐节生长法的通用性。同时，提出了箭线型网络向节点型网络逆向变换的算法；逐线收缩法。     

用付里叶—菲涅耳全息图做光学相减和光学微分

提出一种进行光学相减和学学微分的新方法,对离焦象与准确象的差即为物体图象的二阶微分做了证明.实验结果与理论分析吻合