全文获取类型
收费全文 | 3328篇 |
免费 | 73篇 |
国内免费 | 14篇 |
专业分类
系统科学 | 120篇 |
丛书文集 | 3篇 |
教育与普及 | 2篇 |
理论与方法论 | 26篇 |
现状及发展 | 1005篇 |
研究方法 | 44篇 |
综合类 | 2198篇 |
自然研究 | 17篇 |
出版年
2024年 | 21篇 |
2023年 | 27篇 |
2022年 | 9篇 |
2020年 | 12篇 |
2017年 | 9篇 |
2016年 | 31篇 |
2015年 | 56篇 |
2014年 | 26篇 |
2013年 | 22篇 |
2012年 | 148篇 |
2011年 | 169篇 |
2008年 | 12篇 |
2007年 | 12篇 |
2006年 | 26篇 |
2005年 | 236篇 |
2004年 | 534篇 |
2003年 | 499篇 |
2002年 | 164篇 |
2001年 | 76篇 |
2000年 | 138篇 |
1999年 | 76篇 |
1992年 | 37篇 |
1991年 | 25篇 |
1990年 | 35篇 |
1989年 | 34篇 |
1988年 | 32篇 |
1987年 | 16篇 |
1986年 | 26篇 |
1985年 | 35篇 |
1984年 | 26篇 |
1983年 | 24篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1980年 | 16篇 |
1979年 | 61篇 |
1978年 | 39篇 |
1977年 | 30篇 |
1976年 | 29篇 |
1975年 | 38篇 |
1974年 | 56篇 |
1973年 | 49篇 |
1972年 | 50篇 |
1971年 | 66篇 |
1970年 | 54篇 |
1969年 | 68篇 |
1968年 | 59篇 |
1967年 | 41篇 |
1966年 | 55篇 |
1965年 | 41篇 |
1964年 | 11篇 |
排序方式: 共有3415条查询结果,搜索用时 0 毫秒
61.
62.
In 1873, W. K. Clifford introduced a notion of parallelism in the three-dimensional elliptic space that, quite surprisingly, exhibits almost all properties of Euclidean parallelism in ordinary space. The purpose of this paper is to describe the genesis of this notion in Clifford’s works and to provide a historical analysis of its reception in the investigations of F. Klein, L. Bianchi, G. Fubini, and E. Bortolotti. Special emphasis is placed upon the important role that Clifford’s parallelism played in the development of the theory of connections. 相似文献
63.
Altenhöfer S Kleikers PW Radermacher KA Scheurer P Rob Hermans JJ Schiffers P Ho H Wingler K Schmidt HH 《Cellular and molecular life sciences : CMLS》2012,69(14):2327-2343
Reactive oxygen species (ROS) are cellular signals but also disease triggers; their relative excess (oxidative stress) or shortage (reductive stress) compared to reducing equivalents are potentially deleterious. This may explain why antioxidants fail to combat diseases that correlate with oxidative stress. Instead, targeting of disease-relevant enzymatic ROS sources that leaves physiological ROS signaling unaffected may be more beneficial. NADPH oxidases are the only known enzyme family with the sole function to produce ROS. Of the catalytic NADPH oxidase subunits (NOX), NOX4 is the most widely distributed isoform. We provide here a critical review of the currently available experimental tools to assess the role of NOX and especially NOX4, i.e. knock-out mice, siRNAs, antibodies, and pharmacological inhibitors. We then focus on the characterization of the small molecule NADPH oxidase inhibitor, VAS2870, in vitro and in vivo, its specificity, selectivity, and possible mechanism of action. Finally, we discuss the validation of NOX4 as a potential therapeutic target for indications including stroke, heart failure, and fibrosis. 相似文献
64.
65.
66.
Age is an important risk for autoimmunity, and many autoimmune diseases preferentially occur in the second half of adulthood
when immune competence has declined and thymic T cell generation has ceased. Many tolerance checkpoints have to fail for an
autoimmune disease to develop, and several of those are susceptible to the immune aging process. Homeostatic T cell proliferation
which is mainly responsible for T cell replenishment during adulthood can lead to the selection of T cells with increased
affinity to self- or neoantigens and enhanced growth and survival properties. These cells can acquire a memory-like phenotype,
in particular under lymphopenic conditions. Accumulation of end-differentiated effector T cells, either specific for self-antigen
or for latent viruses, have a low activation threshold due to the expression of signaling and regulatory molecules and generate
an inflammatory environment with their ability to be cytotoxic and to produce excessive amounts of cytokines and thereby inducing
or amplifying autoimmune responses. 相似文献
67.
Over the last two decades the molecular and cellular mechanisms underlying T cell activation, expansion, differentiation,
and memory formation have been intensively investigated. These studies revealed that the generation of memory T cells is critically
impacted by a number of factors, including the magnitude of the inflammatory response and cytokine production, the type of
dendritic cell [DC] that presents the pathogen derived antigen, their maturation status, and the concomitant provision of
costimulation. Nevertheless, the primary stimulus leading to T cell activation is generated through the T cell receptor [TCR]
following its engagement with a peptide MHC ligand [pMHC]. The purpose of this review is to highlight classical and recent
findings on how antigen recognition, the degree of TCR stimulation, and intracellular signal transduction pathways impact
the formation of effector and memory T cells. 相似文献
68.
Valiokas R 《Cellular and molecular life sciences : CMLS》2012,69(3):347-356
The actual progress towards biological chip devices consisting of nanostructured functional entities is summarized. The practical
aspects of molecular nanobiochips are discussed, including the main surface chemistry platforms, as well as conventional and
unconventional fabrication tools. Several successful biological demonstrations of the first generation of nanobiochip devices
(mainly, different nanoarrays) are highlighted with the aim of revealing the potential of this technology in life sciences,
medicine, and related areas. 相似文献
69.
Toll-like receptors (TLRs) are a class of pattern recognition receptors sensing microbial components and triggering an immune
response against pathogens. In addition to their role in anti-infection immunity, increasing evidence indicates that engagement
of TLRs can promote cancer cell survival and proliferation, induce tumor immune evasion, and enhance tumor metastasis and
chemoresistance. Recent studies have demonstrated that endogenous molecules or damage-associated molecular patterns released
from damaged/necrotic tissues are capable of activating TLRs and that the endogenous ligands-mediated TLR signaling is implicated
in the tumor development and affects the therapeutic efficacy of tumors. Since both exogenous and endogenous TLR ligands can
initiate TLR signaling, which is the most valuable player in tumor development becomes an interesting question. Here, we summarize
the effect of TLR signaling on the development and progression of tumors, and discuss the role of exogenous and endogenous
TLR ligands in the tumorigenesis. 相似文献
70.