水－仲丁醇－碳4三元体系8MPa时的液液平衡

在国内首次建立的一套温度高达３５０℃，压力直至２０ＭＰａ的高压液液相平衡测定装置上，测定了水－仲丁醇－碳４三元体系在８ＭＰａ和４０３．１５，４２３．１５，４４３．１５Ｋ时液液相平衡数据。采用修改的Ｒ－Ｋ方程对此数据进行了理论关联。关联结果与实验数据一致。     

域D＝｛z＝（z_1，z_2）∈C~2：｜z_1｜＋｜z_2｜＜1｝的解析自同

给出了域Ｄ＝｛ｚ＝（ｚ＿１，ｚ＿２）∈Ｃ＿２：｜ｚ＿１｜＋｜ｚ＿２｜＜１｝上的Ｂｅｒｇｍａｎ核函数及其解析自同构最大群。     

高应变率扭转SHB实验技术

介绍自制分离式霍布金生扭杆试验设备；详细推导出按扭转ＳＨＢ方法测量材料的动态剪应力和剪应变关系的基本方程；对软铝进行高应变率试验得到动态剪应力和剪应变关系曲线。     

知识库的校验研究

以基于规则的知识表达方式为例，论述了知识库的完整性和一致性校验的内容和方法，给出了各种非确定性处理方法统一的抽象描述，研究了非确定性处理对校验的影响。一些结果已应用于自行设计的圈闭评价专家系统中。     

论民族国家文化建构与话语选择的三个维度

从20世纪50年代末开始,西方文化研究取得了快速的发展,最终在90年代形成了文化研究的高潮。结果,新文化的研究旨趣横扫了欧美大部分学术领域,取代了一度占据学术制高点的新社会学研究方法。从研究中可以看出,民族国家的文化不但是继承的、发展变化的还是针对现实问题而创造的。文化的创造性建构也是当今全球化现实的要求。在这一过程中,要求民族国家文化发展道路的选择上具有三个维度的渐进式发展和升华：社团话语、民族国家话语以及世界话语。     

Crystal structure of the β2 adrenergic receptor-Gs protein complex

G protein-coupled receptors (GPCRs) are responsible for the majority of cellular responses to hormones and neurotransmitters as well as the senses of sight, olfaction and taste. The paradigm of GPCR signalling is the activation of a heterotrimeric GTP binding protein (G protein) by an agonist-occupied receptor. The β(2) adrenergic receptor (β(2)AR) activation of Gs, the stimulatory G protein for adenylyl cyclase, has long been a model system for GPCR signalling. Here we present the crystal structure of the active state ternary complex composed of agonist-occupied monomeric β(2)AR and nucleotide-free Gs heterotrimer. The principal interactions between the β(2)AR and Gs involve the amino- and carboxy-terminal α-helices of Gs, with conformational changes propagating to the nucleotide-binding pocket. The largest conformational changes in the β(2)AR include a 14 ? outward movement at the cytoplasmic end of transmembrane segment 6 (TM6) and an α-helical extension of the cytoplasmic end of TM5. The most surprising observation is a major displacement of the α-helical domain of Gαs relative to the Ras-like GTPase domain. This crystal structure represents the first high-resolution view of transmembrane signalling by a GPCR.     

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide insights into inactive states of several GPCRs. Efforts to obtain an agonist-bound active-state GPCR structure have proven difficult due to the inherent instability of this state in the absence of a G protein. We generated a camelid antibody fragment (nanobody) to the human β(2) adrenergic receptor (β(2)AR) that exhibits G protein-like behaviour, and obtained an agonist-bound, active-state crystal structure of the receptor-nanobody complex. Comparison with the inactive β(2)AR structure reveals subtle changes in the binding pocket; however, these small changes are associated with an 11?? outward movement of the cytoplasmic end of transmembrane segment 6, and rearrangements of transmembrane segments 5 and 7 that are remarkably similar to those observed in opsin, an active form of rhodopsin. This structure provides insights into the process of agonist binding and activation.     

离散事件仿真的CPU缓存加速算法

针对大规模离散事件仿真的应用需求,提出了CPU(中央处理器)缓存加速算法。采用空间局域化的环型链表存储事件摘要,兼具离散事件仿真(DES)事件分类和缓存加速作用。算法性能分析显示,入队时间复杂度为O(sqrt(n)),出队复杂度为O(1),优于目前主流的日历调度算法及改进算法。100节点9 900并发业务的网络仿真实验结果证实,相比于线性链表算法,文中提出的算法可使DES计算加速21倍。     

己二酸绿色合成的教学实验研究

以30%H202为氧源,钨酸钠为催化剂,三辛基甲基硫酸氢铵为相转移催化剂催化氧化环己烯合成己二酸,在回流温度下,反应1 h,己二酸的分离产率(基于环己烯)为48.6%～68.6%.反应中微溶于水的季铵盐相转移剂和水溶性强的钨酸钠催化剂均可回收并重复利用.这是一条合成己二酸的典型绿色途径,克服了目前有机化学实验教材中采用的浓HN03或KMn04氧化法存在的污染大、反应时间长和后处理繁杂的缺点.     

无界问题自然边界元与有限元的迭代耦合

根据区域分解算法的思想,研究了自然边界元与有限元耦合法的D-N迭代原理,并编写了耦合法计算程序,求解了带方孔的无界平面弹性问题。算例计算结果表明:当计算半径R取为孔洞尺寸的1.2倍,耦合法网格划分时取144个节点即可较好的逼近收敛值,而相同收敛效果有限元网格划分时需取272个节点。并且,在迭代过程中,松弛因子的选取对迭代收敛速度的影响很大,当松弛因子取0.2时,迭代收敛速度最快。