SPM的数学基础及其在脑功能成像研究中的应用

探讨SPM的数学基础,给出了SPM中利用一般线性模型(General LinearModel,GLM)构建统计参数图的方法;为了适应处理功能磁共振成像(functionalMagnetic Resonance Imaging,fMR I)数据的需要,对一般线性模型做了扩展,推导出扩展的GLM的检验统计量和自由度.最后将扩展的一般线性模型应用于一个具体的fMR I实验,说明了方法的有效性.     

Stereo- and regio-selectivity in the photosensitized dimerization of 1, 3-dimethylthymine in solution

The effects of reaction pathway and temperature on stereo- and regio-selectivity of photocycloaddition of 1, 3-dimethylthymine (DMT) which gives four cyclobutane type dimers in solution using acetone as the photosensitizer, are investigated by measuring the product distribution. It is demonstrated that the ground-state aggregation between DMT molecules mainly leads to (h-t)dimers, and the diffusion-controlled triplet dimerization is favorable to the formation of (h-h) dimers.     

A template of rat brain based on fMRI T*2 imaging

The development of functional magnetic resonance imaging (fMRI) technology has made it possible to carry out functional brain imaging experiments in small animals. Usually, group data is required to form the assessment of population, which can not only increase the sensitivity of the overall experiment, but also allow the generalization of the conclusion to the whole population. In order to average the signals of functional brain images from different subjects, it is necessary to put all the mapping images into the same standard space (template image). However, up to now, most animal brain templates remain unavailable and it must be done by ourselves. In this study, a template image based on the brains of eight male Wistar rats is obtained, and it is successfully used in our present Alzheimer disease (AD)-like rat model studies as template for spatially normalizing images to the same stereotaxical space. The fMRI results processed with statistical parametric mapping (SPM99) software are in agreement with the results from immunohistochemical experiment, which proves that this method is universally applicable to the pathologic models of other small animals and to human brain lesion studies.     

逐步等效t检验最优值的修正及应用

给出了逐步生物等效t检验最大耐受剂量值的一个修正法，使用该法可以最大限度地提高药物耐受剂量水平的精度，并在概率1—α之下保证安全性，使得最优耐受剂量值最大限度地接近真实最大耐受剂量值。     

针刺老年大鼠"足三里"、"关元"穴对SOD、CAT、GSH-PX活性影响的实验研究

通过针刺老年大鼠“足三里”、“关元”穴^(1)观测大鼠脑、心、肾组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH—PX)活性的变化来探讨针刺与衰老的关系。采用生物化学方法检测针刺后大鼠组织内SOD、CAT、GSH—PX含量的变化。结果表明，针刺能提高脑、心、肾组织中SOD、CAT及GSH—PX活性。提示针刺老年大鼠“足三里”、“关元”穴区能提高氧化清除酶活性，抑制脂质过氧化反应，从而起到延缓衰老的进程，达到抗衰老作用。     

组织合作网与生产要素的流动

提出组织合作网的概念.由于传统的生产要素不合理,影响其流动,通过组建合作网,生产要素流动,资源重新配置,组织结构得以调整和优化,并得到创新,从而保持合作网的活力.合作网有个领头组织,由他带领使网内每个成员获利,创造出新的生产力.     

大跨度斜拉索输油管桥模型固有振动的实验研究

建立了大跨度斜拉索输油管桥模型实验的相似条件，并以某大跨度管桥为例，采用两种不同的边界条件，对某大跨度斜拉索输油管桥固有振动进行了模型实验，通过实验，测得到了管桥的前几阶自振频率并与有关计算结果进行了比较，比较结果验证了文中的实验方法的可靠性，提出的实验方法可以用于预报类似柔性结构体系的固有振动频率。     

程控一氧化碳报警器的设计

利用单片机控制技术,采用巡回检测的方法,设计制作了程控一氧化碳报警器.该仪器对一氧化碳(CO)进行实时监控,当一氧化碳的浓度超过允许值时,控制电路进行报警,并通过外接排风扇与电磁阀对其进行程控,以防事故的发生.     

2K-H双级串联式行星轮系的优化设计

文章按各级径向尺寸协调和外啮合接触强度相等的原则对双级2K-H型行星轮系的总传动比进行优化分配,从而将双级行星轮系的优化设计转变成单级行星轮系的优化设计。以太阳轮、行星轮和内齿圈体积之和最小作为优化目标建立了优化数学模型。应用复合形法求解数学模型择取最优参数方案。通过实例计算,取得了满意的结果。     

关于Pro/E2001用非闭合截面创建实体特征的探讨

文章探讨了Pro/E用非闭合截面创建实体特征的几种特定情况,通过实例介绍了创建这些实体特征的具体工作步骤,指明了不同特定情况用非闭合截面创建实体特征的本质区别以及注意事项。