河北省高校区域创新体系服务调查研究

高校是区域创新体系的重要主体要素。近年来,高校凭借其雄厚的科研基础和集聚的科研人才,迅速成为推动区域经济和社会发展的主要生长点和辐射源。研究通过对河北省高校为区域创新体系发展提供人才培养培训服务、平台服务和资源保障的实际情况,总结高校服务取得的成绩和存在的问题,并提出相关发展对策和建议。     

苯并[1，2-b：4，5-b’]二噻吩-thieno[3，4-易]thiadiazole导电性的理论研究

采用密度泛函理论，在B3LYP／6—31G（d）水平下，对苯并[1，2-b：4，5-b’]二噻吩（BDT）-thieno[3，4-b]thiadiaz01e（TD）的低聚物和聚合物进行了理论计算．其中，BDT为电子供体，TD为电子受体，以1：2的方式结合形成化合物，并计算了二面角、分子内的电荷传输、桥键键长和中心键电荷密度．结果显示：随着聚合链增长，共轭程度增加．NICSs值显示：中心环比边环的共轭程度更大．聚合物的能带结构表明：该聚合物的带隙比较低（0．87eV），故其可以作为潜在的导电材料．     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

Two Innovative Coalition Formation Models for Dynamic Task Allocation in Disaster Rescues

This paper addresses the problem of multi-objective coalition formation for task allocation. In disaster rescue, due to the dynamics of environments, heterogeneity and complexity of tasks as well as limited available agents, it is hard for the single-objective and single (task)-to-single (agent) task allocation approaches to handle task allocation in such circumstances. To this end, two multi-objective coalition formation for task allocation models are proposed for disaster rescues in this paper. First, through coalition formation, the proposed models enable agents to cooperatively perform complex tasks that cannot be completed by single agent. In addition, through adjusting the weights of multiple task allocation objectives, the proposed models can employ the linear programming to generate more adaptive task allocation plans, which can satisfy different task allocation requirements in disaster rescue. Finally, through employing the multi-stage task allocation mechanism of the dynamic programming, the proposed models can handle the dynamics of tasks and agents in disaster environments. Experimental results indicate that the proposed models have good performance on coalition formation for task allocation in disaster environments, which can generate suitable task allocation plans according to various objectives of task allocation.     

低碳约束下青岛市就业结构评价与优化研究

在国家提出发展低碳经济的背景下,为了分析低碳约束下青岛市就业结构优化水平,选取青岛市9个行业2004-2015年的数据,通过面板数据模型研究不同行业碳排放强度和就业结构之间的关系。结果表明,青岛市同行业自身的碳排放强度存在差异,与就业人口的关系也存在较大差异。最后根据评价结果,提出调整能源结构、寻找绿色经济增长点以及促进绿色就业从而实现低碳约束下就业结构优化的建议。     

浅析食货派的史学影响

食货派的学术研究,无论是在民国时期,还是在新中国建立以后,无论是在大陆,还是在台湾及海外都产生了重大而深远的影响.食货派在推动我国社会经济史学科发展方面作出了不可磨灭的贡献.食货派的“魏晋封建说”成为中国社会史分期中极具影响力的一种学说.他们的中国社会经济史研究中的一些学术观点化为了现代学术的一部分,被学者频频引用.《食货》半月刊与南京《中央日报·食货周刊》是台湾《食货》月刊复刊的渊源.从食货派绵远的学脉谱系中,食货派学人何兹全和沈任远的学术成就也成为了一道淡雅的风景.食货派在中国近代史学史上的地位不容忽视.     

基础教育数学物理化学教材用字用词调查（二）

为了更好地了解语言学习、语言能力培养与学科知识获取之间的关系，语言学习、语言能力培养与学科知识获取之间的关系，论文统计了基础教育阶段的数学、物理、化学三科教材中汉字、词语的使用情况，分析了它们的字词的种数、使用频率数、与语文科教材的用字用词的共见与独见情况。发现它们的字种数、词种数及总词次较少，复现率较低主要由以下四类构成：1．学科术语；2．一般性的语文字词；3．指称日常生活中一些特定的物、人、事的字词；4．教学类字词。     

含两参数的三阶非线性常微分方程Robin边值问题的奇摄动（Ⅰ）

研究含两参数的三阶非线性常微分方程Robin边值问题的奇摄动，在适当的条件下讨论了当（ε/μ^2)→0（μ→0）时解的存在性并获得其一致有效的渐近估计。     

从《现代汉语词汇》到《现代汉语词汇学》——回顾葛本仪先生的词汇学思想与成就

葛本仪教授是国内著名词汇学家,致力于汉语词汇理论研究。她在不同时间撰就的四部概论性教材:《现代汉语词汇》(1961)、《汉语词汇研究》(1985)、《汉语词汇论》(1997)、《现代汉语词汇学》(2001),清晰地反映了现代汉语词汇理论体系的建立与完善过程,在她的著作中表现出了由形式到意义、由结构到关系、由微观问题到宏观把握的研究趋势,体现出了注重词汇结构层次、结构与意义并重的词汇学思想。对诸如复合词素术语的确立、动态词义的产生机理、特征及作用,都做出了富于创见的论述。她的词汇理论上的许多创见与研究风格,都在诸多弟子的学术探索中得到了很好的继承。     

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

Chromosomal aberrations are a hallmark of acute lymphoblastic leukaemia (ALL) but alone fail to induce leukaemia. To identify cooperating oncogenic lesions, we performed a genome-wide analysis of leukaemic cells from 242 paediatric ALL patients using high-resolution, single-nucleotide polymorphism arrays and genomic DNA sequencing. Our analyses revealed deletion, amplification, point mutation and structural rearrangement in genes encoding principal regulators of B lymphocyte development and differentiation in 40% of B-progenitor ALL cases. The PAX5 gene was the most frequent target of somatic mutation, being altered in 31.7% of cases. The identified PAX5 mutations resulted in reduced levels of PAX5 protein or the generation of hypomorphic alleles. Deletions were also detected in TCF3 (also known as E2A), EBF1, LEF1, IKZF1 (IKAROS) and IKZF3 (AIOLOS). These findings suggest that direct disruption of pathways controlling B-cell development and differentiation contributes to B-progenitor ALL pathogenesis. Moreover, these data demonstrate the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer.