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991.
广义奇圈的同构因子分解 总被引:2,自引:0,他引:2
广义圈是一个简单图G =(V ,E) ,其中点集V =V0 ∪…∪Vn - 1 ,|V0 | =… |Vn - 1 | ,边集Euν|u∈Vi,ν∈Vi 1 ,i=0 ,…n -1,i 1=mod(n) .证明了广义奇圈可以分解为t个同构因子的充要条件是t可以整除该广义奇圈的边数 相似文献
992.
以不同粒径球形Ni(OH)2为活性材料,以泡沫镍为导电基体,制备氢氧化镍电极,进行活性检测.结果表明,以按一定粒径比例混合的Ni(OH)2为活性物质所制备的电极,其电化学活性最高. 相似文献
993.
ZHENG Jinjun QI Yongqing HUA Lizhong HE Xiubin ZHANG Xinbao 《武汉大学学报:自然科学英文版》2006,11(4):984-988
0IntroductionNeijiang City locates in the south of The SichuanHilly Basin.The Sichuan Hilly Basin is underlainby horizontally bedded Mesozoic mudstones,siltstonesand sandstones.Purple soils developed on these rapidlyweathering rocks are widely distributed across the basin.According to second state soil erosion surveys based onremote sensing,the soil erosion rates in local area aretypicallyinthe range of3000-5000t·km-2·a-1[1,2].Inthe Sichuan Hilly Basin,one sloping field may is com-pose… 相似文献
994.
PTC124 targets genetic disorders caused by nonsense mutations 总被引:1,自引:0,他引:1
Welch EM Barton ER Zhuo J Tomizawa Y Friesen WJ Trifillis P Paushkin S Patel M Trotta CR Hwang S Wilde RG Karp G Takasugi J Chen G Jones S Ren H Moon YC Corson D Turpoff AA Campbell JA Conn MM Khan A Almstead NG Hedrick J Mollin A Risher N Weetall M Yeh S Branstrom AA Colacino JM Babiak J Ju WD Hirawat S Northcutt VJ Miller LL Spatrick P He F Kawana M Feng H Jacobson A Peltz SW Sweeney HL 《Nature》2007,447(7140):87-91
Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from <1% to as little as 5% of normal levels may greatly reduce the severity or eliminate the principal manifestations of disease. To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons. PTC124 activity, optimized using nonsense-containing reporters, promoted dystrophin production in primary muscle cells from humans and mdx mice expressing dystrophin nonsense alleles, and rescued striated muscle function in mdx mice within 2-8 weeks of drug exposure. PTC124 was well tolerated in animals at plasma exposures substantially in excess of those required for nonsense suppression. The selectivity of PTC124 for premature termination codons, its well characterized activity profile, oral bioavailability and pharmacological properties indicate that this drug may have broad clinical potential for the treatment of a large group of genetic disorders with limited or no therapeutic options. 相似文献
995.
The c-myc coding DNA sequences of cyprinids (Teleostei: Cypriniformes): Implications for phylogeny 总被引:1,自引:0,他引:1
KONG XiangHui WANG XuZhen GAN XiaoNi HE ShunPing 《科学通报(英文版)》2007,52(11):1491-1500
The family Cyprinidae is one of the largest fish families in the world, which is widely distributed in East Asian, with obvious difference in characteristic size among species. The phylogeneUc analysis of cyprinid taxa based on the functionally important genes can help to understand the speciation and functional divergence of the Cyprinidae. The c-myc gene is an important gene regulating individual growth. In the present study, the sequence variations of the cyprinid c-myc gene and their phylogenetic significance were analyzed. The 41 complete sequences of the c-myc gene were obtained from cyprinids and outgroups through PCR amplification and clone. The coding DNA sequences of the c-myc gene were used to infer molecular phylogenetic relationships within the Cyprinidae. Myxocyprinus asiaticus (Catostomidae), Misgurnus anguillicaudatus (CobiUdae) and Hemimyzon sinensis (Homalopteridae) were assigned to the outgroup taxa. Phylogenetic analyses using maximum parsimony (MP), maximum likelihood (ML), and Bayesian retrieved similar topology. Within the Cyprinidae, Leuciscini and Barbini formed the monophyletic lineage respectively with high nodal supports. Leuciscini comprises Xenocyprinae, CuItrinae, East Asian species of Leuciscinae and Danioninae, Gobioninae and Acheilognathinae, and Barbini contains Schizothoracinae, Barbinae, Cyprininae and Labeoninae. Danio rerio, D. myersi and Rasbora trilineata were supposed to separate from Leuciscinae and Barbini and to form another lineage. The positions of some Danioninae species were still unresolved. Analyses of both amino acid variation with parsimony information and two high variation regions indicated that there is no correlation between variations of single amino acid or high variation regions and characteristic size of cyprinids. In addition, the species with smaller size were usually found to be basal within clades in the tree, which might be the results of the adaptation to the primitive ecology and survival pressure. 相似文献
996.
下关作为大理白族自治州首府,是政治、经济、文化的交流中心。由于长期的多民族杂居,在语言上形成了具有地方特色的下关方言。下关方言中的叠音后缀形容词极为丰富,通过详尽的搜集整理,主要从两个角度进行类型分析,一是结构上分为词根与词缀;二是形式上分为ABB式与ABCD式。并概括出下关方言叠音后缀形容词的语法特征、语法功能以及语用功能。从而得出其作用在于加深所修饰事物状态的程度,充分地表达出说话人的情感;具有绘形、着色、描味的作用,富于较强的节奏感。 相似文献
997.
从实习场地、实习教学过程和课后作业等方面对专业知识的渗透教学做了介绍,并通过实例要求学生深刻理解专业知识,熟练掌握车工操作技能,将车工专业知识渗透到实习教学中. 相似文献
998.
研究了凝胶注模成型的各种工艺因素对Al2O3-SiC复相陶瓷悬浮体的黏度和固化时间的影响。结果表明:控制溶液的pH值为7~8时,采用2%(wB)的ADS1分散剂,可制备出固相体积分数为60%,黏度为640mPa·s的悬浮体;随成型温度的升高,悬浮体的固化时间逐渐缩短;随着引发剂尤其是催化剂加入量的增加,悬浮体的固化时间明显缩短。 相似文献
999.
TIAN He ZHANG YunDong WANG Nan YUAN Ping 《科学通报(英文版)》2007,52(22):3047-3050
In order to control group velocity,an annular chain of microring coupled-resonator optical waveguides was analyzed,and its transmission spectra were obtained using the transfer matrix method. The result showed that the curvature of the chain caused the dispersion curves to shift and the resonance fre-quency got fixed. It is therefore concluded that the group velocity of light in the annular chain of mi-croring coupled-resonator optical waveguides can be controlled by adjusting the curvature of the chain. We believe that such an annular chain can be used as an optical buffer or signal retarder for optical communication. 相似文献
1000.
为改善高速车辆的方向稳定性,研究了左右轴距不等及车身纵轴线与前后车轴中点连线不重合的2种制造/安装偏差,及其导致车辆高速行驶时出现跑偏现象的机理及相关影响.建立了这2种制造/安装偏差导致高速车辆发生跑偏运动的动力学模型,推导出其状态方程,并通过数值仿真定量解析了这2种制造/安装偏差对车辆高速方向稳定性的影响.研究结果表... 相似文献