乌骨藤化学成分和生物活性研究进展

综述了近年来乌骨藤化学成分和生物活性研究方面的进展,主要包括化学成分、生物活性、临床应用概述,并对它的研究和应用前景作了展望。     

Design and passive analysis of a novel softness display device

Simulating the softness property of object is quite a challenge in virtual reality system. A novel softness display system was developed based on the principle of deformable length of elastic element control （DLEEC）. In the system, the equivalent stiffness of the device is adjustable, and is inversely proportional to the third power of the deformable length of elastic beam. PD position control is employed to guarantee the accurate softness display. The softness of the virtual objects in large scale can be felt with the softness display device. Compared with other haptic devices, the device is passive and exert the react force only when the operator ＂actively touch＂ the virtual objects. The stability of the softness display system was analyzed. It was theoretical proved that the system satisfied the criteria of wide impedance range ＂Z-width＂, and the performance was superior to an active system. The experimental results were presented.     

The radial self-positioning algorithm of intelligent ultrasonic probe array in oil/gas pipeline

The working principle of the pipeline intelligent pig and the structure of ultrasonic probe array used to detect defects in oil/gas pipeline are introduced.The effects of the array'S radial position in pipe on defect resolution are analyzed.The causes leading to radial positioning error are investigated.An algorithm for the radial self-positioning is presented.The experimental results show that the radial self-positioning algorithm can eliminate the array'S space position error effectively and improve the defect resolution.     

啤酒花中异葎草酮体外抗肿瘤作用及机制研究

研究啤酒花(Humulus Lupulus L.)中成分异葎草酮(tetrahydro-iso-α-acid)对人胃腺癌细胞SGC-7901和人肝癌细胞HepG-2的体外抑制作用,并初步揭示其抗肿瘤的作用机制.以MTT法进行细胞毒测定;采用流式细胞仪观察异葎草酮对肿瘤细胞凋亡的影响;细胞线粒体跨膜电位(MMP)测定用罗丹明123(Rhodamine l23,Rh123)标记,以流式细胞仪检测.异葎草酮对SGC-7901和HepG-2的IC50分别为13.4μg/mL和11.58μg/mL.异葎草酮作用于SGC-7901和HepG-2细胞48 h后,肿瘤细胞均有明显凋亡峰出现.异葎草酮可以导致SGC-7901和HepG-2细胞内线粒体膜电位明显下降,并呈剂量依赖关系.结果表明,异葎草酮对肿瘤细胞SGC-7901及HepG-2均有较强抑制作用,这一作用是通过诱导肿瘤细胞凋亡实现的.异葎草酮是通过线粒体路径启动细胞凋亡的,而且诱导线粒体功能异常可能是其引起细胞凋亡发生的主要作用机理.     

离子强度对牛磺酸离子交换平衡的影响

采用静态吸附法研究离子强度对牛磺酸/OH-体系在阴离子树脂D290上离子交换平衡的影响,测定了不同离子强度下牛磺酸在碱式阴离子交换树脂上的交换平衡等温线.研究结果表明:(1)随着溶液离子强度的升高,阴离子树脂对牛磺酸的平衡交换吸附容量逐渐降低,牛磺酸在树脂上的分配系数λTau逐渐下降;(2)随着溶液离子强度增大,达到平衡时液相的pH值升高,溶液中牛磺酸阴离子Tau±含量迅速增加,而牛磺酸两性离子Tau±含量迅速降低;(3)在一定的牛磺酸浓度范围内,溶液离子强度增大,有利于提高离子交换树脂对牛磺酸的选择性.     

中条山混沟原始森林地区野生药用植物资源研究

在混沟植物区系分析研究的基础上,对混沟地区的野生药用植物资源进行了初步统计,药用植物共有94科234属304种,按照其功效分为13类,并对该地区的野生药用植物资源的保护和利用进行了讨论.     

中国大额实时支付系统参与者的流动性管理

文章度量了中国主要商业银行在RTGS系统中流动性管理水平,通过与发达国家商业银行的流动性管理状况比较,发现我国商业银行在流动性管理方面存在很大差距,并深入分析了造成这种状况的主要原因.文章进一步讨论了提高流动性管理水平的方法,建立了单个商业银行流动性管理的理论模型,最后给出了流动性管理的最优水平.     

模糊检索系统研究

模糊性是人类思维和客观事物普遍具有的属性之一。为了克服现行计算机信息系统的局限性 ,模糊检索应运而生。运用模糊技术开发的计算机信息系统既允许用户用自然语言进行信息查询 ,又能给出输出信号项与用户查询的关联度 ,协助用户完成信息处理任务 ,因而具有一定的人脑进行模糊信息处理的能力。简要讨论了模糊检索系统的结构 ,模糊知识库及其管理 ,模糊数据库的组织等。     

A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase

Grain weight is one of the most important components of grain yield and is controlled by quantitative trait loci (QTLs) derived from natural variations in crops. However, the molecular roles of QTLs in the regulation of grain weight have not been fully elucidated. Here, we report the cloning and characterization of GW2, a new QTL that controls rice grain width and weight. Our data show that GW2 encodes a previously unknown RING-type protein with E3 ubiquitin ligase activity, which is known to function in the degradation by the ubiquitin-proteasome pathway. Loss of GW2 function increased cell numbers, resulting in a larger (wider) spikelet hull, and it accelerated the grain milk filling rate, resulting in enhanced grain width, weight and yield. Our results suggest that GW2 negatively regulates cell division by targeting its substrate(s) to proteasomes for regulated proteolysis. The functional characterization of GW2 provides insight into the mechanism of seed development and is a potential tool for improving grain yield in crops.     

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.