Semiparametric Preference Learning

Unlike traditional supervised learning problems,preference learning learns from data available in the form of pairwise preference relations between instances.Existing preference learning methods are either parametric or nonparametric in nature.We propose in this paper a semiparametric preference learning model,abbreviated as SPPL,with the aim of combining the strengths of the parametric and nonparametric approaches.SPPL uses multiple Gaussian processes which are linearly coupled to determine the preference relations between instances.SPPL is more powerful than previous models while keeping the computational complexity low （linear in the number of distinct instances）.We devise an efficient algorithm for model learning.Empirical studies have been conducted on two real-world data sets showing that SPPL outperforms related preference learning methods.     

Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases

Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn), kynurenic acid (KA), 3-hydroxykynurenine (3-HK), xanthurenic acid (XA), and 3-hydroxyanthranilic acid (3-HAA). Increased catabolite concentrations in serum are associated with several cardiovascular diseases (CVD), including heart disease, atherosclerosis, and endothelial dysfunction, as well as their risk factors, including hypertension, diabetes, obesity, and aging. The first catabolic step in KP is primarily controlled by indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). Following this first step, the KP has two major branches, one branch is mediated by kynurenine 3-monooxygenase (KMO) and kynureninase (KYNU) and is responsible for the formation of 3-HK, 3-HAA, and quinolinic acid (QA); and another branch is controlled by kynurenine amino-transferase (KAT), which generates KA. Uncontrolled Trp catabolism has been demonstrated in distinct CVD, thus, understanding the underlying mechanisms by which regulates KP enzyme expression and activity is paramount. This review highlights the recent advances on the effect of KP enzyme expression and activity in different tissues on the pathological mechanisms of specific CVD, KP is an inflammatory sensor and modulator in the cardiovascular system, and KP catabolites act as the potential biomarkers for CVD initiation and progression. Moreover, the biochemical features of critical KP enzymes and principles of enzyme inhibitor development are briefly summarized, as well as the therapeutic potential of KP enzyme inhibitors against CVD is briefly discussed.     

Collaborative Project Management: A Systemic Approach to Heavy Equipment Manufacturing Project Management

Quite often over the last decade, heavy equipment manufacturers are trying to improve their project management performance with the use of effective project management methods. However, the challenges encountered aren’t isolated problems and a systemic approach is required. This paper exemplifies how a systemic approach can be applied to heavy equipment manufacturing project (HEMP) management, through of a multifaceted vision. The findings present in the paper are based on a two-year case study in a metallurgic equipment manufacturing enterprise in China. Based on the analysis of HEMP management problems and the contributions on systemic approach application in project management, the paper enriches existing theory by: (1) interpreting the HEMP management system with the top-down disassembly method; (2) developing the collaborative project management approach with a systems view highlighting the project characteristics management and inter-departmental collaboration; (3) making suggestions for systemic approach application in project management. For practitioners and researchers, the findings are particularly meaningful for manufacturing project management and systemic approach application.     

一种新的军事概念建模方法

军事概念模型建模是作战复杂系统建模与仿真的重要环节。该文提出了一种包含面向过程任务空间概念建模与面向对象仿真空间建模两个阶段的军事概念模型建模方法。该方法方便军事人员与仿真人员从不同视角对作战系统进行抽象描述。最后,该文通过一个空基反导作战案例,对这一方法进行了验证。     

既有建筑结构加固技术方法探讨

随着我国社会发展的需求和经济建设的发展,建筑加层加固技术在现阶段广泛应用于社会生产实践。作为一门理论与实践相结合的综合性技术,目前没有完全统一的加固理论,因此,文章主要介绍了几种常用的加固技术方法,为建筑物的加固提供一定的技术支持。     

本科院校外语实验技术队伍调查分析

随机选取国内60个本科院校,调研了外语实验技术队伍的数量和结构,队伍的管理,工作与收入,学习与科研等。同时也初步调查了实验技术设备的现状,以及实验室常规工作中存在的问题。根据调查数据,指出了队伍中比较突出的一些现状问题。     

Self-alignment of full skewed RSINS：observability analysis and full-observable Kalman filter

Traditional orthogonal strapdown inertial navigation sys-tem （SINS） cannot achieve satisfactory self-alignment accuracy in the stationary base： taking more than 5 minutes and al the iner-tial sensors biases cannot get ful observability except the up-axis accelerometer. However, the ful skewed redundant SINS （RSINS） can not only enhance the reliability of the system, but also improve the accuracy of the system, such as the initial alignment. Firstly, the observability of the system state includes attitude errors and al the inertial sensors biases are analyzed with the global perspective method： any three gyroscopes and three accelerometers can be assembled into an independent subordinate SINS （sub-SINS）;the system state can be uniquely confirmed by the coupling connec-tions of al the sub-SINSs;the attitude errors and random constant biases of al the inertial sensors are observable. However, the ran-dom noises of the inertial sensors are not taken into account in the above analyzing process. Secondly, the ful-observable Kalman filter which can be applied to the actual RSINS containing random noises is established; the system state includes the position, ve-locity, attitude errors of al the sub-SINSs and the random constant biases of the redundant inertial sensors. At last, the initial self-alignment process of a typical four-redundancy ful skewed RSINS is simulated： the horizontal attitudes （pitch, rol ） errors and yaw error can be exactly evaluated within 80 s and 100 s respectively, while the random constant biases of gyroscopes and accelero-meters can be precisely evaluated within 120 s. For the ful skewed RSINS, the self-alignment accuracy is greatly improved, mean-while the self-alignment time is widely shortened.     

早产儿视网膜病变高危致病因素的多因素分析

目的:回顾性研究早产儿视网膜病变(ROP)发生的高危致病因素。方法:对接受筛查的胎龄≤34周或出生体质量≤2 000 g的早产儿进行眼底检查,并对ROP高危致病因素进行多因素Logistic多元回归分析。结果:完成筛查的219例早产儿中,21例(42只眼)发生ROP,占9.6%,其中阈值病变6例(12只眼),占2.7%。单因素分析显示,ROP的发生与出生体质量、孕周、首次救治医院有无新生儿急危症监护室(NICU)、吸氧5 d、窒息以及贫血等6项高危因素有关;多因素Logistic多元回归分析表明,出生体质量、孕周、吸氧5 d、宫内窘迫等4因素与ROP发生有相关性。结论:ROP的发生与孕周短、出生体质量低和吸氧时间长等各致病因素间的综合作用有关。     

Exact inference for two exponential populations with competing risks data

In a reliability comparative test, the joint censoring model is usually adopted to evaluate the performances of units with the same facility. However, most researchers ignore the pos- sibility that there is more than one factor for the failure when a test unit fails. To solve this problem, we consider a joint Type-II hybrid censoring model for the analysis of exponential competing failure data. Based on the maximum likelihood theory, we compute the maximum likelihood estimators （MLEs） of parameters and then obtain the condition ensuring MLEs existence for every unknown parameter. Then we derive the conditional exact distributions and corresponding moment properties for parameters by the moment generating function （MGF）. A Monte-Carlo simulation is conducted to compare the performances of different ways. And finally, we conduct a numerical example to illustrate the proposed method.     

1000 mm2 cross-section wire a led four tension exhibition put to traction practice

文章介绍了宁东一山东±660 kV直流输电示范工程(晋4标段)1 000 mm2大截面导线一牵四张力展放施工中,使用4个转向滑车转向布置牵引场的实践过程及施工中的注意事项.