Cytoglobin: biochemical,functional and clinical perspective of the newest member of the globin family

Since the discovery of cytoglobin (Cygb) a decade ago, growing amounts of data have been gathered to characterise Cygb biochemistry, functioning and implication in human pathologies. Its molecular roles remain under investigation, but nitric oxide dioxygenase and lipid peroxidase activities have been demonstrated. Cygb expression increases in response to various stress conditions including hypoxia, oxidative stress and fibrotic stimulation. When exogenously overexpressed, Cygb revealed cytoprotection against these factors. Cygb was shown to be upregulated in fibrosis and neurodegenerative disorders and downregulated in multiple cancer types. CYGB was also found within the minimal region of a hereditary tylosis with oesophageal cancer syndrome, and its expression was reduced in tylotic samples. Recently, Cygb has been shown to inhibit cancer cell growth in vitro, thus confirming its suggested tumour suppressor role. This article aims to review the biochemical and functional aspects of Cygb, its involvement in various pathological conditions and potential clinical utility.     

基于EMD与多重分形去趋势法的轴承智能诊断方法

引入经验模态分解(EMD)方法去除故障信号的趋势项,提出EMD-MFDFA(multifractal detrended fluctuation analysis)的多重分形分析方法,并通过仿真分析EMD方法去趋势效果的有效性。然后将采用EMD-MFDFA方法提取的电机滚动轴承振动信号的多重分形特征向量作为训练集,利用混合遗传算法搜索全局最优的能力优化支持向量机(SVM)模型参数,建立电机滚动轴承的智能诊断模型。最后,通过对电机滚动轴承不同状态的振动信号进行分析。研究结果表明:EMD-MFDFA方法能很好地揭示滚动轴承的振动信号多重分形特性,对滚动轴承正常状态、单一故障与多故障耦合等状态具有很强的辨识能力;所建立的智能诊断模型可以有效地诊断滚动轴承不同的故障状态,能够作为滚动轴承故障在线监测的有效工具。     

7LiH分子X1Σ+态的平衡几何、谐振频率、离解能及其解析势能函数

利用分子反应静力学的原理,确定了7L iH分子X1Σ 态的合理离解极限;使用HF、QC ISD、QC ISD(T)、B3LYP和B3P86等方法,6-311G、6-311G(d,p)、6-311G(3df,3pd)、D95V(d,p)和D95V(3df,3dp)等基组,对7LiH分子X1Σ 态的平衡核间距、谐振频率和离解能进行了优化计算,且将计算结果(平衡核间距0.160 9 nm、谐振频率1 390.51 cm-1、离解能2.474 eV)与实验结果(平衡核间距0.159 6 nm、谐振频率1 405.7cm-1、离解能2.515 eV)进行了比较,得出了包含单、双取代并加入三重激发贡献的QC ISD(T)方法为最优方法、基组6-311G(3df,3pd)为最优基组的结论.在QC ISD(T)/6-311G(3df,3pd)理论水平,对7LiH分子的X1Σ 态进行了单点能扫描,并用最小二乘法拟合出了其解析势能函数;从拟合出的解析势能函数出发,计算出了X1Σ 态的光谱常数Be,αe和ωeeχ(其值分别为7.379 cm-1、0.197 6 cm-1和21.697 cm-1),以及二阶、三阶和四阶力常数f2、f3和f4(其值分别为106.37 aJ.nm-2、-3 650.4 aJ.nm-3和112 176.2 aJ.nm-4).     

基于句子相关度的文本自动分类

提出一种基于句子相关度的文本自动分类模型（TCSC）.该模型利用训练样本增量式地自动更新类别语料库,根据句子的位置权值和语料权值计算句子类别相关度,获得用于文本分类的句子相关度矩阵,通过该矩阵实现文档分类.该模型避免了分类阶段待分类文本特别是中文文本的分词,模糊了词的多义问题,且在文本分类的实验中能够达到86%以上的查全率和查准率;随着语料库的不断训练和调整,分类性能还可以进一步提高,具有简单实现的特点.     

蜂胶作为运动补剂的潜在应用价值

蜂胶是一种非常有效的天然抗氧化剂，国内外正在掀起研究蜂胶的热潮。本文简述了蜂胶的成分以及性质。尤其蜂胶由于具有黄酮类物质而产生的抗氧化性。在此基础上提出了蜂胶作为运动补剂的潜在应用价值。     

Occurrence of Neoproterozoic low-grade metagranite in the western Beihuaiyang zone,the Dabie orogen

Based on detailed field investigations and petrographic observations, we discovered Neoproterozoic-emplaced granite from the metavolcanics of the Dingyuan Formation in the western Beihuaiyang zone, the Dabie orogen. This study reports the results of zircon U-Pb dating and preliminary petrographic observations on two metagranite samples. The studied rocks experienced epidote-amphibolite facies metamorphism and strong structural deformation. Their U-Pb ages are 726 ± 6 and 758 ± 12 Ma, respectively, similar to those for the Luzhenguan complex in the eastern segment of the Beihuaiyang zone. In combination with previously determined 635 ± 5 Ma low-grade metagabbro, this study suggests the occurrence of at least two types of Neoproterozoic intrusive rocks in the Beihuaiyang zone, the northern margin of the South China Block (SCB): 726–758 Ma metagranite and 635 Ma metagabbro. These rocks occur within the metamorphosed Ordovician volcanic zone (originally named the Dingyuan Formation) and are in tectonic contact to each other, but they formed in different tectonic settings. The protolith ages for the Neoproterozoic low-grade metaigneous rocks are in good agreement not only with ages for two episodes of mid- and late-Neoproterozoic mafic and felsic magmatism in the Suizhou and Zaoyang area, Hubei Province, but also agree with protolith ages of ultrahigh-pressure metaigneous rocks in the Dabie-Sulu orogenic belt. In view of their tectonic relationships to country rocks, it appears that these Neoproterozoic low-grade rocks are exotic and they may have been detached and scraped from subducting SCB crust in the early Triassic during the initial continental subduction, and thrusted over Paleozoic metamorphosed rocks in the southern margin of the North China Block during continental collision.     

川西丹巴燕子沟金矿床流体包裹体特征及矿床成因

燕子沟金矿床位于四川省丹巴县,大地构造位置位于扬子准地台西缘,松潘-甘孜造山带东缘.泥盆系危关组炭质千枚岩、板岩是主要的赋矿围岩.成矿过程分为沉积成矿期、热液期和风化期,其中热液期是金的主要成矿期.流体成矿过程包括3个阶段:石英-金硫化物阶段、硫盐-金(银)石英阶段和铅锌硫化物-金-碳酸盐阶段.流体包裹体以VCO2、LCO2和LH2O三相与两相包裹体为主,主要是H2O-CO2三相水溶液包裹体,另有纯液相和含CO2单相包裹体存在.金的成矿作用主要发生在中温(285～295 ℃)、浅成(0.11～0.92 km)、低盐度(w(NaCl) =2.22％～9.21％)、低密度(0.75～0.85 g/cm3)的物理化学条件下,岩浆岩体与矿化关系密切,既为成矿提供热源,也提供了一定的物质来源,并与大气降水共同作用,从而形成了沉积-热液改造型浅成中温金矿床.     

LOGISTICS SCHEDULING： ANALYSIS OFTWO-STAGE PROBLEMS

This paper studies the coordination effects between stages for scheduling problems where decision-making is a two-stage process. Two stages are considered as one system. The system can be a supply chain that links two stages, one stage representing a manufacturer; and the other, a distributor It also can represent a single manufacturer, while each stage represents a different department responsible for a part of operations. A problem that jointly considers both stages in order to achieve ideal overall system performance is defined as a system problem. In practice, at times, it might not be feasible for the two stages to make coordinated decisions due to (i) the lack of channels that allow decision makers at the two stages to cooperate, and/or (ii) the optimal solution to the system problem is too difficult (or costly) to achieve.Two practical approaches are applied to solve a variant of two-stage logistic scheduling problems. The Forward Approach is defined as a solution procedure by which the first sta     

First principles studies on the electronics structures of (Li<Subscript>1−<Emphasis Type="Italic">x</Emphasis></Subscript>Me<Subscript><Emphasis Type="Italic">x</Emphasis></Subscript>)FePO<Subscript>4</Subscript> (Me=Na and Be)

Based on density functional theory (DFT) of the first-principle for cathode materials of lithium ion battery, the electronic structures of (Li_1?x Me _x )FePO₄ (Me=Na and Be, x=0–0.40) are calculated by plane wave pseudo-potential method using Cambridge serial total energy package (CASTEP) program. The calculated results show that Li-site doping can improve the electronic conductivity enormously. Doping with Na has a noticeable effect on improving its electrical conductivity. However, serious structural distortion will occur when its doping density is beyond 0.25. In view of this, the best density of doping Na is less than 0.25. Doping with Be has an inconspicuous effect on increasing its electrical conductivity and has good cyclical stability, but it cannot achieve as good results as when it is doped with Na. Therefore we cannot find a middle ground between the two proposals. Considering cost and environmental protection, it is ideal to choose Na. So this method gives a reasonable prediction to the improvement of electronic conductivity through Li-site doping in LiFePO₄ material.     

Correlations for the ignition delay times of hydrogen/air mixtures

Correlations for the ignition delay times of hydrogen/air mixtures were developed using the method of High Dimensional Model Representation (HDMR).The hydrogen/air ignition delay times for initial conditions over a wide range of temperatures from 800 to 1600 K,pressures from 0.1 to 100 atm,and equivalence ratios from 0.2 to 10 were first calculated utilizing the full chemical mechanism.Correlations were then developed based on these ignition delay times.Two forms of correlations were constructed:the first one is an overall general model covering the whole range of the initial conditions;while the second one is a piecewise correlation model valid for initial conditions within different sub-domains.The performance of these correlations was studied through comparison with results from the full chemical mechanism as well as experimental data.It was shown that these correlations work well over the whole range of initial conditions and that the accuracy can be significantly improved by using different piecewise correlations for different sub-domains.Therefore,piecewise correlations can be used as an effective replacement for the full mechanism when the prediction of chemical time scale is needed in certain combustion modeling.