全文获取类型
收费全文 | 55篇 |
免费 | 0篇 |
专业分类
系统科学 | 3篇 |
现状及发展 | 15篇 |
研究方法 | 6篇 |
综合类 | 31篇 |
出版年
2012年 | 2篇 |
2011年 | 2篇 |
2007年 | 2篇 |
2006年 | 3篇 |
2005年 | 3篇 |
2003年 | 2篇 |
2000年 | 2篇 |
1999年 | 2篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 2篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1971年 | 3篇 |
1970年 | 4篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1965年 | 3篇 |
排序方式: 共有55条查询结果,搜索用时 203 毫秒
41.
Products of the major histocompatibility complex and their relationship to the immune response. 总被引:2,自引:0,他引:2
The genes of the major histocompatibility complex were first known for the part they played in transplant rejection. Recently, however, it has become clear that the products of that region have an important part to play in the control of the immune response, through their effects both on cooperative and on aggressive interactions between cells. It is now possible to guess at the mechanisms which may underly the association of some major histocompatibility antigens with disease. 相似文献
42.
43.
M. Tardy B. Rolland J. Bardakdjian P. Gonnard 《Cellular and molecular life sciences : CMLS》1978,34(7):823-824
Summary L-Carnosine, L-homocarnosine and L-anserine are inhibitors of GABA metabolism. They show differential action on GABA-transaminase from synaptosomes compared to the extrasynaptosomal enzyme. 相似文献
44.
This paper provides an exploration of how different understandings of man–machine systems have accompanied developments in Operational Research. In particular, the paper will challenge the notion that we are in a position of mastery with respect to technology. Both Hard OR and Soft OR are criticized for a failure to examine adequately the relationship between people and technology. Toward the end of the paper a new way of understanding this relationship will be proposed in terms of technologies of the self or what Michel Foucault called ethics. 相似文献
45.
The two forms isolated exhibit some differences concerning their physicochemical and functional properties. They are identical with the previously purified molecular fomrs, GABAT I and GABAT II, separated by DEAE cellulose chromatography. 相似文献
46.
47.
Sandilands A Terron-Kwiatkowski A Hull PR O'Regan GM Clayton TH Watson RM Carrick T Evans AT Liao H Zhao Y Campbell LE Schmuth M Gruber R Janecke AR Elias PM van Steensel MA Nagtzaam I van Geel M Steijlen PM Munro CS Bradley DG Palmer CN Smith FJ McLean WH Irvine AD 《Nature genetics》2007,39(5):650-654
We recently reported two common filaggrin (FLG) null mutations that cause ichthyosis vulgaris and predispose to eczema and secondary allergic diseases. We show here that these common European mutations are ancestral variants carried on conserved haplotypes. To facilitate comprehensive analysis of other populations, we report a strategy for full sequencing of this large, highly repetitive gene, and we describe 15 variants, including seven that are prevalent. All the variants are either nonsense or frameshift mutations that, in representative cases, resulted in loss of filaggrin production in the epidermis. In an Irish case-control study, the five most common European mutations showed a strong association with moderate-to-severe childhood eczema (chi2 test: P = 2.12 x 10(-51); Fisher's exact test: heterozygote odds ratio (OR) = 7.44 (95% confidence interval (c.i.) = 4.9-11.3), and homozygote OR = 151 (95% c.i. = 20-1,136)). We found three additional rare null mutations in this case series, suggesting that the genetic architecture of filaggrin-related atopic dermatitis consists of both prevalent and rare risk alleles. 相似文献
48.
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris 总被引:21,自引:0,他引:21
Smith FJ Irvine AD Terron-Kwiatkowski A Sandilands A Campbell LE Zhao Y Liao H Evans AT Goudie DR Lewis-Jones S Arseculeratne G Munro CS Sergeant A O'Regan G Bale SJ Compton JG DiGiovanna JJ Presland RB Fleckman P McLean WH 《Nature genetics》2006,38(3):337-342
Ichthyosis vulgaris (OMIM 146700) is the most common inherited disorder of keratinization and one of the most frequent single-gene disorders in humans. The most widely cited incidence figure is 1 in 250 based on a survey of 6,051 healthy English schoolchildren. We have identified homozygous or compound heterozygous mutations R501X and 2282del4 in the gene encoding filaggrin (FLG) as the cause of moderate or severe ichthyosis vulgaris in 15 kindreds. In addition, these mutations are semidominant; heterozygotes show a very mild phenotype with incomplete penetrance. The mutations show a combined allele frequency of approximately 4% in populations of European ancestry, explaining the high incidence of ichthyosis vulgaris. Profilaggrin is the major protein of keratohyalin granules in the epidermis. During terminal differentiation, it is cleaved into multiple filaggrin peptides that aggregate keratin filaments. The resultant matrix is cross-linked to form a major component of the cornified cell envelope. We find that loss or reduction of this major structural protein leads to varying degrees of impaired keratinization. 相似文献
49.
W. Wiltschko U. Munro H. Ford R. Wiltschko 《Cellular and molecular life sciences : CMLS》1993,49(2):167-170
We conducted orientation experiments with Silvereyes,Zosterops lateralis, Australian passerine migrants, to see whether birds living in the Southern Hemisphere in a magnetic field with an upward inclination orient in the same way as birds in the Northern Hemisphere that experience a downward inclination of the magnetic field. Tested indoors in the local geomagnetic field, the birds preferred southerly directions corresponding to their migratory direction in spring. In a magnetic field with a reversed vertical component, they reversed their directional tendencies. This shows that the magnetic compass of Silvereyes also functions as an inclination compass based on the inclination of the field lines instead of the polarity. 相似文献
50.
A magnetic pulse leads to a temporary deflection in the orientation of migratory birds 总被引:3,自引:0,他引:3
W. Wiltschko U. Munro R. C. Beason H. Ford R. Wiltschko 《Cellular and molecular life sciences : CMLS》1994,50(7):697-700
Migratory Australian Silvereyes were treated with a strong magnetic pulse designed to alter the magnetization of the small magnetite particles that are found in birds' heads. Prior to the treatment, the birds preferred the northeasterly migratory direction. The pulse initially resulted in a 90° clockwise shift of orientation; however, within about a week, the birds seemed to return to their original headings. These findings, which seem to suggest an involvement of magnetite in migratory orientation, are in contrast with previous findings which indicated that it is a light-dependent process. They are discussed in view of the current concepts on magnetoreception and on the role of magnetic information in avian orientation. 相似文献