SET domain protein lysine methyltransferases: Structure, specificity and catalysis

Site- and state-specific lysine methylation of histones is catalyzed by a family of proteins that contain the evolutionarily conserved SET domain and plays a fundamental role in epigenetic regulation of gene activation and silencing in all eukaryotes. The recently determined three-dimensional structures of the SET domains from chromosomal proteins reveal that the core SET domain structure contains a two-domain architecture, consisting of a conserved anti-parallel β-barrel and a structurally variable insert that surround a unusual knot-like structure that comprises the enzyme active site. These structures of the SET domains, either in the free state or when bound to cofactor S-adenosyl-L-homocysteine and/or histone peptide, mimicking an enzyme/cofactor/substrate complex, further yield the structural insights into the molecular basis of the substrate specificity, methylation multiplicity and the catalytic mechanism of histone lysine methylation. Received 10 June 2006; accepted 22 August 2006     

县域土地利用变化分析

以温州市永嘉县1990－1996年土地利用为研究内容,计算了有关土地利用的多种静态和动态指标,提出了新的土地利用动态量度的指标－结构转换度,并研究了各类土地利用及其变动人口密度、经济发展之间的关系。     

开关电容网络灵敏度分析的传递函数法

给出了一种开关电容网络(SCN)灵敏度分析的新方法。只要能写出SCN的z域改进节点电压方程,并且该方程系数矩阵在将z为e     

基于神经网络数据融合的目标跟踪简化算法

分析了基于神经网络数据融合的目标跟踪算法 ,指出了传统的融合算法计算量大 ,神经网络目标向量不易选取等缺点 ,并提出了一种简化的算法。应用理论分析和蒙特卡洛仿真方法 ,对标准卡尔曼滤波算法和简化的滤波算法进行了比较 ,并给出了均方根误差的统计值。该简化算法原理简单 ,数据处理量小 ,速度快 ,误差小 ,特别适用于多传感器的处理 ,将融合结果反馈给单传感器 ,可提高各单传感器的跟踪精度     

界面反应及界面张力对Sn-Zn-Bi焊料润湿性的影响

通过合金化的方式得到了Sn-Zn-Bi三元及Sn-Zn-Bi-Nd四元无铅焊料,采用润湿平衡法测量了其润湿力和润湿时间,并对润湿后的焊料/Cu界面组织进行了分析.结果表明:Bi元素不参与焊料/Cu界面的扩散反应,但能够通过吸附作用降低界面张力,从而提高焊料在Cu基底上的润湿力;Zn元素优先向焊料/Cu界面进行扩散形成Cu5Zn8金属间化合物,且扩散层随焊料中Zn含量的提高而增长,此时固-液界面张力方向发生改变,润湿力提高,但润湿时间延长;Nd元素的作用类似于Bi,既能提高焊料的润湿力,也能够缩短润湿时间,是一种改善Sn-Zn基焊料润湿性的有效元素.     

一种考虑杆件初始弯曲的非线性杆单元

在假定杆件初始弯曲为半波正弦曲线的基础上,提出考虑初始弯曲的非线性杆单元,推导了轴力与轴向变形的关系和轴向切线刚度的表达式,得到了初始弯曲对轴向刚度的影响系数.分析表明,初始弯曲影响与刚度比、初始弯曲幅值、轴力大小以及杆单元长度有关.结合某索拱结构工程实例,研究不同初始预应力取值下,杆件初始弯曲对结构非线性稳定性能的影响程度和影响规律,结果表明:杆件初始弯曲对结构屈曲前的整体刚度影响很小,但对结构的极限荷载与屈曲后性能影响较大;初始预应力取值的增加对结构的位移控制非常有效,但是对结构的刚度影响却很小;在不同初始预应力取值下,极限荷载随杆件初始弯曲变化的规律相似,并且都接近于线性.非线性杆单元能够广泛应用于桁架结构和网格结构的设计与分析,在考虑杆件初始弯曲后,将使结构的设计与分析更加合理、更加科学.     

叶尖间隙对小流量超音压气机级性能的影响

为研究叶尖间隙对级环境下压气机气动性能的影响,以带导叶的超音压气机级为研究对象,采用商用软件NUMECA对该压气机在转子叶尖间隙为0、0.3、0.6、0.9 mm时进行三维数值计算,分析了该压气机级气动性能及流动特点.结果表明:随着叶尖间隙的增大,转子叶尖处激波向上游移动;静子进口气流攻角增大,最终导致压气机稳定工作裕...     

RBC: A Memory Architecture for Improved Performance and Energy Efficiency

DRAM-based memory suffers from increasing row buffer conflicts, which causes significant performance degradation and power consumption. As memory capacity increases, the overheads of the row buffer conflict are increasingly worse as increasing bitline length, which results in high row activation and precharge latencies. In this work, we propose a practical approach called Row Buffer Cache(RBC) to mitigate row buffer conflict overheads efficiently. At the core of our proposed RBC architecture, the rows with good spatial locality are cached and protected,which are exempted from being interrupted by the accesses for rows with poor locality. Such an RBC architecture significantly reduces the overheads of performance and energy caused by row activation and precharge, and thus improves overall system performance and energy efficiency. We evaluate RBC architecture using SPEC CPU2006 on a DDR4 memory compared to a commodity baseline memory system. Results show that RBC improves the overall performance by up to 2:24(16:1% on average) and reduces the memory energy by up to 68:2%(23:6% on average) for single-core simulations. For multi-core simulations, RBC increases the overall performance by up to1:55(17% on average) and reduces memory energy consumption by up to 35:4%(21:3% on average).     

Efficient Static Compaction of Test Patterns Using Partial Maximum Satisfiability

Static compaction methods aim at finding unnecessary test patterns to reduce the size of the test set as a post-process of test generation.Techniques based on partial maximum satisfiability are often used to track many hard problems in various domains,including artificial intelligence,computational biology,data mining,and machine learning.We observe that part of the test patterns generated by the commercial Automatic Test Pattern Generation(ATPG) tool is redundant,and the relationship between test patterns and faults,as a significant information,can effectively induce the test patterns reduction process.Considering a test pattern can detect one or more faults,we map the problem of static test compaction to a partial maximum satisfiability problem.Experiments on ISCAS89,ISCAS85,and ITC99 benchmarks show that this approach can reduce the initial test set size generated by TetraMAX18 while maintaining fault coverage.