Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

几何相似体应力-应变分布相同时的载荷关系

为了保证几何相似模型与原件具有完全相同的应力-应变分布,必须对几何相似模型施加与实际构件成对应比例的各种载荷,因此需要寻求几何相似模型在应力-应变分布完全相同时各种外加载荷的比例关系。从相似理论入手,以2端固支的矩形梁下表面边线中点的应力解析表达式为基础进行推导,得出相应的理论载荷关系,并用算例在弹塑性状态下验证了所得关系的正确性。得到的结论是:对于2个几何相似构件,若几何相似系数为kl,则当外加集中载荷的载荷系数为kl、均布线载荷的载荷系数为kl、均布面载荷的载荷系数为1时,2构件的应力-应变分布完全相同。     

时域中系统鲁棒稳定性的定量计算

本文定量地考虑了当系统参数受到干扰时的稳定性问题。目的为对以状态空间法表示的线性系统鲁棒稳定性的定量计算提出一个统一的结论。文中首先对摄动的分类及对用李亚普诺夫理论求解受扰系统鲁棒稳定性的历史结果进行了述评,进而对其摄动的允许界限的计算提出了新方法。实例表明所示结果较少保守性。     

鄂尔多斯盆地腹部下古生界天然气赋存系统研究

运用深盆气圈闭的基本原理，综合分析了鄂尔多斯盆地下古生界天然气赋存的基本地质因素，论证并提出了盆地腹部下古生界深盆气圈闭的新认识，并依据盆地地质构造特征将其进一步划分为：西部前渊拗陷型和中东部复式向斜型两大深盆气赋存系统．     

耐火砖模具设计中空间平面尺寸的合理标注

分析空间四边平面加工过程中产生不共面的原因，提出了合理标注空间平面尺寸的方法并阐述了其理论根据。     

象质评价中光学孔径与波象差的最佳匹配

导出了光学孔径与波象差共同决定成象质量的一些关系式，并从理论和实践两方面找出上述两参数的最佳匹配范围。文中得出的结果与以往传统的象质评价判据有明显的区别。     

炭黑／结晶性含氟树脂合金在自控温加热电缆中应用

选择了结晶性含氟树脂添加改性剂为树脂基体，与炭黑制居复合导电体系。通过这个对体系不同条件下ＰＴＣ特性的研究，对其配方与加工工艺进行优化。并利用扫描电镜，Ｘ射线衍射，ＤＳＣ等分析测试手段，对体系的各种开矿结构进行了研究，阐明了该导电复合体系的形态结构与性能的关系。