Resistant orthogonal procrustes analysis

In this paper two alternative loss criteria for the least squares Procrustes problem are studied. These alternative criteria are based on the Huber function and on the more radical biweight function, which are designed to be resistant to outliers. Using iterative majorization it is shown how a convergent reweighted least squares algorithm can be developed. In asimulation study it turns out that the proposed methods perform well over a specific range of contamination. When a uniform dilation factor is included, mixed results are obtained. The methods also yield a set of weights that can be used for diagnostic purposes.     

Exocytotic fusion is activated by Rab3a peptides.

Studies of intracellular traffic in yeast and mammalian systems have implicated members of the Rab family of small GTP-binding proteins as regulators of membrane fusion. We have used the patch clamp technique to measure exocytotic fusion events directly and investigate the role of GTP-binding proteins in regulating exocytosis in mast cells. Intracellular perfusion of mast cells with GTP-gamma S is sufficient to trigger complete exocytotic degranulation in the absence of other intracellular messengers. Here we show that GTP is a potent inhibitor of GTP-gamma S-induced degranulation, indicating that sustained activation of a GTP-binding protein is sufficient for membrane fusion. We have found that synthetic oligopeptides, corresponding to part of the effector domain of Rab3a, stimulate complete exocytotic degranulation, similar to that induced by GTP-gamma S. The response is selective for Rab3a sequence and is strictly dependent on Mg2+ and ATP. This suggests that sustained activation of a Rab3 protein causes exocytotic fusion. The peptide response can be accelerated by GDP-beta S, suggesting that Rab3a peptides compete with endogenous Rab3 proteins for a binding site on a target effector protein, which causes fusion on activation.     

Trying times for human insulin.

The introduction of human insulin to treat diabetics seemed straightforward. What can account for the problems that have followed?     

精密镗削头振动模态的实验研究

通过对国产与进Ｄ的同类型精密镗削头振动模态实验研究，找出了这两种精密镗削头的固有振动频率，给出了它们的各阶动画振型图．从这一侧面解释了国产精密镗削头回转精度偏低的原因。     

企业文化定位的影响因素分析

通过讨论企业性质、企业能动要素价值的变迁以及企业的素质和外部环境状况对企业文化定位的影响,认为不同的企业都有其独特的个性,因而企业文化必须根据企业的素质和外部环境的状况以及所处的生命周期阶段来定位,确立其实际的内容.     

分次环的Brown-McCoy根

研究了分次环的Brown-McCoy根,用新的方法证明并推广了文献[1]中的主要结果,证明在比自由群更广泛的群类上分次环的Brown-McCoy根是分次的.     

舰船·天安门·顶戴花翎——“‘洋务运动‘博物馆“东立面形象反思

通过对“洋务运动博物馆”东立面形象的反思 ,讨论了建筑形态设计中隐喻手法的运用 ;就此引申 ,探讨传统问题 ,指出正确理解传统与创新的四个方面。