Nonsense suppression therapies in human genetic diseases

Cellular and Molecular Life Sciences - About 11% of all human disease-associated gene lesions are nonsense mutations, resulting in the introduction of an in-frame premature translation-termination...     

Activity patterns and habitat use of pudu deer (Pudu puda) in a mountain forest of south-central Chile

The pudu (Pudu puda) is a small, endemic deer, and the only native ungulate found in Chilean and Argentinean temperate forests. Its ecology, including its double role as an herbivore and as a prey, is poorly known. Therefore, it is pressing to gain a better understanding of the pudu given that its habitat is being transformed rapidly by anthropogenic causes. On a coastal mountain range in south-central Chile, we conducted a habitat use study and examined the activity patterns of the pudu using camera traps. The study area was a large native forest patch, surrounded by commercial plantations which would not constitute a habitat for this deer. Using a sampling effort of 7559 camera days, we found that this deer was largely nocturnal with little activity during daytime. The pudu selected Araucaria forests, and avoided Nothofagus forests. These behaviours suggest that the pudu traded off habitat use patterns and activity time to avoid predation, mainly by puma which is the top predator in the rich local community of carnivores occurring in the latter habitat.     

New distribution records for the Querétero dusky rattlesnake Crotalus aquilus (Viperidae), with comments on morphology and habitat use

We provide the 1st documented accounts of the Mexican endemic rattlesnake Crotalus aquilus from the state of México. The new records extend the known distribution of the species into a region where it may be sympatric with the superficially similar C. triseriatus . Because these taxa have previously been subject to some taxonomic confusion, we performed a preliminary morphological comparison using individuals of both species obtained from proximal localities. Our analyses support the supposition that these taxa are morphologically distinct. The new localities for C. aquilus are situated in high valleys that have been extensively modified by human settlement and agriculture.     

Nonparametric density forecast based on time‐ and state‐domain

We propose a new nonparametric density forecast based on time‐ and state‐domain smoothing. We analyze some of its asymptotic properties and provide an empirical illustration. Copyright © 2010 John Wiley & Sons, Ltd.