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671.
Tsjalling Swierstra 《Foundations of Science》2017,22(2):275-278
In this review I argue that Puech draws on two important currents in modern thought: the criticism of the ontological and social priority of conflict, and the rehabilitation of praxis vis-à-vis theoria. Still, his plea for a non-confrontational art of living leaves important questions unanswered. What is the problem exactly? What does exactly count as (non)confrontational? What is non-confrontation exactly meant to solve? What is the antiposition here? And: how does this new (or rather: old) art of living relate to the political and ethical varieties of Technology Assessment? 相似文献
672.
This paper considers the mixed covolume method for the second-order elliptic equations over quadrilaterals.Superconvergence results are established in this paper on quadrilateral grids satisfying the h~2-parallelogram condition when the lowest-order Raviart-Thomas space is employed in the mixed covolume method.The authors prove O(h~2) accuracy between the approximate velocity or pressure and a suitable projection of the real velocity or pressure in the L~2 norm.Numerical experiments illustrating the theoretical results are provided. 相似文献
673.
This paper studies a maximum likelihood estimator (MLE) of the parameter for a continuous one-parameter exponential family under ranked set sampling (RSS). The authors first find the optimal RSS according to the character of the family, viz, arrange the RSS based on quasi complete and sufficient statistic of independent and identically distributed (iid) samples. Then under this RSS, some sufficient conditions for the existence and uniqueness of the MLE, which are easily used in practice, are obtained. Using these conditions, the existence and uniqueness of the MLEs of the parameters for some usual distributions in this family are proved. Numerical simulations for these distributions fully support the result from the above two step optimizations of the sampling and the estimation method. 相似文献
674.
675.
Elena C. Gianulis Chantelle Labib Gintautas Saulis Vitalij Novickij Olga N. Pakhomova Andrei G. Pakhomov 《Cellular and molecular life sciences : CMLS》2017,74(9):1741-1754
Tumor ablation by nanosecond pulsed electric fields (nsPEF) is an emerging therapeutic modality. We compared nsPEF cytotoxicity for human cell lines of cancerous (IMR-32, Hep G2, HT-1080, and HPAF-II) and non-cancerous origin (BJ and MRC-5) under strictly controlled and identical conditions. Adherent cells were uniformly treated by 300-ns PEF (0–2000 pulses, 1.8 kV/cm, 50 Hz) on indium tin oxide-covered glass coverslips, using the same media and serum. Cell survival plotted against the number of pulses displayed three distinct regions (initial resistivity, logarithmic survival decline, and residual resistivity) for all tested cell types, but with differences in LD50 spanning as much as nearly 80-fold. The non-cancerous cells were less sensitive than IMR-32 neuroblastoma cells but more vulnerable than the other cancers tested. The cytotoxic efficiency showed no apparent correlation with cell or nuclear size, cell morphology, metabolism level, or the extent of membrane disruption by nsPEF. Increasing pulse duration to 9 µs (0.75 kV/cm, 5 Hz) produced a different selectivity pattern, suggesting that manipulation of PEF parameters can, at least for certain cancers, overcome their resistance to nsPEF ablation. Identifying mechanisms and cell markers of differential nsPEF susceptibility will critically contribute to the proper choice and outcome of nsPEF ablation therapies. 相似文献
676.
Aquaporins are implicated in a wide variety of plant physiological processes, although the mechanisms involved in their regulation are not fully understood. To gain further insight into the regulatory factors involved in this process, we used a yeast two-hybrid system to screen for potential binding partners to the Arabidopsis tonoplast intrinsic protein (TIP) AtTIP1;1. This was the first protein identified to be associated with high water permeability in vacuolar membranes from Arabidopsis thaliana. Using ... 相似文献
677.
Two letters from William Burnside have recently been found in the Nachlass of Robert Fricke that contain instances of the Burnside Problem prior to its first publication. We present these letters
as a whole to the public for the first time. We draw a picture of these two mathematicians and describe their activities leading
to their correspondence. We thus gain an insight into their respective motivations, reactions, and attitudes, which may sharpen
the current understanding of professional and social interactions of the mathematical community at the turn of the twentieth
century.
Dedicated to Heiko Harborth on the occasion of his seventieth birthday. 相似文献
678.
Sergio Porté Agrin Moeini Irene Reche Naeem Shafqat Udo Oppermann Jaume Farrés Xavier Parés 《Cellular and molecular life sciences : CMLS》2011,68(6):1065-1077
Human ζ-crystallin is a Zn2+-lacking medium-chain dehydrogenase/reductase (MDR) included in the quinone oxidoreductase (QOR) family because of its activity
with quinones. In the present work a novel enzymatic activity was characterized: the double bond α,β-hydrogenation of medium-chain
2-alkenals and 3-alkenones. The enzyme is especially active with lipid peroxidation products such as 4-hydroxyhexenal, and
a role in their detoxification is discussed. This specificity is novel in the QOR family, and it is similar to that described
in the distantly related alkenal/one reductase family. Moreover, we report the X-ray structure of ζ-crystallin, which represents
the first structure solved for a tetrameric Zn2+-lacking MDR, and which allowed the identification of the active-site lining residues. Docking simulations suggest a role
for Tyr53 and Tyr59 in catalysis. The kinetics of Tyr53Phe and Tyr59Phe mutants support the implication of Tyr53 in binding/catalysis
of alkenal/one substrates, while Tyr59 is involved in the recognition of 4-OH-alkenals. 相似文献
679.
The effects of Cl-concentration,temperature,pH,flow velocity,soluble oxygen content of seawater and anodic current on the potential of high purity zinc and Zn-Al-Cd reference electrodes were investigated. The results show that the investigated metal materials are liable to establish stable potential and act as reference electrodes in seawater,diluted seawater and urban tap water. Cl-concentration,temperature,seawater flow velocity and anodic current have an obvious effect on zinc potentials. However,seawate... 相似文献
680.
To better understand variation of Holocene Chinese mandiblular morphology, a study was conducted on 23 metric traits of Neolithic (n=54), Bronze-Iron Ages (n=184) and modern (n=92) adult male mandibles from northern China. Results indicate that the linear characters of these Chinese mandibles evolved in the past 7000 years. From the Neolithic to Bronze-Iron Ages to present day, the overall size of mandibles decreased. The linear characters of the mandiblular features varied between different time periods. The decrease of thickness and height of the mandibular corpus primarily occurred during the Neolithic to Bronze-Iron Ages. The decrease in main size was during the Bronze-Iron Ages to present day. It is possible that mandibles became thinner before the overall size decreased. Comparisons also indicate that the bottom part of the face may have decreased more greatly in breadth than the upper portion. The decrease in mandible size may be associated with changes in climate and diet, and with changes in the craniums size. 相似文献