The international electrical units: a failure in standardisation?

The ‘international’ electrical units, initially defined by the International Electrical Congress of Chicago in 1893, represented a major step forward in international electrical standardisation. Yet they were flawed both theoretically and technically, were adopted inconsistently in different countries and were soon subject to criticism and revision. This paper addresses the extent to which the international units—notwithstanding their flaws—were in fact adequate for the needs of engineering, commerce and science at the time, and concludes that the practical position was actually very satisfactory. It also addresses how the international electrical units came in to being, in the context of alternative philosophies of the nature of the standardisation process—that it can be essentially central or local. The central influence on the international units was the series of international electrical congresses of the late nineteenth century, which I conclude were a highly unsatisfactory mechanism, responsible for many of the weaknesses in the resulting standards. In contrast, I argue that it was local influences, the networks of scientists and standards laboratories that defined and maintained the standards, which gave them their strength.     

Time-series forecasting of the German unemployment rate

The purpose of the paper is to investigate the accuracy of forecasts derived from univariate and multivariate time-series models. An iterative method to adjust for impact assessment in univariate ARIMA models is discussed and illustrated for the German unemployment rate. Finally, we also examine the pros and cons of the impact assessment model in comparison with VAR models.     

非线性最优化及其在金融中的应用

本书是根据作者在Hertfordshire大学与Bergamo大学为本科生和研究生教授非线性优化方面的讲稿编撰而成的，中心内容是非线性最优化的数值方法。     

A common inversion under selection in Europeans

A refined physical map of chromosome 17q21.31 uncovered a 900-kb inversion polymorphism. Chromosomes with the inverted segment in different orientations represent two distinct lineages, H1 and H2, that have diverged for as much as 3 million years and show no evidence of having recombined. The H2 lineage is rare in Africans, almost absent in East Asians but found at a frequency of 20% in Europeans, in whom the haplotype structure is indicative of a history of positive selection. Here we show that the H2 lineage is undergoing positive selection in the Icelandic population, such that carrier females have more children and have higher recombination rates than noncarriers.     

Dysregulation of the TSC-mTOR pathway in human disease

The mammalian target of rapamycin (mTOR) has a central role in the regulation of cell growth. mTOR receives input from multiple signaling pathways, including growth factors and nutrients, to stimulate protein synthesis by phosphorylating key translation regulators such as ribosomal S6 kinase and eukaryote initiation factor 4E binding protein 1. High levels of dysregulated mTOR activity are associated with several hamartoma syndromes, including tuberous sclerosis complex, the PTEN-related hamartoma syndromes and Peutz-Jeghers syndrome. These disorders are all caused by mutations in tumor-suppressor genes that negatively regulate mTOR. Here we discuss the emerging evidence for a functional relationship between the mTOR signaling pathway and several genetic diseases, and we present evidence supporting a model in which dysregulation of mTOR may be a common molecular basis, not only for hamartoma syndromes, but also for other cellular hypertrophic disorders.