Hypocrellins, as a kind of novel phototherapeutic agents, have several advantages over the clinically used hematoporphyrin derivatives, including high-excited triplet state yield, high phototoxicity, low dark toxicity, and rapid metabolism. However, they exhibit little absorption in the photodynamic window (600--900 nm) and are not water soluble, which limits their application in photodynamic therapy. Sulfonated and metal-ioned hypocrellins have been designed and synthesized to improve their water solubility.Unfortunately, the water-soluble derivatives obtained exhibit lower photodynamic activity than the parent hypocrellins.Thiolated and aminated hypocrellins have also been designed and synthesized to enlarge their photoresponse. Among them,the aminated hypocrellins possess the highest photodynamic activity. We recently have further designed and synthesized some amphiphilic aminated hypocrellin derivatives. Thus,not only the photoresponse but also the water solubility is enhanced. The experiments in vitro and in vivo on the derivatives are under way at present. 相似文献
An angiosperm compression flora is found in Palaeogene from Lanzhou Basin and the cuticular analysis of Populus davidiana Dode in the flora is carefully made. Furthermore, the fossil cuticles are compared with the epidermal structures of extant Populus leaves growing in different environments, i.e. moist, semimoist, and semiarid to arid climatic regions. The present experiments indicate that mature leaves of P. davidiana show leaf size from big to small, leaf cuticles from thick to thin and anticlinal walls of epidermal cells from faintness to clarity along with the increase of lattudes of the plant distributions, the climatic variation from moist to arid, the annual precipitation from more to less and the annual mean temperature from high to low. The fossil P. davidiana differs from the specimens collected from Shandan in semiarid to arid climatic regions but closely resembles the Wushan leaves in a semi-moist climatic area in a lot of features. In a word, the new research may reflect that the flora lives in a semi-moist climatic environment. The present discovery of compression of Paleogene Populus davidiana is of great significance to studying vegetation types, climatic and environmental changes during the primal uplifting of the Qinghai-Tibet Plateau. 相似文献
Removal of NOx(DeNOx, NOx is the total of NO and NO2) from flue gas by radical injection has been investigated .the discharge characteristics were examined and the steady streamer corona was acquired hy adjusting the nozzle gases properly. It was Found that an increase in the voltage resulted in a decrease in the NO concentration and the concentration of the NO2 increased at tow voltages but decreased as the voltage rose to a certain level. The DeNOx efficiency increased as the applied voltage rose and reached a maximum of 70% when the voltage approached the breakdown voltage. The hypothetical mechanism of NOx removal suggested that the radicals formed in the discharge process converted the NO and NO2 into acidic species. The Monte Carlo method was used to calculate the rate coefficients and the productivity of the radicals, and then the concentrations of both NO and NO2 and the DeNOx effielencies were calculated with chemical kinetics. The calculated DeNOx efficiencies were coalparable with the experimental DeNOx efficiencies at low voltages, but were lower at high voltages. 相似文献
Understanding the doping mechanisms in the simplest superconducting copper oxide-the infinite-layer compound ACuO2 (where A is an alkaline earth metal)-is an excellent way of investigating the pairing mechanism in high-transition-temperature (high-Tc) superconductors more generally. Gate-induced modulation of the carrier concentration to obtain superconductivity is a powerful means of achieving such understanding: it minimizes the effects of potential scattering by impurities, and of structural modifications arising from chemical dopants. Here we report the transport properties of thin films of the infinite-layer compound CaCuO2 using field-effect doping. At high hole- and electron-doping levels, superconductivity is induced in the nominally insulating material. Maximum values of Tc of 89 K and 34 K are observed respectively for hole- and electron-type doping of around 0.15 charge carriers per CuO2. We can explore the whole doping diagram of the CuO2 plane while changing only a single electric parameter, the gate voltage. 相似文献
The 2 °C warming target has been used widely in global and regional climate change research. Previous studies have shown large uncertainties in the time when surface air temperature (SAT) change over China will reach 2 °C relative to the pre-industrial era. To understand the uncertainties, we analyzed the projected SAT in the twenty-first century using 40 state-of-the-art climate models under two Representative Concentration Pathways (RCP4.5 and RCP8.5) from the Coupled Model Intercomparison Project Phase 5. The 2 °C threshold-crossing time (TCT) of SAT averaged across China was around 2033 and 2029 for RCP4.5 and RCP8.5, respectively. Considering a ±1σ range of intermodel SAT change, the upper and lower bounds of the 2 °C TCT could differ by about 25 years or even more. Uncertainty in the projected SAT and the warming rate around the TCT are the two main factors responsible for the TCT uncertainty. The former is determined by the climate sensitivity represented by the global mean surface temperature response. About 45 % of the intermodel variance of the projected 2 °C TCT for averaged SAT over China can be explained by climate sensitivity across the models, which is contributed mainly by central and southern China. In a climate more sensitive to CO2 forcing, stronger greenhouse effect, less stratus cloud over the East Asian monsoon region, and less snow cover on the Tibetan Plateau result in increased downward longwave radiation, increased shortwave radiation, and decreased shortwave radiation reflected by the surface, respectively, all of which may advance the TCT. 相似文献
The scale-free and small-world properties are studied in detail for the complex earthquake networks constructed from the seismic data sets taken from California (USA), Japan, Iran and Chile. It is found that, in all these geographical regions, both the exponent / of the power-law connectivity distribution and the clustering coefficient C take the universal invariant values /≈1 and C≈0.85, respectively, as the cell size, which is the scale of coarse graining needed for construction of network, becomes larger than a certain value. A possible physical interpretation is given to the emergence of such remarkable invariance. 相似文献
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate digestive processes and gastrointestinal homeostasis. Because ENS components are in charge of the autonomous regulation of gut function, it is inevitable that their dysfunction is central to the pathophysiology and symptom generation of gastrointestinal disease. While for neurodevelopmental disorders such as Hirschsprung, ENS pathogenesis appears to be clear-cut, the role for impaired ENS activity in the etiology of other gastrointestinal disorders is less established and is often deemed secondary to other insults like intestinal inflammation. However, mounting experimental evidence in recent years indicates that gastrointestinal homeostasis hinges on multifaceted connections between the ENS, and other cellular networks such as the intestinal epithelium, the immune system, and the intestinal microbiome. Derangement of these interactions could underlie gastrointestinal disease onset and elicit variable degrees of abnormal gut function, pinpointing, perhaps unexpectedly, the ENS as a diligent participant in idiopathic but also in inflammatory and cancerous diseases of the gut. In this review, we discuss the latest evidence on the role of the ENS in the pathogenesis of enteric neuropathies, disorders of gut–brain interaction, inflammatory bowel diseases, and colorectal cancer.