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121.
Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification 总被引:8,自引:0,他引:8
Rutsch F Ruf N Vaingankar S Toliat MR Suk A Höhne W Schauer G Lehmann M Roscioli T Schnabel D Epplen JT Knisely A Superti-Furga A McGill J Filippone M Sinaiko AR Vallance H Hinrichs B Smith W Ferre M Terkeltaub R Nürnberg P 《Nature genetics》2003,34(4):379-381
Idiopathic infantile arterial calcification (IIAC; OMIM 208000) is characterized by calcification of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation. We analyzed affected individuals from 11 unrelated kindreds and found that IIAC was associated with mutations that inactivated ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1). This cell surface enzyme generates inorganic pyrophosphate (PP(i)), a solute that regulates cell differentiation and serves as an essential physiologic inhibitor of calcification. 相似文献
122.
Paramyosin and actin in schistosomal teguments 总被引:24,自引:0,他引:24
Schistosomes are blood-dwelling trematode parasites that infect 200 million people in developing countries. The critical role served by the tegument in immune evasion and parasite homeostasis suggests that a detailed knowledge of tegumental components would be helpful in the design of new drugs and the production of vaccines. We demonstrate here, by immunoelectron microscopy, that the cytoskeletal proteins actin and paramyosin are organized into major tegumental structures of Schistosoma mansoni. The surface spines are composed of paracrystalline arrays of actin filaments. Actin is also present in areas recovering from damage, implying an important role for this structural protein in tegumental repair. Paramyosin exists predominantly in the tegument in a non-filamentous form, the membrane-bounded elongate bodies. The localization of this protein to the tegument of the parasite is the likely basis for resistance to S. mansoni observed in mice immunized with paramyosin (refs 1, 2 and T. P. Flanigen et al., in preparation). 相似文献
123.
由湿法叠涂制得的聚丙烯腈(PA N )/酚醛基碳/碳(C/C )复合材料在高性能结构材料领域具有应用潜力.为了了解炭化步骤对聚丙烯腈/酚醛基碳/碳复合材料结构和力学性能的影响 ,进行了层间断裂韧性(模式Ⅱ)测试.由于结构特征与裂纹形成机理的相互关系对C/C-SiC复合材料的制备很重要 ,采用阿基米德方法、扫描电子显微镜(SEM )和三点弯曲试验对复合材料的结构进行表征.实验结果显示 ,碳/碳(C/C)试件的层间断裂韧性为碳纤维增强酚醛塑料(CFRP)试件的59.7%. 相似文献
124.
The effects of aging temperature and time on the hardness and impact toughness of a copper-bearing high-strength low-carbon steel were investigated. The hardness of the aged samples reached maxima after 1 h and 5 h of aging at 500 and 450℃, respectively; this increase in hardness was followed by a decrease in hardness until a temperature of 700℃, at which secondary hardening was observed. The impact toughness of the aged steel was found to be higher for 5 h of aging. Transmission electron microscopy confirmed the presence of carbide and copper precipitates; also, the secondary hardening could be the result of the transformation of austenite (formed in the aging treatment) to martensite. Differential scanning calorimetry of the steel was performed to better understand the precipitation behavior. The results revealed that the precipitation of the steel exhibited two significant stages of copper precipitate nucleation and coarsening of the precipitates, with corresponding activation energies of 49 and 238 kJ·mol-1, respectively. 相似文献
125.
According to Vening Meinesz-Moritz (VMM) global inverse isostatic problem, either the Moho density contrast (crust-mantle density contrast) or the Moho geometry can be estimated by solv-ing a non-linea... 相似文献